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1-Bromo-2,5-difluorobenzene

1-Bromo-2,5-difluorobenzene Structure
1-Bromo-2,5-difluorobenzene structure
CAS No.
399-94-0
Chemical Name:
1-Bromo-2,5-difluorobenzene
Synonyms
2-BROMO-1,4-DIFLUOROBENZENE;NSC 10250;2-Bromo-1,4-difL;1-Bromo-2,5-difluoro;2,5-DIFLUOROBROMOBENZENE;2-Brom-1,4-difluorbenzol;1,4-Difluoro-2-bromobenzene;1-BROMO-2,5-DIFLUOROBENZENE;2,5-Difluorobromobenzene 98%;1-Bromo-2,5-difluorobenzene98%
CBNumber:
CB2701983
Molecular Formula:
C6H3BrF2
Molecular Weight:
192.99
MDL Number:
MFCD00000345
MOL File:
399-94-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:43:07
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1-Bromo-2,5-difluorobenzene Properties

Melting point −31 °C(lit.)
Boiling point 58-59 °C20 mm Hg(lit.)
Density 1.708 g/mL at 25 °C(lit.)
refractive index n20/D 1.508(lit.)
Flash point 149 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light yellow to Light orange
Specific Gravity 1.708
Water Solubility Insoluble
BRN 1680893
InChI InChI=1S/C6H3BrF2/c7-5-3-4(8)1-2-6(5)9/h1-3H
InChIKey XCRCSPKQEDMVBO-UHFFFAOYSA-N
SMILES C1(F)=CC=C(F)C=C1Br
CAS DataBase Reference 399-94-0(CAS DataBase Reference)
FDA UNII U82UU94PVP
NIST Chemistry Reference Benzene, 2-bromo-1,4-difluoro-(399-94-0)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,F,Xn
Risk Statements  36/37/38
Safety Statements  26-36/37/39-2637/39-37/39
RIDADR  UN 2922
WGK Germany  3
Hazard Note  Flammable
HazardClass  IRRITANT, FLAMMABLE
HS Code  29039990
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

1-Bromo-2,5-difluorobenzene price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 247952 2-Bromo-1,4-difluorobenzene 98% 399-94-0 5g $45.1 2023-06-20 Buy
TCI Chemical B1166 1-Bromo-2,5-difluorobenzene >98.0%(GC) 399-94-0 5g $32 2026-04-30 Buy
TCI Chemical B1166 1-Bromo-2,5-difluorobenzene >98.0%(GC) 399-94-0 25g $58 2026-04-30 Buy
Strem Chemicals 09-0032 1-Bromo-2,5-difluorobenzene, min. 98% min.98% 399-94-0 25g $36 2026-04-30 Buy
Strem Chemicals 09-0032 1-Bromo-2,5-difluorobenzene, min. 98% min.98% 399-94-0 100g $95 2026-04-30 Buy
Product number Packaging Price Buy
247952 5g $45.1 Buy
B1166 5g $32 Buy
B1166 25g $58 Buy
09-0032 25g $36 Buy
09-0032 100g $95 Buy

1-Bromo-2,5-difluorobenzene Chemical Properties, Uses, Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2-Bromo-1,4-difluorobenzene has been used in the preparation of 1,4-difluoroanthraquinone, a precursor to ametantrone.

General Description

Lithiation of 2-bromo-1,4-difluorobenzene in the presence of lithium diisopropylamide (LDA) in THF-hexane, butyllithium in diethyl ether-hexane and butyllithium in THF-hexane has been reported.

Synthesis

Bromobenzene

108-86-1

2-Bromofluorobenzene

1072-85-1

1-Bromo-2,5-difluorobenzene

399-94-0

3-Bromofluorobenzene

1073-06-9

4-Bromo-1,2-difluorobenzene

348-61-8

4-Bromofluorobenzene

460-00-4

GENERAL STEPS: In a FEP or PFA reactor equipped with a PTFE-lined magnetic stir bar and connected to a gas scrubber bottle, substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (2 mL per mL of C6H5R), and BF3-Et2O (1.3-1.5 mmol/mmol C6H5R) were added. The mixture was stirred at 0-5 °C (ice bath) for 10-15 min, followed by batchwise addition of XeF2 (1.2-1.3 mmol/mmol C6H5R). After each addition, the mixture was stirred at 22-25 °C for 3-5 min and cooled to 0-5 °C again. After the addition was completed, the dark-colored solution was continued to be stirred at 22-25 °C for 15-30 min. Upon completion of the reaction, the reaction was quenched by the addition of 10% aqueous KHCO3, the upper organic layer was separated and filtered through a short column packed with silica gel (40-60 μm) and finally dried with magnesium sulfate. The solution was analyzed by 19F NMR and GC/MS. The major products are listed in the table and the others are as follows (GC/MS data provided).

References

[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8

1-Bromo-2,5-difluorobenzene synthesis

540-36-3
399-94-0
Synthesis of 1-Bromo-2,5-difluorobenzene from 1,4-Difluorobenzene

1-Bromo-2,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Bromobenzene

Preparation Products

2,5-Difluorobenzoic acid (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine 1,4-Difluoroanthraquinone 2,5-Difluoro-4-nitrobenzoic acid Larotrectinib Sulfate
4'-BroMo-2',5'-difluoroacetophenone Ethyl 2,5-difluorobenzoylformate

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1-Bromo-2,5-difluorobenzene Suppliers

Global Suppliers ( 476)
Supplier Tel Email Country ProdList Advantage
Fuxin Yinghui High tech Materials Technology Co., Ltd 17624188899 3799130626@qq.com China 199 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
Weifang Siyuan Chemical Co., Ltd. 0536-8888106 17663601818 2354379876@qq.com China 244 58
TAIZHOU DKD CHEMICAL CO., LTD. 0576-58336633 18658336633 yf.chen@tzdkdchem.com China 117 58
Zhejiang Xieshi New Materials Co., Ltd., 17858121723 sales09@xieshichem.com China 191 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Fuxin Yinghui High tech Materials Technology Co., Ltd 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Weifang Siyuan Chemical Co., Ltd. 58
TAIZHOU DKD CHEMICAL CO., LTD. 58
Zhejiang Xieshi New Materials Co., Ltd., 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81

View Latest Price from 1-Bromo-2,5-difluorobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Bromo-2,5-difluorobenzene pictures 2026-09-11 1-Bromo-2,5-difluorobenzene
399-94-0
 25KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
1-Bromo-2,5-difluorobenzene pictures 2026-09-02 1-Bromo-2,5-difluorobenzene
399-94-0
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
1-Bromo-2,5-difluorobenzene pictures 2025-06-27 1-Bromo-2,5-difluorobenzene
399-94-0
 $10.00-30.00 50KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd

1-Bromo-2,5-difluorobenzene Spectrum

1-Bromo-2,5-difluorobenzene(399-94-0)1HNMR1-Bromo-2,5-difluorobenzene(399-94-0)IR

399-94-0 (1-Bromo-2,5-difluorobenzene) Related Search:

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1,4-Difluoro-2-bromobenzene 2,5-DIFLUOROBROMOBENZENE 1-BROMO-2,5-DIFLUOROBENZENE 1-Bromo-2,5-difluorobenzene 98% 1-Bromo-2,5-difluorobenzene98% 1-BROMO-2,5-DIFLUOROBENZENE 99.5% 1-Bromo-2,5-difluoro 2,5-Difluorobromobenzene 98% 2-Bromo-1,4-difluorobenzene 98% NSC 10250 2-Bromo-1,4-difL 1-Bromo-2,5-difluorobenzene > 2-Brom-1,4-difluorbenzol Benzene, 2-bromo-1,4-difluoro- 1-Bromo-2,5-difluorobenzene ISO 9001：2015 REACH 2-Bromo-1,4-difluorobenzene, 98%min 2-BROMO-1,4-DIFLUOROBENZENE 2,5-Difluorobromobenzene (1-Bromo-2,5-difluorobenzene) 399-94-0 Halogenated Hydrocarbons ARYL HALIDE Aryl Building Blocks Organic Building Blocks C6 Aryl Halogenated Hydrocarbons alkyl bromide| alkyl Fluorine Aromatic Hydrocarbons (substituted) & Derivatives Fluorobenzene Miscellaneous Bromine Compounds Fluorine Compounds Fluorobenzene Series bc0001 C6