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4-Aminopyrazolo[3,4-d]pyrimidine

4-Aminopyrazolo[3,4-d]pyrimidine structure

CAS No.: 2380-63-4

Chemical Name:: 4-Aminopyrazolo[3,4-d]pyrimidine

Synonyms: 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE

CBNumber:: CB3112436

Molecular Formula:: C5H5N5

Molecular Weight:: 135.13

MDL Number:: MFCD00005688

MOL File:: 2380-63-4.mol

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
4-Aminopyrazolo[3,4-d]pyrimidine >97.0%(HPLC)(T)	A1041	100mg	$33
4-Aminopyrazolo[3,4-d]pyrimidine	A1041	1G	$44
4-Aminopyrazolo[3,4-d]pyrimidine	A1041	5G	$132
4-Aminopyrazolo[3,4-d]pyrimidine	A628970	1g	$50
4-Aminopyrazolo[3,4-d]pyrimidine	A628970	5g	$80
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4-Aminopyrazolo[3,4-d]pyrimidine Properties

Melting point	>325 °C(lit.)
Boiling point	238.81°C (rough estimate)
Density	1.3795 (rough estimate)
refractive index	1.7000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in DMSO
form	powder to crystal
pka	12.12±0.20(Predicted)
color	White to Orange to Green
Water Solubility	Insoluble in water.
BRN	5824
InChIKey	LHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference	2380-63-4(CAS DataBase Reference)
FDA UNII	0356MAT9LX
NIST Chemistry Reference	1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System	1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS07

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P301+P310a-P321-P501a-P261-P301+P310-P305+P351+P338

Hazard Codes

Risk Statements

25-36/37/38-23/24/25

Safety Statements

26-36/37/39-45-22-36

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

UR0717000

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29335990

Toxicity

LD50 oral in rat: 141mg/kg

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	0
3		0

4-Aminopyrazolo[3,4-d]pyrimidine price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine >97.0%(HPLC)(T)	2380-63-4	100mg	$33	2025-07-31	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	1G	$44	2025-07-31	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	5G	$132	2025-07-31	Buy
TRC	A628970	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	1g	$50	2021-12-16	Buy
TRC	A628970	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	5g	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
A1041	100mg	$33	Buy
A1041	1G	$44	Buy
A1041	5G	$132	Buy
A628970	1g	$50	Buy
A628970	5g	$80	Buy

4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties,Uses,Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

Hazard

4-Aminopyrazolo[3,4-d]pyrimidine is harmful, irritating to the eyes and skin, and may cause respiratory irritation by inhalation. It is toxic if swallowed.

Synthesis

5399-92-8

2380-63-4

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine (200 mg, 1.29 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 2.0 mL). Subsequently, ammonium hydroxide (2.0 mL) was added to this solution. The reaction mixture was stirred at 20 to 30 °C for 2 hours. After the reaction was completed, the mixture was concentrated. The concentrate was ground with acetonitrile (MeCN, 0.5 mL) and the product was subsequently collected by filtration to afford 4-aminopyrazolo[3,4-d]pyrimidine (37) as a red solid (100 mg, 57% yield).

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

formamide Formamidine acetate Formaldehyde 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine 3-Amino-4-pyrazolecarbonitrile

Ammonium hydroxide Tetrahydrofuran

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Preparation Products

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Global( 441)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou uniringchem Co., Ltd.	+undefined13585446801	sales@uniringchem.com	China	69	58
Taizhou Creating Bio-pharm co., ltd.	0576-88827176; +8613586099526	post@creatingbiopharm.com	China	219	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20176	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	883	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13469	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55

Supplier	Advantage
Changzhou uniringchem Co., Ltd.	58
Taizhou Creating Bio-pharm co., ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Shaanxi Xianhe Biotech Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 4-Aminopyrazolo[3,4-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-13	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4	US $0.00 / kg	1kg	0.99	1000kg	Shaanxi Xianhe Biotech Co., Ltd
2025-10-11	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4	US $5.00-0.10 / KG	1KG	98%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
US $0.00 / kg
0.99
Shaanxi Xianhe Biotech Co., Ltd

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
US $5.00-0.10 / KG
98%
Henan Fengda Chemical Co., Ltd

4-Aminopyrazolo[3,4-d]pyrimidine Spectrum

4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)¹HNMR 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)Raman 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)IR

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TIMTEC-BB SBB004205 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ADENINE ANTIMETABOLITE 4- aMinopyrazolo [3,4-d] pyriMidines PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-Amino-1H-pyrazolo[3,4-d]pyrimidine,98% 1(H)-4-amine-pyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 98% 1H-pyrazolo[4,3-e]pyrimidin-4-amine 1H-pyrazolo[4,3-e]pyrimidin-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 4-Aminopyra 1H-Pyrazolo[3,4-d]pyrimidine, 4-amino- 4 APP 4-Aminopyrazole(3,4-d)pyrimidine 4-Aminopyrazolopyrimidine 4-app 4-d)pyrimidine,4-amino-1h-pyrazolo( NSC 1393 nsc1393 Pyrazoloadenine 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI) Adenine antimetabolite, Pyrazolo[3,4-d]pyrimidin-4-amin Aminopurinol 4-Amino-1,2,5,7-tetraaza-1H-indene 4-Aminopyrazolo[3,4-d]pyrimidine,98% 4-AMinopyrazolo[3,4-d]pyriMidine, 97.5% Pyrazolo[3,4-d]pyrimidin-4-amin 4-Aminopyrazolo[3,4-d]pyrimidine > 4-Dihydroxybenzylamine hydrobromide 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI, ACI) 4-aminopyrazole and [3,4-d] pyrimidine IbrutinibIntermediate5 Pyrazoloadenine, 10 mM in DMSO 1H-Pyrazolo[3,4-d]pyrimidin-4-am 2380-63-4 Building Blocks Heterocyclic Building Blocks Pyrimidines Heterocyclic Compounds Heterocycles PYRIMIDINE Pyridines, Pyrimidines, Purines and Pteredines Heterocycle-Pyrimidine series