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Methyl 5-bromo-6-chloropyridine-3-carboxylate

Methyl 5-bromo-6-chloropyridine-3-carboxylate structure

CAS No.: 78686-77-8

Chemical Name:: Methyl 5-bromo-6-chloropyridine-3-carboxylate

Synonyms: METHYL 5-BROMO-6-CHLORONICOTINATE;Methyl 5-bromo-6-chl;5-Bromo-6-Chloro methyl nicotinate;Methyl-5-bromo-6-chloronicotinic acid;5-bromo-3-methoxy-1,2-dihydropyridin-2-one;5-BROMO-6-CHLORONICOTINIC ACID METHYL ESTER;Methyl 5-bromo-6-chloropyridin-3-carboxylate;methyl 5-bromo-6-chloropyridine-3-carboxylate;Methyl 3-bromo-2-chloropyridine-5-carboxylate;3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester

CBNumber:: CB3148598

Molecular Formula:: C7H5BrClNO2

Molecular Weight:: 250.48

MDL Number:: MFCD03844855

MOL File:: 78686-77-8.mol

MSDS File:: SDS

Last updated:2026-05-28 01:02:30

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Methyl 5-bromo-6-chloropyridine-3-carboxylate Properties

Melting point	75-77°C
Boiling point	279.2±35.0 °C(Predicted)
Density	1.684
refractive index	1.568
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	-2.84±0.10(Predicted)
color	White to Off-White
InChI	InChI=1S/C7H5BrClNO2/c1-12-7(11)4-2-5(8)6(9)10-3-4/h2-3H,1H3
InChIKey	WINGWVOUOFMOJQ-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C(Br)C=C1C(OC)=O
CAS DataBase Reference	78686-77-8

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335-H302

Precautionary statements

P301+P312+P330-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi,Xn

Risk Statements

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	1
2		0

Methyl 5-bromo-6-chloropyridine-3-carboxylate price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	52382	METHYL 5-BROMO-6-CHLORONICOTINATE 97%	78686-77-8	5G	$33	2026-04-30	Buy
AstaTech	52382	METHYL 5-BROMO-6-CHLORONICOTINATE 97%	78686-77-8	25G	$105	2026-04-30	Buy
AstaTech	52382	METHYL 5-BROMO-6-CHLORONICOTINATE 97%	78686-77-8	100G	$380	2026-04-30	Buy
Apolloscientific	OR13854	Methyl 5-bromo-6-chloronicotinate ≥95%	78686-77-8	1g	$21	2026-06-04	Buy
Apolloscientific	OR13854	Methyl 5-bromo-6-chloronicotinate ≥95%	78686-77-8	5g	$33	2026-06-04	Buy

Product number	Packaging	Price	Buy
52382	5G	$33	Buy
52382	25G	$105	Buy
52382	100G	$380	Buy
OR13854	1g	$21	Buy
OR13854	5g	$33	Buy

Methyl 5-bromo-6-chloropyridine-3-carboxylate Chemical Properties,Uses,Production

Uses

Methyl 5-Bromo-6-chloronicotinate can be used to treat diseases related to S1PR1.

Synthesis

29241-62-1

74-88-4

Methyl 5-bromo-6-chloropyridine-3-carboxylate

78686-77-8

Step 1: Synthesis of methyl 5-bromo-6-chloronicotinate (61). A mixture of 5-bromo-6-chloronicotinic acid (60) (0.2 g, 0.84 mmol), potassium carbonate (K2CO3) (0.3 g, 2.1 mmol) and iodomethane (0.178 g, 1.2 mmol) in N,N-dimethylformamide (DMF) (10 mL) was stirred for 16 h at 0 °C and subsequently raised to room temperature. Upon completion of the reaction, the reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (EtOAc) (2 x 20 mL). The organic phases were combined and washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) (20 mL) and brine (2 x 20 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated to afford the target product methyl 5-bromo-6-chloronicotinate (61) (0.2 g, 94.7% yield).

References

[1] Patent: WO2017/4608, 2017, A1. Location in patent: Paragraph 0183

Methyl 5-bromo-6-chloropyridine-3-carboxylate synthesis

Synthesis of Methyl 5-bromo-6-chloropyridine-3-carboxylate from 5-Bromo-6-chloronicotinic acid and Iodomethane

Methyl 5-bromo-6-chloropyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

5-Bromo-6-chloronicotinic acid Methyl 5-bromo-6-hydroxynicotinate Iodomethane (Trimethylsilyl)diazomethane N,N-Dimethylformamide

Potassium carbonate

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Preparation Products

Methyl 5-bromo-6-chloropyridine-3-carboxylate Suppliers

Global( 235)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Guide Fine Material Co., Ltd.	13914021065 13912645265	lixm@guide-chemicals.com	China	236	58
Anqing Duohui Biotechnology Co., Ltd.	19121697802	sales@hope-chem.com	China	264	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
Suzhou Guide Fine Material Co., Ltd.	58
Anqing Duohui Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64

View Lastest Price from Methyl 5-bromo-6-chloropyridine-3-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	Methyl 5-bromo-6-chloropyridine-3-carboxylate 78686-77-8	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-08-20	Methyl 5-bromo-6-chloropyridine-3-carboxylate 78686-77-8	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-06-30	methyl 5-bromo-6-chloronicotinate 78686-77-8		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Methyl 5-bromo-6-chloropyridine-3-carboxylate
78686-77-8
$5.00
98%
Henan Fengda Chemical Co., Ltd

Methyl 5-bromo-6-chloropyridine-3-carboxylate
78686-77-8
$1.10
99.00%
Dideu Industries Group Limited

methyl 5-bromo-6-chloronicotinate
78686-77-8
98.0%
Shaanxi Dideu New Materials Co. Ltd

Methyl 5-bromo-6-chloropyridine-3-carboxylate Spectrum

Methyl 5-bromo-6-chloropyridine-3-carboxylate(78686-77-8)¹HNMR Methyl 5-bromo-6-chloropyridine-3-carboxylate(78686-77-8)FT-IR

78686-77-8(Methyl 5-bromo-6-chloropyridine-3-carboxylate)Related Search:

Kresoxim-methyl 3-Bromoanisole Methyl formate Methylparaben Methyl 6-chloronicotinate

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Chlorobromoisocyanurate 1-Bromo-3-chloro-5,5-dimethylhydantoin Methyl nicotinate METHYL 5-BROMO-2-CHLOROPYRIDINE-3-CARBOXYLATE Acetonitrile

Methyl 2-chloronicotinate Chlorodibromomethane Methyl

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methyl 5-bromo-6-chloropyridine-3-carboxylate 5-BROMO-6-CHLORONICOTINIC ACID METHYL ESTER Methyl 3-bromo-2-chloropyridine-5-carboxylate Methyl 5-bromo-6-chloropyridine-3-carboxylate, Methyl 3-bromo-2-chloropyridine-5-carboxylate 3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester Methyl 5-bromo-6-chloropyridine-3-carboxylate ISO 9001：2015 REACH Methyl 5-bromo-6-chl Methyl-5-bromo-6-chloronicotinic acid 5-bromo-3-methoxy-1,2-dihydropyridin-2-one 5-Bromo-6-Chloro methyl nicotinate 3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester (9CI, ACI) 5-bromo-6-chloro-3-Pyridinecarboxylic acid methyl ester (9CI ACI) Methyl 5-bromo-6-chloropyridin-3-carboxylate METHYL 5-BROMO-6-CHLORONICOTINATE 78686-77-8 Esters Pyridines Pyridine API intermediates