3,5-Dichloro-4-pyridinecarbonitrile
- CAS No.
- 153463-65-1
- Chemical Name:
- 3,5-Dichloro-4-pyridinecarbonitrile
- Synonyms
- 3,5-DICHLOROISONICOTINONITRILE;4-Cyano-3,5-dichloropyridine;3,5-Dichloro-4-pyridinecarbonitrile;3,5-dichloropyridine-4-carbonitrile;4-Pyridinecarbonitrile, 3,5-dichloro-;3,5-Dichloro-4-pyridinecarbonitrile 97+%;3,5-
Dichloro- 4- pyridinecarbonitrile;3,5-DICHLORO-4-PYRIDINECARBONITRILE ISO 9001：2015 REACH
- CBNumber:
- CB4716970
- Molecular Formula:
- C6H2Cl2N2
- Molecular Weight:
- 173
- MDL Number:
- MFCD00104651
- MOL File:
- 153463-65-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 115-119 °C (lit.) |
|---|---|
| Boiling point | 266.2±35.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | solid |
| pka | -0.84±0.10(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | 1S/C6H2Cl2N2/c7-5-2-10-3-6(8)4(5)1-9/h2-3H |
| InChIKey | MUHBRCUFWMUBNP-UHFFFAOYSA-N |
| SMILES | Clc1cncc(Cl)c1C#N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H317-H318-H335 |
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41-43 |
| Safety Statements | 26-36/37/39 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| PackingGroup | Ⅲ |
| HS Code | 2933399990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
3,5-Dichloro-4-pyridinecarbonitrile price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 644196 | 3,5-Dichloro-4-pyridinecarbonitrile 97% | 153463-65-1 | 1g | $45.6 | 2023-01-07 | Buy |
| Sigma-Aldrich | 644196 | 3,5-Dichloro-4-pyridinecarbonitrile 97% | 153463-65-1 | 5g | $188 | 2023-01-07 | Buy |
| Apolloscientific | OR315205 | 3,5-Dichloro-4-pyridinecarbonitrile >98% | 153463-65-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR315205 | 3,5-Dichloro-4-pyridinecarbonitrile >98% | 153463-65-1 | 5g | $26 | 2026-06-04 | Buy |
| Apolloscientific | OR315205 | 3,5-Dichloro-4-pyridinecarbonitrile >98% | 153463-65-1 | 25g | $127 | 2026-06-04 | Buy |
3,5-Dichloro-4-pyridinecarbonitrile Chemical Properties, Uses, Production
Synthesis
136590-83-5
153463-65-1
Example 22A: 3,5-Dichloro-4-pyridinecarboxaldehyde (10.0 g, 57.1 mmol) was mixed with hydroxylamine hydrochloride (5.25 g, 76 mmol), formic acid (50 mL) and sodium bisulfate (5 drops). The mixture was refluxed for 6 hours under nitrogen protection. Upon completion of the reaction, the solvent was removed by vacuum concentration. The resulting solid was dissolved in ether (250 mL), washed sequentially with sodium bicarbonate solution and brine, and the organic phase was dried with magnesium sulfate. After filtration, the organic phase was concentrated and finally recrystallized from hexane to give 8.2 g of the target product, 3,5-dichloroisonicotinonitrile, in 83% yield with a melting point of 114 °C.
References
[1] Patent: EP1270577, 2003, A1
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 23, p. 7374 - 7388
[3] Patent: WO2006/81072, 2006, A1. Location in patent: Page/Page column 17; 37
[4] Heterocycles, 1995, vol. 41, # 4, p. 675 - 688
[5] Patent: US6232320, 2001, B1
3,5-Dichloro-4-pyridinecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Dichloro-4-pyridinecarbonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Candia Thamtech Company Limited | 0371-86615086 18203638366 0371-86159066 13526786601 | China | 2011 | 60 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
View Latest Price from 3,5-Dichloro-4-pyridinecarbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 3,5-DICHLORO-4-PYRIDINECARBONITRILE
153463-65-1
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd |
-
- 3,5-DICHLORO-4-PYRIDINECARBONITRILE
153463-65-1
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
