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H-Thr(tBu)-OtBu

H-Thr(tBu)-OtBu structure

CAS No.: 5854-78-4

Chemical Name:: H-Thr(tBu)-OtBu

Synonyms: Glu(OtBu)-OMe.HCl;O-TERT-BUTYL-L-THREONINE TERT-BUTYL ESTER;L-Thr(tBu)-OtBu;H-Thr(otbu)otbu;H-Thr(tBu)-OtBu;THREONINE(TBU)-OTBU;H-Thr(tBu)-OtBu (Syrup);H-THR(TBU)-OTBU USP/EP/BP;O-T-BUTYL-L-THREONINE T-BUTYL ESTER;O-TERT-BUTYL-L-THREONINET-BUTYLESTER

CBNumber:: CB3138414

Molecular Formula:: C12H25NO3

Molecular Weight:: 231.33

MDL Number:: MFCD00077109

MOL File:: 5854-78-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:33

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H-Thr(tBu)-OtBu Properties

Melting point	74-75 °C
Boiling point	70°C/0.8mmHg(lit.)
Density	0.959±0.06 g/cm3(Predicted)
refractive index	1.4320-1.4360
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka	6.14±0.33(Predicted)
form	clear liquid
color	Colorless to Red to Green
InChI	InChI=1S/C12H25NO3/c1-8(15-11(2,3)4)9(13)10(14)16-12(5,6)7/h8-9H,13H2,1-7H3/t8-,9+/m1/s1
InChIKey	PPDIUNOGUIAFLV-BDAKNGLRSA-N
SMILES	C(OC(C)(C)C)(=O)[C@H]([C@H](OC(C)(C)C)C)N
CAS DataBase Reference	5854-78-4

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H227
Precautionary statements	P210-P280-P370+P378-P403+P235-P501
HS Code	2922.50.5000

H-Thr(tBu)-OtBu price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B3340	O-tert-Butyl-L-threonine tert-Butyl Ester >96.0%(T)	5854-78-4	5g	$58	2026-04-30	Buy
TCI Chemical	B3340	O-tert-Butyl-L-threonine tert-Butyl Ester >96.0%(T)	5854-78-4	25g	$187	2026-04-30	Buy
Usbiological	291074	O-tert-Butyl-L-threonine tert-butyl ester	5854-78-4	25g	$347	2026-06-03	Buy
Usbiological	291074	O-tert-Butyl-L-threonine tert-butyl ester	5854-78-4	50g	$531	2026-06-03	Buy
Usbiological	291074	O-tert-Butyl-L-threonine tert-butyl ester	5854-78-4	100g	$814	2026-06-03	Buy

Product number	Packaging	Price	Buy
B3340	5g	$58	Buy
B3340	25g	$187	Buy
291074	25g	$347	Buy
291074	50g	$531	Buy
291074	100g	$814	Buy

H-Thr(tBu)-OtBu Chemical Properties, Uses, Production

Chemical Properties

Light yellowish liquid

Uses

O-tert-Butylthreonine tert-Butyl Ester, can be used in the synthesis of various chemical compounds having therapeutic activity, such as N-[[[(1S)-1-[3-(2-Pyrazinyl)-1,2,4-oxadiazol-5-yl]-3-butyn-1-yl]amino]carbonyl]-L-threonine (P842605), used as immune modeulators.

Synthesis

72-19-5

115-11-7

5854-78-4

(1) Add 250 μL of bis-L-threonine and 1750 g of ethylene glycol dimethyl ether to a 5000 mL three-neck flask. After cooling the flask to -10 to -5 °C, 1000 g of trifluoromethanesulfonic acid was slowly added dropwise at -5 to 5 °C. (2) To the reaction mixture was added 1250 g of isobutene at -15 to -10 °C. The reaction temperature was controlled at -15 to -10°C for 48 hours. (3) Upon completion of the reaction, 2500 g of water was added to the reaction mixture at -5 to 5 °C, followed by 1500 g of 20-25% ammonia to adjust the pH to 7.5-8.0. The aqueous phase was extracted with 1000 mL of ether in two portions and the organic phases were combined. The organic phase was washed three times with 250 mL of water and dried by adding 50 g of anhydrous sodium sulfate. Concentrate to dryness under reduced pressure at 50 °C to obtain 360 g of crude product with 95% purity (GC) and 70.44% yield. Purification of crude product: 360 g of crude product was dissolved in 1500 g of hexane, 5 g of activated carbon was added, decolorized at 25-35 °C for 1 h, filtered, and the filter cake was washed with 150 g of hexane. To the filtrate was added 93.0 g of glacial acetic acid (calculated amount: 360 x 95% ÷ 231.33 x 1.05 x 60 = 88.0 g), stirred at 15-25 °C for 2 h, and then slowly cooled to 0-5 °C and kept for 2 h. The filtrate was then dried for 1 h and then dried for 2 h. The crystals were separated by centrifugation and rinsed with a small amount of hexane. The wet crystals were dried under vacuum at 45 °C to give 415 g of product with 99.40% purity and 67.87% yield. Dissolve 415 g of the acetate product in 800 g of water, add 500 mL of hexane and stir to dissolve, add about 120 g of sodium bicarbonate to adjust the pH to 7.5-8.0. Separate the phases, and the aqueous phase was extracted twice consecutively with 500 mL of hexane. The organic phases were combined, washed three times with 300 mL of water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 326.20 g of liquid product with 99.69% purity and 67.20% yield.

References

[1] Patent: CN106478439, 2017, A. Location in patent: Paragraph 0028; 0029; 0030; 0031; 0032; 0033; 0034-0047
[2] Patent: WO2005/23756, 2005, A1. Location in patent: Page/Page column 5

H-Thr(tBu)-OtBu Preparation Products And Raw materials

Raw materials

L-Threonine tert-Butyl methyl ether Isobutylene 1,2-Dimethoxyethane Trifluoromethanesulfonic acid

Preparation Products

H-Thr(tBu)-OtBu Suppliers

Global Suppliers ( 188)

Supplier	Tel	Email	Country	ProdList	Advantage
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	0838-2809458 13350585791	pharm@biots.cn	China	774	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Enantiotech Corporation Ltd	760-85282375 15900088539	sale02@enantiotech.com	China	84	55
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Ark Pharm, Inc.	56
Enantiotech Corporation Ltd	55
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64

View Latest Price from H-Thr(tBu)-OtBu manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-03-20	H-THR(TBU)-OTBU 5854-78-4		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
	2019-07-06	H-THR(TBU)-OTBU 5854-78-4	$1.00	1KG	99%	20kg	Career Henan Chemical Co

H-THR(TBU)-OTBU
5854-78-4
99%
Hebei Chuanghai Biotechnology Co., Ltd

H-THR(TBU)-OTBU
5854-78-4
$1.00
99%
Career Henan Chemical Co

H-Thr(tBu)-OtBu Spectrum

H-THR(TBU)-OTBU(5854-78-4)¹HNMR

5854-78-4 (H-Thr(tBu)-OtBu) Related Search:

H-Thr(Bzl)-OH H-Thr(tBu)-OMe HCl H-Thr(tBu)-OtBu.AcOH O-tert-Butyl-L-serine methyl ester hydrochloride Thr(tBu)-OtBu

H-Thr(tBu)-OH H-Thr(tBu)-OtBu H-Ser(tBu)-OH L-Threonine methyl ester Z-Thr(tBu)-OtBu

O-Methyl-L-threonine H-Thr(tBu)-OtBu HCl H-Ser(tBu)-OtBu tert-Butyl 3-hydroxypropionate H-Thr(tBu)-OtBu AcOH

O-tert-Butyl-L-threonine tert-butyl ester tartrate H-Thr(tBu)-OtBu·HCl, O-t-butyl-L-threonine t-butyl ester hydrochloride H-Thr(Tbu)-Otbu.Hac

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H-Thr(otbu)otbu O-T-BUTYL-L-THREONINE T-BUTYL ESTER THREONINE(TBU)-OTBU O-TERT-BUTYL-L-THREONINET-BUTYLESTER (2S,3R)-tert-Butyl 2-aMino-3-(tert-butoxy)butanoate L-Thr(tBu)-OtBu L-Threonine,O-(1,1-diMethylethyl)-, 1,1-diMethylethyl ester O-tert-Butyl-L-threonine tert-butyl ester, >=97% O-tert-Butylthreoninetert-butyl ester O-tert-Butyl-L-threonine-tert-butyl ester≥ 99% (GC) H-Thr(tBu)-OtBu (Syrup) O-tert-Butyl-L-threonine tert-Butyl Ester > H-THR(TBU)-OTBU USP/EP/BP O-Tert-Butyl-L-Threoninet-Butylester or H-Thr(TBU)-OTBU Glu(OtBu)-OMe.HCl O-TERT-BUTYL-L-THREONINE TERT-BUTYL ESTER H-Thr(tBu)-OtBu 5854-78-4 C12H25NO3