2,6-Dichloro-4-picoline
- CAS No.
- 39621-00-6
- Chemical Name:
- 2,6-Dichloro-4-picoline
- Synonyms
- 6-Dichloro-4-picoline;2,6-Dichloro-4-picoline;2,6-Dichloro-4-methylpyri...;Pyridine,2,6-dichloro-4-Methyl-;2,6-Dichloro-4-methylpyridine,95%;2,6-Dichloro-4-picoline ISO 9001：2015 REACH
- CBNumber:
- CB1947115
- Molecular Formula:
- C6H5Cl2N
- Molecular Weight:
- 162.02
- MDL Number:
- MFCD09264302
- MOL File:
- 39621-00-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 65.0-66.0 °C(Solv: ligroine (8032-32-4)) |
|---|---|
| Boiling point | 122-123 °C(Press: 22-23 Torr) |
| Density | 1.319±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | Solid |
| pka | -2.22±0.10(Predicted) |
| color | White |
| InChI | InChI=1S/C6H5Cl2N/c1-4-2-5(7)9-6(8)3-4/h2-3H,1H3 |
| InChIKey | GTHRJKYVJZJPCF-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC(C)=C1 |
| CAS DataBase Reference | 39621-00-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2,6-Dichloro-4-picoline price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | SC1641 | 2,6-DICHLORO-4-METHYLPYRIDINE 95% | 39621-00-6 | 5G | $18 | 2026-04-30 | Buy |
| AstaTech | SC1641 | 2,6-DICHLORO-4-METHYLPYRIDINE 95% | 39621-00-6 | 25G | $69 | 2026-04-30 | Buy |
| AstaTech | SC1641 | 2,6-DICHLORO-4-METHYLPYRIDINE 95% | 39621-00-6 | 100G | $223 | 2026-04-30 | Buy |
| Biosynth | FD54458 | 2,6-Dichloro-4-methylpyridine | 39621-00-6 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FD54458 | 2,6-Dichloro-4-methylpyridine | 39621-00-6 | 10g | $181.5 | 2026-06-04 | Buy |
2,6-Dichloro-4-picoline Chemical Properties, Uses, Production
Chemical Properties
off-white solid
Uses
2,6-Dichloro-4-methylpyridine is used in preparation of substituted phenoxymethyl benzoic acids and related products as modulators of Mas-related G-protein receptor X4.
Synthesis
52313-61-8
39621-00-6
General procedure for the synthesis of 2,6-dichloro-4-methylpyridine from 2-chloro-4-methylpyridine-N-oxide: 2-chloro-4-methylpyridine-N-oxide was added to a 50mL round-bottomed flask, and 20mL of phosphorus oxychloride (POCl3) was added slowly and dropwise. (Note: the reaction is exothermic and slow addition of N-oxide to POCl3 is required to avoid violent reaction.) Subsequently, an additional 10 mL of POCl3 was added to the reaction mixture and the reaction system was heated to 95°C and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and volatiles were removed by distillation under reduced pressure. The residue was slowly poured into 150 mL of saturated sodium bicarbonate (NaHCO3) aqueous solution and extracted with ethyl acetate (EtOAc, 3 x 50 mL). The organic phases were combined, washed with 50 mL of saturated brine and dried over anhydrous magnesium sulfate (MgSO4). The solvent was removed by concentration under reduced pressure and the resulting brown solid was purified by fast column chromatography on silica gel (eluent: 0 to 7% ethyl acetate/hexane gradient) to afford 1.56 g of the target product 2,6-dichloro-4-methylpyridine in 43% yield.
References
[1] Patent: US2004/198736, 2004, A1. Location in patent: Page/Page column 76
[2] Patent: US2011/9390, 2011, A1. Location in patent: Page/Page column 19
[3] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 1056
2,6-Dichloro-4-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiaxing Rich Biological Technology Co., Ltd. | 0573-11111111-1111 18969316891 | richmol@163.com | China | 450 | 50 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2,6-Dichloro-4-picoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,6-Dichloro-4-picoline
39621-00-6
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2,6-Dichloro-4-picoline
39621-00-6
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2,6-Dichloro-4-picoline
39621-00-6
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2,6-Dichloro-4-picoline
39621-00-6
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2,6-Dichloro-4-picoline
39621-00-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,6-Dichloro-4-picoline
39621-00-6
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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