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ChemicalBook >> CAS DataBase List >>1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Structure
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- structure
CAS No.
2349393-95-7
Chemical Name:
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-
Synonyms
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-
CBNumber:
CB28382933
Molecular Formula:
C24H19ClF2N4O3
Molecular Weight:
484.88
MDL Number:
MOL File:
2349393-95-7.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
Request For Quotation

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Properties

Boiling point 733.1±60.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
storage temp. Store at -20°C, protect from light, stored under nitrogen
solubility DMSO : 100 mg/mL (206.24 mM; Need ultrasonic)
form Solid
pka 6.72±0.35(Predicted)
color Light yellow to yellow

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0102606 KRAS G12C inhibitor 14 99.00% 2349393-95-7 1mg $303 2026-06-04 Buy
ChemScene CS-0102606 KRAS G12C inhibitor 14 99.00% 2349393-95-7 5mg $769 2026-06-04 Buy
ChemScene CS-0102606 KRAS G12C inhibitor 14 99.00% 2349393-95-7 10mg $1246 2026-06-04 Buy
ChemScene CS-0102606 KRAS G12C inhibitor 14 99.00% 2349393-95-7 25mg $2492 2026-06-04 Buy
ChemScene CS-0102606 KRAS G12C inhibitor 14 99.00% 2349393-95-7 50mg $4117 2026-06-04 Buy
Product number Packaging Price Buy
CS-0102606 1mg $303 Buy
CS-0102606 5mg $769 Buy
CS-0102606 10mg $1246 Buy
CS-0102606 25mg $2492 Buy
CS-0102606 50mg $4117 Buy

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Chemical Properties, Uses, Production

Uses

KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM[1].

Biological Activity

KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM[1].

IC 50

KRas G12C: 18 nM (IC50)

References

[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Aladdin Scientific tp@aladdinsci.com United States 50068 58
Supplier Advantage
BOC Sciences 65
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58

View Latest Price from 1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KRAS G12C inhibitor 14 pictures 2026-07-27 KRAS G12C inhibitor 14
2349393-95-7
 $1890.00 10g TargetMol Chemicals Inc.
KRAS G12C inhibitor 14 pictures 2026-07-27 KRAS G12C inhibitor 14
2349393-95-7
 $1890.00 10g TargetMol Chemicals Inc.
KRAS G12C inhibitor 14 pictures 2025-08-22 KRAS G12C inhibitor 14
2349393-95-7
 $1890.00 10g TargetMol Chemicals Inc.

2349393-95-7 (1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-) Related Search:

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- 2,7-Diazaspiro[4.4]nonane-2-acetamide, α-cyclopentyl-7-[[(2R,3R)-3-cyclopropyl-1-methyl-2-aziridinyl]carbonyl]-N-[(1R,10S,12S,18S)-1-[5-(4-cyclopropyl-1-piperazinyl)-2-[(1S)-1-methoxyethyl]-3-pyridinyl]-2,7,8,10,11,12,13,16,17,18,19,21,22,23-tetradecahydro-22,22-dimethyl-13,19-dioxo-2-(2,2,2-trifluoroethyl)-15H-3,5-etheno-14,18-imino-6,10-methano-6H-pyrrolo[3,4-g][1,12,4,18]dioxadiazacyclodocosin-12-yl]-, (αS,5S)- NAV2729 Y-27632 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-
RMC6291

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1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- 2349393-95-7 C24H19ClF2N4O3