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Methyl 5-bromo-6-chloropyridine-3-carboxylate

Methyl 5-bromo-6-chloropyridine-3-carboxylate structure

CAS No.: 78686-77-8

Chemical Name:: Methyl 5-bromo-6-chloropyridine-3-carboxylate

Synonyms: Methyl 5-bromo-6-chl;METHYL 5-BROMO-6-CHLORONICOTINATE;5-Bromo-6-Chloro methyl nicotinate;Methyl-5-bromo-6-chloronicotinic acid;5-bromo-3-methoxy-1,2-dihydropyridin-2-one;5-BROMO-6-CHLORONICOTINIC ACID METHYL ESTER;methyl 5-bromo-6-chloropyridine-3-carboxylate;Methyl 3-bromo-2-chloropyridine-5-carboxylate;3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester;Methyl 5-bromo-6-chloropyridine-3-carboxylate ISO 9001：2015 REACH

CBNumber:: CB3148598

Molecular Formula:: C7H5BrClNO2

Molecular Weight:: 250.48

MDL Number:: MFCD03844855

MOL File:: 78686-77-8.mol

Last updated:2025-08-28 17:34:51

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Methyl 5-bromo-6-chloropyridine-3-carboxylate Properties

Melting point	75-77°C
Boiling point	279.2±35.0 °C(Predicted)
Density	1.684
refractive index	1.568
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	-2.84±0.10(Predicted)
color	White to Off-White
InChI	InChI=1S/C7H5BrClNO2/c1-12-7(11)4-2-5(8)6(9)10-3-4/h2-3H,1H3
InChIKey	WINGWVOUOFMOJQ-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C(Br)C=C1C(OC)=O
CAS DataBase Reference	78686-77-8

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335-H302

Precautionary statements

P301+P312+P330-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi,Xn

Risk Statements

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	1
2		0

Methyl 5-bromo-6-chloropyridine-3-carboxylate price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M295945	Methyl5-bromo-6-chloronicotinate	78686-77-8	100mg	$45	2021-12-16	Buy
TRC	M295945	Methyl5-bromo-6-chloronicotinate	78686-77-8	500mg	$65	2021-12-16	Buy
Usbiological	455683	Methyl 5-bromo-6-chloronicotinate	78686-77-8	100mg	$305	2021-12-16	Buy
AK Scientific	J51363	Methyl5-bromo-6-chloronicotinate	78686-77-8	100g	$330	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0026506	METHYL 5-BROMO-6-CHLORONICOTINATE 95.00%	78686-77-8	1G	$771.89	2021-12-16	Buy

Product number	Packaging	Price	Buy
M295945	100mg	$45	Buy
M295945	500mg	$65	Buy
455683	100mg	$305	Buy
J51363	100g	$330	Buy
HCH0026506	1G	$771.89	Buy

Methyl 5-bromo-6-chloropyridine-3-carboxylate Chemical Properties,Uses,Production

Uses

Methyl 5-Bromo-6-chloronicotinate can be used to treat diseases related to S1PR1.

Synthesis

29241-62-1

74-88-4

Methyl 5-bromo-6-chloropyridine-3-carboxylate

78686-77-8

Step 1: Synthesis of methyl 5-bromo-6-chloronicotinate (61). A mixture of 5-bromo-6-chloronicotinic acid (60) (0.2 g, 0.84 mmol), potassium carbonate (K2CO3) (0.3 g, 2.1 mmol) and iodomethane (0.178 g, 1.2 mmol) in N,N-dimethylformamide (DMF) (10 mL) was stirred for 16 h at 0 °C and subsequently raised to room temperature. Upon completion of the reaction, the reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (EtOAc) (2 x 20 mL). The organic phases were combined and washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) (20 mL) and brine (2 x 20 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated to afford the target product methyl 5-bromo-6-chloronicotinate (61) (0.2 g, 94.7% yield).

References

[1] Patent: WO2017/4608, 2017, A1. Location in patent: Paragraph 0183

Methyl 5-bromo-6-chloropyridine-3-carboxylate synthesis

Synthesis of Methyl 5-bromo-6-chloropyridine-3-carboxylate from 5-Bromo-6-chloronicotinic acid and Iodomethane

Methyl 5-bromo-6-chloropyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

5-Bromo-6-chloronicotinic acid METHYL 5-BROMO-6-HYDROXYNICOTINATE Iodomethane (TRIMETHYLSILYL)DIAZOMETHANE N,N-Dimethylformamide

Potassium carbonate

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Preparation Products

Methyl 5-bromo-6-chloropyridine-3-carboxylate Suppliers

Global( 229)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Changzhou Guiding Bio-Tech. Co.,Ltd.	+86-519-519-86686860 +8618795626222	ning@guiding-bio.com	China	299	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20190	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Changzhou Guiding Bio-Tech. Co.,Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Methyl 5-bromo-6-chloropyridine-3-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-29	Methyl 5-bromo-6-chloronicotinate?? 78686-77-8	US $0.00-0.00 / kg	1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.
2025-07-25	methyl 5-bromo-6-chloronicotinate 78686-77-8	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2024-04-09	Methyl 5-bromo-6-chloropyridine-3-carboxylate 78686-77-8	US $5.00-0.10 / KG	1KG	98%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Methyl 5-bromo-6-chloronicotinate??
78686-77-8
US $0.00-0.00 / kg
99%
Jinan Ruitong Biotech Co., Ltd.

methyl 5-bromo-6-chloronicotinate
78686-77-8
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

Methyl 5-bromo-6-chloropyridine-3-carboxylate
78686-77-8
US $5.00-0.10 / KG
98%
Henan Fengda Chemical Co., Ltd

Methyl 5-bromo-6-chloropyridine-3-carboxylate Spectrum

Methyl 5-bromo-6-chloropyridine-3-carboxylate(78686-77-8)¹HNMR Methyl 5-bromo-6-chloropyridine-3-carboxylate(78686-77-8)FT-IR

78686-77-8(Methyl 5-bromo-6-chloropyridine-3-carboxylate)Related Search:

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METHYL 5-BROMO-6-CHLORONICOTINATE methyl 5-bromo-6-chloropyridine-3-carboxylate 5-BROMO-6-CHLORONICOTINIC ACID METHYL ESTER Methyl 3-bromo-2-chloropyridine-5-carboxylate Methyl 5-bromo-6-chloropyridine-3-carboxylate, Methyl 3-bromo-2-chloropyridine-5-carboxylate 3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester Methyl 5-bromo-6-chloropyridine-3-carboxylate ISO 9001：2015 REACH Methyl 5-bromo-6-chl Methyl-5-bromo-6-chloronicotinic acid 5-bromo-3-methoxy-1,2-dihydropyridin-2-one 5-Bromo-6-Chloro methyl nicotinate 3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester (9CI, ACI) 5-bromo-6-chloro-3-Pyridinecarboxylic acid methyl ester (9CI ACI) 78686-77-8 Esters Pyridines Pyridine API intermediates