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Methyl difluoroacetate

CAS No.
433-53-4
Chemical Name:
Methyl difluoroacetate
Synonyms
AKOS B020262;ART-CHEM-BB B020262;Methyl difluoroacetate;MethylDifluoroacetate>methyl2,2-difluoroacetate;Methyldifluoroacetate,99%;Methyl difluoroacetate 99%;DIFLUOROACETIC ACID METHYL ESTER;ethanoicacid,difluoro-,methylester;α,2-Difluoroacetic acid methyl ester
CBNumber:
CB2680653
Molecular Formula:
C3H4F2O2
Molecular Weight:
110.06
MDL Number:
MFCD00039276
MOL File:
433-53-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:23

Methyl difluoroacetate Properties

Boiling point 85-86 °C (lit.)
Density 1.26 g/mL at 25 °C (lit.)
refractive index n20/D 1.334(lit.)
Flash point 75 °F
form clear liquid
Specific Gravity 1.272
color Colorless to Almost colorless
Water Solubility Slightly soluble in water.
BRN 1747534
InChI InChI=1S/C3H4F2O2/c1-7-3(6)2(4)5/h2H,1H3
InChIKey CSSYKHYGURSRAZ-UHFFFAOYSA-N
SMILES C(OC)(=O)C(F)F
CAS DataBase Reference 433-53-4(CAS DataBase Reference)
FDA UNII 6U74LQW4K6
EPA Substance Registry System Methyl 2,2-difluoroacetate (433-53-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H302+H312+H332-H315-H319-H335
Precautionary statements  P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,F
Risk Statements  10-20/21/22-36/37/38
Safety Statements  16-23-36/37/39
RIDADR  UN 1993 3/PG 3
WGK Germany  3
Hazard Note  Flammable
HazardClass  3
PackingGroup  II
HS Code  29159000
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
3
3 0

Methyl difluoroacetate price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 295914 Methyl difluoroacetate 96% 433-53-4 5g $34.3 2026-04-30 Buy
Sigma-Aldrich 295914 Methyl difluoroacetate 96% 433-53-4 25g $110 2026-04-30 Buy
TCI Chemical M2021 Methyl Difluoroacetate >97.0%(GC) 433-53-4 5g $37 2026-04-30 Buy
TCI Chemical M2021 Methyl Difluoroacetate >97.0%(GC) 433-53-4 25g $114 2026-04-30 Buy
Usbiological 284797 Methyl Difluoroacetate Asreported 433-53-4 5g $312 2026-06-03 Buy
Product number Packaging Price Buy
295914 5g $34.3 Buy
295914 25g $110 Buy
M2021 5g $37 Buy
M2021 25g $114 Buy
284797 5g $312 Buy

Methyl difluoroacetate Chemical Properties, Uses, Production

Chemical Properties

Colorless liquid

Uses

A methyl difluoroacetate (MFA)-based LiPF6 solution was applied as an electrolyte to improve the thermal stability of Li-ion batteries. Methyl difluoroacetate is used in the inhibition of corrosion of aluminum cathode current collector for lithium ion cells.

General Description

The gas-phase reactions of Cl atoms with methyl difluoroacetate have been investigated at 296 ± 2K and atmospheric pressure of synthetic air.

Methyl difluoroacetate Preparation Products And Raw materials

Global Suppliers ( 194)
Supplier Tel Email Country ProdList Advantage
Shangfluoro 021-65170832 15601903708 qinba_2@163.com China 318 58
Xinlian Rui Biomedical Technology (Shandong) Co., Ltd 0531-84567878 15153173989 3865799121@qq.com China 79 58
jinanzhonglanhuagongyouxiangongsi 15169176553; 15169176553 644658103@qq.com China 32 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64

View Latest Price from Methyl difluoroacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
METHYL DIFLUOROACETATE pictures 2026-08-25 METHYL DIFLUOROACETATE
433-53-4
$50.00-500.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
METHYL DIFLUOROACETATE pictures 2019-07-06 METHYL DIFLUOROACETATE
433-53-4
$7.00 1kg 99% 100kg Career Henan Chemical Co
Difluoroacetic acid methyl ester, Methyl 2,2-difluoroethanoate ART-CHEM-BB B020262 DIFLUOROACETIC ACID METHYL ESTER AKOS B020262 Acetic acid, difluoro-, methyl ester ethanoicacid,difluoro-,methylester Methyldifluoroacetate,99% methyl2,2-difluoroacetate α,2-Difluoroacetic acid methyl ester Methyl difluoroacetate 99% MethylDifluoroacetate> Acetic acid, 2,2-difluoro-, methyl ester Methyl difluoroacetate 433-53-4 433-53-6 C3H4F2O2 F2CHCO2CH3 Carbonyl Compounds C2 to C5 Building Blocks Esters Organic Building Blocks Pyridines C2 to C5 Carbonyl Compounds Esters Building Blocks C2 to C5 Carbonyl Compounds Chemical Synthesis Difluoromethyl Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks