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2-Methoxythiophene

2-Methoxythiophene Structure
2-Methoxythiophene structure
CAS No.
16839-97-7
Chemical Name:
2-Methoxythiophene
Synonyms
Methoxythiophene;2-METHOXYTHIOPHENE;Thiophene, 2-methoxy-;2-Methoxythiophene>2-Methoxythiophene 97%;2-Methoxythiophene,99%;2-Methoxythiophene,97%;METHYL 2-THIENYL ETHER;2-Methoxythiophene ISO 9001：2015 REACH
CBNumber:
CB2748272
Molecular Formula:
C5H6OS
Molecular Weight:
114.17
MDL Number:
MFCD00014526
MOL File:
16839-97-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:44:23
Product description Number Pack Size Price
2-Methoxythiophene 97% 331597 5g $134
2-Methoxythiophene >98.0%(GC) M1030 5g $78
2-Methoxythiophene >98.0%(GC) M1030 25g $264
2-Methoxythiophene >98% OR937091 5g $21
2-Methoxythiophene >98% OR937091 25g $41
More product size
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2-Methoxythiophene Properties

Boiling point 151-152 °C/762 mmHg (lit.)
Density 1.133 g/mL at 25 °C (lit.)
refractive index n20/D 1.528(lit.)
Flash point 110 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol (Slightly)
form clear liquid
color Colorless to Light yellow to Light orange
BRN 106271
InChI InChI=1S/C5H6OS/c1-6-5-3-2-4-7-5/h2-4H,1H3
InChIKey OKEHURCMYKPVFW-UHFFFAOYSA-N
SMILES C1(OC)SC=CC=1
LogP 2.130
CAS DataBase Reference 16839-97-7(CAS DataBase Reference)
NIST Chemistry Reference 2-Methoxythiophene(16839-97-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)
GHS02
Signal word  Warning
Hazard statements  H226
Precautionary statements  P210-P240-P241-P280a-P303+P361+P353-P501a
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Risk Statements  10
Safety Statements  16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
HazardClass  3
PackingGroup  III
HS Code  29349990
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
0 0

2-Methoxythiophene price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 331597 2-Methoxythiophene 97% 16839-97-7 5g $134 2026-04-30 Buy
TCI Chemical M1030 2-Methoxythiophene >98.0%(GC) 16839-97-7 5g $78 2026-04-30 Buy
TCI Chemical M1030 2-Methoxythiophene >98.0%(GC) 16839-97-7 25g $264 2026-04-30 Buy
Apolloscientific OR937091 2-Methoxythiophene >98% 16839-97-7 5g $21 2026-06-04 Buy
Apolloscientific OR937091 2-Methoxythiophene >98% 16839-97-7 25g $41 2026-06-04 Buy
Product number Packaging Price Buy
331597 5g $134 Buy
M1030 5g $78 Buy
M1030 25g $264 Buy
OR937091 5g $21 Buy
OR937091 25g $41 Buy

2-Methoxythiophene Chemical Properties,Uses,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

2-Methoxythiophene was used in thermal reaction (60°C) of (C5Me5)Rh(PMe3)(Ph)H.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 3697, 1953 DOI: 10.1021/ja01111a027

General Description

2-Methoxythiophene is a heterocyclic methyl enol ether and its reaction with o-quinone monoimide was studied. The intramolecular and intermolecular geometries of crystals of 2-methoxythiophene were investigated. Kinetics of the hydronium-ion catalysed hydrolysis of 2-methoxythiophene was reported.

Synthesis

2-Bromothiophene

1003-09-4

Sodium Methoxide

124-41-4

2-Methoxythiophene

16839-97-7

Example 1 Preparation of 2-methoxythiophene: In a reactor, 300 g of 2-bromothiophene (1.84 mol), 2.64 g of copper(I) bromide (CuBr, 1 mol%), 18.4 g of polyethylene glycol dimethyl ether (PEG DME 500, 2 mol%), and 660 g of a methanolic solution of sodium methanolate (30% concentration, precursor concentration of 30.6%) were added in sequence. The mixture was heated to 90 °C for the reaction and the progress of the reaction was monitored by gas chromatography (GC) until the conversion was >98% (total reaction time 8h). Upon completion of the reaction, the reaction mixture was slowly poured into 500 g of water and filtered through Decalite. Subsequently, the aqueous phase was extracted twice with methyl tert-butyl ether (MTBE, 150 g each time). The organic phases were combined and purified by vacuum fractional distillation to give a final 182 g of 2-methoxythiophene (1.59 mol, 86.4% yield) with a GC purity of >99% (% area).

References

[1] Patent: US2008/71084, 2008, A1. Location in patent: Page/Page column 3-4
[2] Synthetic Communications, 1990, vol. 20, # 2, p. 213 - 216
[3] Tetrahedron, 1992, vol. 48, # 17, p. 3633 - 3652
[4] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8651 - 8664

2-Methoxythiophene Preparation Products And Raw materials

Raw materials

2-Bromothiophene 2-Iodothiophene Methanol Sodium Methoxide

Preparation Products

3-IODOTHIOPHENE

2-Methoxythiophene Suppliers

Global( 239)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8738 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14026 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29792 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
AB PharmaTech,LLC 		55
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58

View Lastest Price from 2-Methoxythiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methoxythiophene pictures 2026-07-09 2-Methoxythiophene
16839-97-7
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
2-Methoxythiophene pictures 2026-03-20 2-Methoxythiophene
16839-97-7
 $9.90 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Methoxythiophene pictures 2025-11-18 2-Methoxythiophene
16839-97-7
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
  • 2-Methoxythiophene pictures
  • 2-Methoxythiophene
    16839-97-7
  • $1.00-200.00
  • 99%, 99.5% Sublimated
  • Henan Fengda Chemical Co., Ltd

2-Methoxythiophene Spectrum

2-Methoxythiophene(16839-97-7)MS2-Methoxythiophene(16839-97-7)1HNMR2-Methoxythiophene(16839-97-7)13CNMR2-Methoxythiophene(16839-97-7)IR12-Methoxythiophene(16839-97-7)Raman

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