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4-Aminopyrazolo[3,4-d]pyrimidine

4-Aminopyrazolo[3,4-d]pyrimidine structure

CAS No.: 2380-63-4

Chemical Name:: 4-Aminopyrazolo[3,4-d]pyrimidine

Synonyms: 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE

CBNumber:: CB3112436

Molecular Formula:: C5H5N5

Molecular Weight:: 135.13

MDL Number:: MFCD00005688

MOL File:: 2380-63-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-30 10:48:35

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4-Aminopyrazolo[3,4-d]pyrimidine Properties

Melting point	>325 °C(lit.)
Boiling point	238.81°C (rough estimate)
Density	1.3795 (rough estimate)
refractive index	1.7000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in DMSO
pka	12.12±0.20(Predicted)
form	powder to crystal
color	White to Orange to Green
Water Solubility	Insoluble in water.
BRN	5824
InChI	1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)
InChIKey	LHCPRYRLDOSKHK-UHFFFAOYSA-N
SMILES	Nc1ncnc2[nH]ncc12
CAS DataBase Reference	2380-63-4(CAS DataBase Reference)
FDA UNII	0356MAT9LX
NIST Chemistry Reference	1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System	1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS07

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P301+P310a-P321-P501a-P261-P301+P310-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

25-36/37/38-23/24/25

Safety Statements

26-36/37/39-45-22-36

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

UR0717000

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29335990

Storage Class

6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

LD50 oral in rat: 141mg/kg

REACH Registrations

Inactive

Limited Quantities

5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	0
3		0

4-Aminopyrazolo[3,4-d]pyrimidine price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine >97.0%(HPLC)(T)	2380-63-4	100mg	$28	2026-04-30	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	1G	$37	2026-04-30	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	5G	$112	2026-04-30	Buy
Usbiological	A1380-19	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	1g	$319	2026-06-03	Buy
Usbiological	260097	4-Aminopyrazolo[3,4-d]pyrimidine Asreported	2380-63-4	2g	$326	2026-06-03	Buy

Product number	Packaging	Price	Buy
A1041	100mg	$28	Buy
A1041	1G	$37	Buy
A1041	5G	$112	Buy
A1380-19	1g	$319	Buy
260097	2g	$326	Buy

4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties, Uses, Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

Hazard

4-Aminopyrazolo[3,4-d]pyrimidine is harmful, irritating to the eyes and skin, and may cause respiratory irritation by inhalation. It is toxic if swallowed.

Synthesis

5399-92-8

2380-63-4

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine (200 mg, 1.29 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 2.0 mL). Subsequently, ammonium hydroxide (2.0 mL) was added to this solution. The reaction mixture was stirred at 20 to 30 °C for 2 hours. After the reaction was completed, the mixture was concentrated. The concentrate was ground with acetonitrile (MeCN, 0.5 mL) and the product was subsequently collected by filtration to afford 4-aminopyrazolo[3,4-d]pyrimidine (37) as a red solid (100 mg, 57% yield).

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

formamide Formamidine acetate Formaldehyde 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine 3-Amino-4-pyrazolecarbonitrile

Ammonium hydroxide Tetrahydrofuran

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Preparation Products

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Global Suppliers ( 446)

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.	028-85755578 18140172005	sales@aminotp.com	China	296	58
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	1846	58
XIANBAISI BIOPHARMACEUTICAL	19109577350	19109577350@163.com	China	35	58
Nanbu County Chengxin Technology Co., Ltd.	0838-5675166 15883665058	nbcxkj@126.com	China	956	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.	58
Suzhou Highfine Biotech Co., Ltd	58
XIANBAISI BIOPHARMACEUTICAL	58
Nanbu County Chengxin Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from 4-Aminopyrazolo[3,4-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-08-25	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4		1kg	0.99	1000kg	Shaanxi Xianhe Biotech Co., Ltd
2026-08-20	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
$5.00
98%
Henan Fengda Chemical Co., Ltd

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
$0.00
0.99
Shaanxi Xianhe Biotech Co., Ltd

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
$1.10
99.00%
Dideu Industries Group Limited

4-Aminopyrazolo[3,4-d]pyrimidine Spectrum

4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)¹HNMR 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)Raman 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)IR

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TIMTEC-BB SBB004205 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ADENINE ANTIMETABOLITE 4- aMinopyrazolo [3,4-d] pyriMidines PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-Amino-1H-pyrazolo[3,4-d]pyrimidine,98% 1(H)-4-amine-pyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 98% 1H-pyrazolo[4,3-e]pyrimidin-4-amine 1H-pyrazolo[4,3-e]pyrimidin-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 4-Aminopyra 1H-Pyrazolo[3,4-d]pyrimidine, 4-amino- 4 APP 4-Aminopyrazole(3,4-d)pyrimidine 4-Aminopyrazolopyrimidine 4-app 4-d)pyrimidine,4-amino-1h-pyrazolo( NSC 1393 nsc1393 Pyrazoloadenine 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI) Adenine antimetabolite, Pyrazolo[3,4-d]pyrimidin-4-amin Aminopurinol 4-Amino-1,2,5,7-tetraaza-1H-indene 4-Aminopyrazolo[3,4-d]pyrimidine,98% 4-AMinopyrazolo[3,4-d]pyriMidine, 97.5% Pyrazolo[3,4-d]pyrimidin-4-amin 4-Aminopyrazolo[3,4-d]pyrimidine > 4-Dihydroxybenzylamine hydrobromide 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI, ACI) 4-aminopyrazole and [3,4-d] pyrimidine IbrutinibIntermediate5 Pyrazoloadenine, 10 mM in DMSO 1H-Pyrazolo[3,4-d]pyrimidin-4-am 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 2380-63-4 Building Blocks Heterocyclic Building Blocks Pyrimidines Heterocyclic Compounds Heterocycles PYRIMIDINE Pyridines, Pyrimidines, Purines and Pteredines Heterocycle-Pyrimidine series