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1-Bromo-2,5-difluorobenzene

1-Bromo-2,5-difluorobenzene structure

CAS No.: 399-94-0

Chemical Name:: 1-Bromo-2,5-difluorobenzene

Synonyms: 2-BROMO-1,4-DIFLUOROBENZENE;NSC 10250;2-Bromo-1,4-difL;1-Bromo-2,5-difluoro;2,5-DIFLUOROBROMOBENZENE;2-Brom-1,4-difluorbenzol;1,4-Difluoro-2-bromobenzene;1-BROMO-2,5-DIFLUOROBENZENE;2,5-Difluorobromobenzene 98%;1-Bromo-2,5-difluorobenzene98%

CBNumber:: CB2701983

Molecular Formula:: C6H3BrF2

Molecular Weight:: 192.99

MDL Number:: MFCD00000345

MOL File:: 399-94-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:16:48

Product description	Number	Pack Size	Price
2-Bromo-1,4-difluorobenzene 98%	247952	5g	$45.1
1-Bromo-2,5-difluorobenzene >98.0%(GC)	B1166	5g	$37
1-Bromo-2,5-difluorobenzene >98.0%(GC)	B1166	25g	$68
2-Bromo-1,4-difluorobenzene	B689648	2.5g	$65
2,5-Difluorobromobenzene	J51055	500g	$180
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1-Bromo-2,5-difluorobenzene Properties

Melting point	−31 °C(lit.)
Boiling point	58-59 °C20 mm Hg(lit.)
Density	1.708 g/mL at 25 °C(lit.)
refractive index	n20/D 1.508(lit.)
Flash point	149 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	Colorless to Light yellow to Light orange
Specific Gravity	1.708
Water Solubility	Insoluble
BRN	1680893
InChI	InChI=1S/C6H3BrF2/c7-5-3-4(8)1-2-6(5)9/h1-3H
InChIKey	XCRCSPKQEDMVBO-UHFFFAOYSA-N
SMILES	C1(F)=CC=C(F)C=C1Br
CAS DataBase Reference	399-94-0(CAS DataBase Reference)
FDA UNII	U82UU94PVP
NIST Chemistry Reference	Benzene, 2-bromo-1,4-difluoro-(399-94-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,F,Xn

Risk Statements

36/37/38

Safety Statements

26-36/37/39-2637/39-37/39

RIDADR

UN 2922

WGK Germany

Hazard Note

Flammable

HazardClass

IRRITANT, FLAMMABLE

HS Code

29039990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

1-Bromo-2,5-difluorobenzene price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	247952	2-Bromo-1,4-difluorobenzene 98%	399-94-0	5g	$45.1	2023-06-20	Buy
TCI Chemical	B1166	1-Bromo-2,5-difluorobenzene >98.0%(GC)	399-94-0	5g	$37	2025-07-31	Buy
TCI Chemical	B1166	1-Bromo-2,5-difluorobenzene >98.0%(GC)	399-94-0	25g	$68	2025-07-31	Buy
TRC	B689648	2-Bromo-1,4-difluorobenzene	399-94-0	2.5g	$65	2021-12-16	Buy
AK Scientific	J51055	2,5-Difluorobromobenzene	399-94-0	500g	$180	2021-12-16	Buy

Product number	Packaging	Price	Buy
247952	5g	$45.1	Buy
B1166	5g	$37	Buy
B1166	25g	$68	Buy
B689648	2.5g	$65	Buy
J51055	500g	$180	Buy

1-Bromo-2,5-difluorobenzene Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2-Bromo-1,4-difluorobenzene has been used in the preparation of 1,4-difluoroanthraquinone, a precursor to ametantrone.

General Description

Lithiation of 2-bromo-1,4-difluorobenzene in the presence of lithium diisopropylamide (LDA) in THF-hexane, butyllithium in diethyl ether-hexane and butyllithium in THF-hexane has been reported.

Synthesis

108-86-1

1072-85-1

399-94-0

1073-06-9

348-61-8

460-00-4

GENERAL STEPS: In a FEP or PFA reactor equipped with a PTFE-lined magnetic stir bar and connected to a gas scrubber bottle, substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (2 mL per mL of C6H5R), and BF3-Et2O (1.3-1.5 mmol/mmol C6H5R) were added. The mixture was stirred at 0-5 °C (ice bath) for 10-15 min, followed by batchwise addition of XeF2 (1.2-1.3 mmol/mmol C6H5R). After each addition, the mixture was stirred at 22-25 °C for 3-5 min and cooled to 0-5 °C again. After the addition was completed, the dark-colored solution was continued to be stirred at 22-25 °C for 15-30 min. Upon completion of the reaction, the reaction was quenched by the addition of 10% aqueous KHCO3, the upper organic layer was separated and filtered through a short column packed with silica gel (40-60 μm) and finally dried with magnesium sulfate. The solution was analyzed by 19F NMR and GC/MS. The major products are listed in the table and the others are as follows (GC/MS data provided).

References

[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8

1-Bromo-2,5-difluorobenzene synthesis

Synthesis of 1-Bromo-2,5-difluorobenzene from 1,4-Difluorobenzene

1-Bromo-2,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Bromobenzene

Preparation Products

2,5-Difluorobenzoic acid (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine 1,4-DIFLUOROANTHRAQUINONE 2,5-Difluoro-4-nitrobenzoic acid Larotrectinib Sulfate

4'-BroMo-2',5'-difluoroacetophenone Ethyl 2,5-difluorobenzoylformate

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1-Bromo-2,5-difluorobenzene Suppliers

Global( 462)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TAIZHOU DKD CHEMICAL CO., LTD.	+8618658336633	yf.chen@tzdkdchem.com	China	134	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19632	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	286	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20128	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58

Supplier	Advantage
TAIZHOU DKD CHEMICAL CO., LTD.	58
Aceschem Inc.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Anhui Zhongda Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
career henan chemical co	58

View Lastest Price from 1-Bromo-2,5-difluorobenzene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-13	1-Bromo-2,5-difluorobenzene 399-94-0	US $0.00 / KG	25KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-09-25	1-Bromo-2,5-difluorobenzene 399-94-0	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-06-27	1-Bromo-2,5-difluorobenzene 399-94-0	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

1-Bromo-2,5-difluorobenzene
399-94-0
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1-Bromo-2,5-difluorobenzene
399-94-0
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

1-Bromo-2,5-difluorobenzene
399-94-0
US $30.00-10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-Bromo-2,5-difluorobenzene Spectrum

1-Bromo-2,5-difluorobenzene(399-94-0)¹HNMR 1-Bromo-2,5-difluorobenzene(399-94-0)IR

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1,4-Difluoro-2-bromobenzene 2,5-DIFLUOROBROMOBENZENE 2-BROMO-1,4-DIFLUOROBENZENE 1-BROMO-2,5-DIFLUOROBENZENE 1-Bromo-2,5-difluorobenzene 98% 1-Bromo-2,5-difluorobenzene98% 1-BROMO-2,5-DIFLUOROBENZENE 99.5% 1-Bromo-2,5-difluoro 2,5-Difluorobromobenzene 98% 2-Bromo-1,4-difluorobenzene 98% NSC 10250 2-Bromo-1,4-difL 1-Bromo-2,5-difluorobenzene > 2-Brom-1,4-difluorbenzol Benzene, 2-bromo-1,4-difluoro- 1-Bromo-2,5-difluorobenzene ISO 9001：2015 REACH 2-Bromo-1,4-difluorobenzene, 98%min 399-94-0 Halogenated Hydrocarbons ARYL HALIDE Aryl Building Blocks Organic Building Blocks C6 Aryl Halogenated Hydrocarbons alkyl bromide| alkyl Fluorine Aromatic Hydrocarbons (substituted) & Derivatives Fluorobenzene Miscellaneous Bromine Compounds Fluorine Compounds Fluorobenzene Series bc0001 C6