3,5-Dichloro-4-Picoline
- CAS No.
- 100868-46-0
- Chemical Name:
- 3,5-Dichloro-4-Picoline
- Synonyms
- 3,5-Dichloro-4-Picoline;3,5-Dichloro-4-methylpyridine;Pyridine,3,5-dichloro-4-Methyl-;3,5-Dichloro-4-methylpyridine 97%;3,5-Dichloro-4-Picoline ISO 9001：2015 REACH
- CBNumber:
- CB31033107
- Molecular Formula:
- C6H5Cl2N
- Molecular Weight:
- 162.02
- MDL Number:
- MFCD09839290
- MOL File:
- 100868-46-0.mol
| Product description | Number | Pack Size | Price |
| 3,5-Dichloro-4-methylpyridine | D435688 | 50mg | $60 |
| 3,5-Dichloro-4-methylpyridine | FD146967 | 2g | $70 |
| 3,5-Dichloro-4-methylpyridine 97% | OR61509 | 5g | $129 |
| 3,5-Dichloro-4-methylpyridine | FD146967 | 5G | $140 |
| 3,5-Dichloro-4-methylpyridine | 3H30-5-Z3 | 5G | $152 |
| More product size | |||
| Melting point | 49 °C |
|---|---|
| Boiling point | 125-127 °C(Press: 74 Torr) |
| Density | 1.319±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 0.62±0.10(Predicted) |
| Appearance | Off-white to light brown Solid |
| InChI | InChI=1S/C6H5Cl2N/c1-4-5(7)2-9-3-6(4)8/h2-3H,1H3 |
| InChIKey | YBHYECGRNFZJPC-UHFFFAOYSA-N |
| SMILES | C1=NC=C(Cl)C(C)=C1Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933399990 |
3,5-Dichloro-4-Picoline price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D435688 | 3,5-Dichloro-4-methylpyridine | 100868-46-0 | 50mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD146967 | 3,5-Dichloro-4-methylpyridine | 100868-46-0 | 2g | $70 | 2021-12-16 | Buy |
| Apolloscientific | OR61509 | 3,5-Dichloro-4-methylpyridine 97% | 100868-46-0 | 5g | $129 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD146967 | 3,5-Dichloro-4-methylpyridine | 100868-46-0 | 5G | $140 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H30-5-Z3 | 3,5-Dichloro-4-methylpyridine | 100868-46-0 | 5G | $152 | 2021-12-16 | Buy |
3,5-Dichloro-4-Picoline Chemical Properties,Uses,Production
Synthesis
2457-47-8
74-88-4
100868-46-0
Example 6 (Scheme 1) Preparation of 3,5-dichloro-4-methylpyridine (4): diisopropylamine (70 mL, 500 mmol) was dissolved in anhydrous tetrahydrofuran (500 mL) under nitrogen protection, and the resultant solution was cooled to -10 °C and n-butyllithium (2.5 M hexane solution, 210 mL, 525 mmol) was added slowly dropwise under stirring. After the dropwise addition, stirring was continued for 30 min at -10 °C. Subsequently, the reaction system was further cooled to -20 °C and a tetrahydrofuran (200 mL) solution of 3,5-dichloropyridine (66.6 g, 450 mmol) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was stirred at -10 °C for 30 min. Next, the reaction system was cooled to -70 °C and a tetrahydrofuran (100 mL) solution of iodomethane (50 mL, 1.6 mol) was added dropwise. After the dropwise addition, the reaction mixture was slowly warmed up to room temperature. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL) and extracted with ether (3 x 100 mL). The organic layers were combined, dried over anhydrous sodium sulfate (5 g), filtered and concentrated to dryness under reduced pressure. The crude product was recrystallized by two recrystallizations from aqueous ethanol followed by hexane to give 3,5-dichloro-4-methylpyridine (49.9 g, 306 mmol, 68% yield) as a white solid.
References
[1] Patent: EP2070913, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: EP2022783, 2009, A1. Location in patent: Page/Page column 12
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 793 - 816
3,5-Dichloro-4-Picoline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20175 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8826 | 58 |
View Lastest Price from 3,5-Dichloro-4-Picoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 3,5-Dichloro-4-Picoline
100868-46-0
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-07-25 | 3,5-Dichloro-4-Picoline
100868-46-0
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2021-08-28 | 3,5-Dichloro-4-Picoline
100868-46-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 3,5-Dichloro-4-Picoline
100868-46-0
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 3,5-Dichloro-4-Picoline
100868-46-0
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3,5-Dichloro-4-Picoline
100868-46-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
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