3-Amino-1-propanesulfonic acid
- CAS No.
- 3687-18-1
- Chemical Name:
- 3-Amino-1-propanesulfonic acid
- Synonyms
- HOMOTAURINE;TRAMIPROSATE;3-AMINOPROPANE-1-SULFONIC ACID;3-AMINOPROPANESULFONIC ACID;3 APS;NC 758;TRAMIP;Alzhemed;NSC 77071;Homotaurin
- CBNumber:
- CB2741107
- Molecular Formula:
- C3H9NO3S
- Molecular Weight:
- 139.17
- MDL Number:
- MFCD00008225
- MOL File:
- 3687-18-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 293 °C (dec.)(lit.) |
|---|---|
| Density | 1.202 (estimate) |
| refractive index | 1.5130 (estimate) |
| storage temp. | 2-8°C |
| solubility | Water (Slightly) |
| pka | 1.06±0.50(Predicted) |
| form | Crystalline Powder |
| color | White to slightly blue |
| Cosmetics Ingredients Functions |
SURFACTANT - HYDROTROPE SURFACTANT - CLEANSING |
| InChI | InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7) |
| InChIKey | SNKZJIOFVMKAOJ-UHFFFAOYSA-N |
| SMILES | C(S(O)(=O)=O)CCN |
| LogP | -4.555 |
| CAS DataBase Reference | 3687-18-1(CAS DataBase Reference) |
| FDA UNII | 5K8EAX0G53 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN2585 | |||||||||
| WGK Germany | 1 | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Amino-1-propanesulfonic acid price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000116 | Acamprosate impurity A European Pharmacopoeia (EP) Reference Standard | 3687-18-1 | 110 mg | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | A76109 | 3-Amino-1-propanesulfonic acid 97% | 3687-18-1 | 1g | $52.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2822 | Acamprosate Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 3687-18-1 | 50MG | $341 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1000565 | Acamprosate Related Compound A United States Pharmacopeia (USP) Reference Standard | 3687-18-1 | 15mg | $1210 | 2026-04-30 | Buy |
| TCI Chemical | A2602 | 3-Amino-1-propanesulfonic Acid >98.0%(T) | 3687-18-1 | 5g | $127 | 2026-04-30 | Buy |
3-Amino-1-propanesulfonic acid Chemical Properties, Uses, Production
Description
Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.
Chemical Properties
White Powder
Uses
3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.
Definition
ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.
Biological Activity
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ISMAEL SANTA-MARIA. Tramiprosate, a drug of potential interest for the treatment of Alzheimer’s disease, promotes an abnormal aggregation of tau.[J]. Molecular Neurodegeneration, 2007: 17. DOI: 10.1186/1750-1326-2-17
[3] A. GIOTTI. Homotaurine: a GABAB antagonist in guinea-pig ileum[J]. British Journal of Pharmacology, 1983, 79 4: 855-862. DOI: 10.1111/j.1476-5381.1983.tb10529.x
3-Amino-1-propanesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Daolan Biomedical Technology Co., Ltd. | 13771737464 | sales@dolanchem.com | China | 2172 | 58 |
| Shanghai Eyougene Biotechnology Development Co.,Ltd. | 13564545227 | sales@eyougene.com | China | 165 | 58 |
| Hubei YoungXin Pharmaceutical Tech Co.,Ltd. | 0714-3999001 19171453112 | 2881391661@qq.com | China | 10000 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
View Latest Price from 3-Amino-1-propanesulfonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Amino-1-propanesulfonic acid
3687-18-1
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 3-Amino-1-propanesulfonic acid
3687-18-1
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-08-08 | Homotaurine
3687-18-1
|
10kg | 99.0%min | 3mt | Hangzhou ICH Biofarm Co., Ltd |
-
- 3-Amino-1-propanesulfonic acid
3687-18-1
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Amino-1-propanesulfonic acid
3687-18-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Homotaurine
3687-18-1
- $0.00
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
