2,3,5-Trimethylpyrazine
- CAS No.
- 14667-55-1
- Chemical Name:
- 2,3,5-Trimethylpyrazine
- Synonyms
- Pyrazine, trimethyl-;2,3,5-TRIMETHYLPYRAZINE;TRIMETHYLPYRAZINE;FEMA 3244;2,3,6-TRIMETHYLPYRAZINE;2,3,5-TriMethylpyrazine 99%;FEMA NUMBER 3244;Compound Fr14500;trimethyl-pyrazin;2.3.5-Methyl pyrazine
- CBNumber:
- CB3105641
- Molecular Formula:
- C7H10N2
- Molecular Weight:
- 122.17
- MDL Number:
- MFCD00006145
- MOL File:
- 14667-55-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 156 °C |
|---|---|
| Boiling point | 171-172 °C (lit.) |
| Density | 0.979 g/mL at 25 °C (lit.) |
| refractive index |
n |
| FEMA | 3244 | 2,3,5-TRIMETHYLPYRAZINE |
| FLAVIS Number | 14.019 | 2,3,5-Trimethylpyrazine |
| Flash point | 130 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly) |
| pka | 2.69±0.10(Predicted) |
| form | Liquid |
| color | Colorless to Light yellow to Light orange |
| Specific Gravity | 0.979 |
| Odor | roasted odor, reminiscent of coffee and cocoa |
| biological source | synthetic |
| Odor Type | nutty |
| JECFA Number | 774 |
| BRN | 2423 |
| Major Application | flavors and fragrances |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C7H10N2/c1-5-4-8-6(2)7(3)9-5/h4H,1-3H3 |
| InChIKey | IAEGWXHKWJGQAZ-UHFFFAOYSA-N |
| SMILES | Cc1cnc(C)c(C)n1 |
| LogP | 1.10 |
| CAS DataBase Reference | 14667-55-1(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 2,3,5-TRIMETHYLPYRAZINE |
| EWG's Food Scores | 1 |
| FDA UNII | Q8PR0W8TIT |
| NIST Chemistry Reference | Pyrazine, trimethyl-(14667-55-1) |
| EPA Substance Registry System | Trimethylpyrazine (14667-55-1) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 10-22-36/37/38 | |||||||||
| Safety Statements | 16-26-36/37/39 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ3907000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | rat,LD50,oral,806mg/kg (806mg/kg),Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980. | |||||||||
| NFPA 704 |
|
2,3,5-Trimethylpyrazine price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W324426 | 2,3,5-Trimethylpyrazine natural, ≥95%, FG | 14667-55-1 | 1 each | $63.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | W324426 | 2,3,5-Trimethylpyrazine natural, ≥95%, FG | 14667-55-1 | 100g | $502 | 2026-04-30 | Buy |
| Sigma-Aldrich | W324418 | 2,3,5-Trimethylpyrazine ≥99%, FCC, FG | 14667-55-1 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | W324426 | 2,3,5-Trimethylpyrazine natural, ≥95%, FG | 14667-55-1 | 1kg | $4650 | 2026-04-30 | Buy |
| Sigma-Aldrich | W324418 | 2,3,5-Trimethylpyrazine ≥99%, FCC, FG | 14667-55-1 | 100g | $83.1 | 2026-04-30 | Buy |
2,3,5-Trimethylpyrazine Chemical Properties,Uses,Production
Chemical Properties
2,3,5-Trimethylpyrazine is a clear yellow liquid that has a baked potato or roasted nut aroma.
Occurrence
Reported present in bakery products, roasted barley, cocoa products, coffee, dairy products, meat, peanuts, filberts, pecans, popcorn, potato products, rum and whiskey, soy products, raw asparagus, baked potato, wheaten bread, crispbread, Swiss cheese, coffee, black tea, green tea, roasted barley, roasted filbert, heated beef, roasted peanut, soybean, raw beans, coriander seed, scallop, guava, kohlrabi, bell pepper, blue, Swiss and Gruyere cheese, boiled egg, fatty fish, beer, sherry, barley, peanut, oat products, coconut, beans, mushroom, trassi, almond, macadamia nut, sesame seed, coriander seed, rice, licorice, sweet corn, malt, peated malt, wort, krill, fermented shrimp, crab, okra, crayfish, clam, scallop and squid.
Uses
Trimethylpyrazine is a key aroma compound of dark chocolates differing in organoleptic properties.
Uses
2,3,5-Trimethylpyrazine can be used as a flavor ingredient in food industries.
Definition
ChEBI: Trimethylpyrazine is a member of the class of pyrazines that is pyrazine in which three hydrogens at positions 2, 3 and 5 have been replaced by methyl groups. It has a role as a plant metabolite, a flavouring agent, a bacterial metabolite, an animal metabolite and a pheromone.
Preparation
From 2,5-dimethylpyrazine by ring alkylation with MeLi; by condensing propylenediamine with 2,3-butanedione.
Aroma threshold values
Detection: 400 ppb to 9 ppm (9 ppm in water)
Taste threshold values
Taste characteristics at 80 ppm: raw, musty, nutty and potato.
General Description
2,3,5-Trimethylpyrazine is present in brown cheese.
Safety Profile
Moderately toxic by ingestion. Combustible liquid. When heated to decomposition emits toxic fumes of NOx.
2,3,5-Trimethylpyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Jiecheng Chemical Co., Ltd. | 15868606025 | 2598306141@qq.com | China | 100 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 2,3,5-Trimethylpyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Trimethyl-pyrazine
14667-55-1
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | Trimethyl-pyrazine
14667-55-1
|
$10.00 | 1KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-20 | Trimethyl-pyrazine
14667-55-1
|
$15.00-25.00 | 1kg | 99% | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Trimethyl-pyrazine
14667-55-1
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- Trimethyl-pyrazine
14667-55-1
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Trimethyl-pyrazine
14667-55-1
- $15.00-25.00
- 99%
- Hebei Yanxi Chemical Co., Ltd.
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