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2-Methoxythiophene

2-Methoxythiophene Structure
2-Methoxythiophene structure
CAS No.
16839-97-7
Chemical Name:
2-Methoxythiophene
Synonyms
Methoxythiophene;2-METHOXYTHIOPHENE;Thiophene, 2-methoxy-;2-Methoxythiophene>2-Methoxythiophene 97%;2-Methoxythiophene,99%;2-Methoxythiophene,97%;METHYL 2-THIENYL ETHER;2-Methoxythiophene ISO 9001：2015 REACH
CBNumber:
CB2748272
Molecular Formula:
C5H6OS
Molecular Weight:
114.17
MDL Number:
MFCD00014526
MOL File:
16839-97-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:44:23
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2-Methoxythiophene Properties

Boiling point 151-152 °C/762 mmHg (lit.)
Density 1.133 g/mL at 25 °C (lit.)
refractive index n20/D 1.528(lit.)
Flash point 110 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol (Slightly)
form clear liquid
color Colorless to Light yellow to Light orange
BRN 106271
InChI InChI=1S/C5H6OS/c1-6-5-3-2-4-7-5/h2-4H,1H3
InChIKey OKEHURCMYKPVFW-UHFFFAOYSA-N
SMILES C1(OC)SC=CC=1
LogP 2.130
CAS DataBase Reference 16839-97-7(CAS DataBase Reference)
NIST Chemistry Reference 2-Methoxythiophene(16839-97-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)
GHS02
Signal word  Warning
Hazard statements  H226
Precautionary statements  P210-P240-P241-P280a-P303+P361+P353-P501a
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Risk Statements  10
Safety Statements  16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
HazardClass  3
PackingGroup  III
HS Code  29349990
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
0 0

2-Methoxythiophene price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 331597 2-Methoxythiophene 97% 16839-97-7 5g $134 2026-04-30 Buy
TCI Chemical M1030 2-Methoxythiophene >98.0%(GC) 16839-97-7 5g $78 2026-04-30 Buy
TCI Chemical M1030 2-Methoxythiophene >98.0%(GC) 16839-97-7 25g $264 2026-04-30 Buy
Apolloscientific OR937091 2-Methoxythiophene >98% 16839-97-7 5g $21 2026-06-04 Buy
Apolloscientific OR937091 2-Methoxythiophene >98% 16839-97-7 25g $41 2026-06-04 Buy
Product number Packaging Price Buy
331597 5g $134 Buy
M1030 5g $78 Buy
M1030 25g $264 Buy
OR937091 5g $21 Buy
OR937091 25g $41 Buy

2-Methoxythiophene Chemical Properties, Uses, Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

2-Methoxythiophene was used in thermal reaction (60°C) of (C5Me5)Rh(PMe3)(Ph)H.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 3697, 1953 DOI: 10.1021/ja01111a027

General Description

2-Methoxythiophene is a heterocyclic methyl enol ether and its reaction with o-quinone monoimide was studied. The intramolecular and intermolecular geometries of crystals of 2-methoxythiophene were investigated. Kinetics of the hydronium-ion catalysed hydrolysis of 2-methoxythiophene was reported.

Synthesis

2-Bromothiophene

1003-09-4

Sodium Methoxide

124-41-4

2-Methoxythiophene

16839-97-7

Example 1 Preparation of 2-methoxythiophene: In a reactor, 300 g of 2-bromothiophene (1.84 mol), 2.64 g of copper(I) bromide (CuBr, 1 mol%), 18.4 g of polyethylene glycol dimethyl ether (PEG DME 500, 2 mol%), and 660 g of a methanolic solution of sodium methanolate (30% concentration, precursor concentration of 30.6%) were added in sequence. The mixture was heated to 90 °C for the reaction and the progress of the reaction was monitored by gas chromatography (GC) until the conversion was >98% (total reaction time 8h). Upon completion of the reaction, the reaction mixture was slowly poured into 500 g of water and filtered through Decalite. Subsequently, the aqueous phase was extracted twice with methyl tert-butyl ether (MTBE, 150 g each time). The organic phases were combined and purified by vacuum fractional distillation to give a final 182 g of 2-methoxythiophene (1.59 mol, 86.4% yield) with a GC purity of >99% (% area).

References

[1] Patent: US2008/71084, 2008, A1. Location in patent: Page/Page column 3-4
[2] Synthetic Communications, 1990, vol. 20, # 2, p. 213 - 216
[3] Tetrahedron, 1992, vol. 48, # 17, p. 3633 - 3652
[4] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8651 - 8664

2-Methoxythiophene Preparation Products And Raw materials

Raw materials

2-Bromothiophene 2-Iodothiophene Methanol Sodium Methoxide

Preparation Products

3-Iodothiophene

2-Methoxythiophene Suppliers

Global Suppliers ( 240)
Supplier Tel Email Country ProdList Advantage
Entrenture (Lanzhou) Biomedical Technology Co., Ltd 18119421752 13919408782 1297709337@qq.com China 472 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Puyang Huicheng Electronic Material Co. Ltd. 0393-0393-8910800 15039333257 info@huichengchem.com China 588 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Supplier Advantage
Entrenture (Lanzhou) Biomedical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
future industrial shanghai co., ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Tetranov Biopharm 64
Puyang Huicheng Electronic Material Co. Ltd. 64
Accela ChemBio Co.,Ltd. 64

View Latest Price from 2-Methoxythiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methoxythiophene pictures 2026-09-02 2-Methoxythiophene
16839-97-7
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
2-Methoxythiophene pictures 2026-08-20 2-Methoxythiophene
16839-97-7
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
2-Methoxythiophene pictures 2026-03-20 2-Methoxythiophene
16839-97-7
 $9.90 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
  • 2-Methoxythiophene pictures
  • 2-Methoxythiophene
    16839-97-7
  • $1.00-200.00
  • 99%, 99.5% Sublimated
  • Henan Fengda Chemical Co., Ltd

2-Methoxythiophene Spectrum

2-Methoxythiophene(16839-97-7)MS2-Methoxythiophene(16839-97-7)1HNMR2-Methoxythiophene(16839-97-7)13CNMR2-Methoxythiophene(16839-97-7)IR12-Methoxythiophene(16839-97-7)Raman

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