5-Fluoro-2-hydroxypyridine
- CAS No.
- 51173-05-8
- Chemical Name:
- 5-Fluoro-2-hydroxypyridine
- Synonyms
- 5-Fluoropyridin-2-ol;5-Fluorpyridin-2-ol;5-Fluoro-2-pyridinol;uoro-2-hydroxypyridine;5-fluoro-1H-pyridin-2-one;5-Fluoropyridin-2(1H)-one;3-Fluoro-6-hydroxypyridine;5-FLUORO-2-HYDROXYPYRIDINE;2-HYDROXY-5-FLUOROPYRIDINE;2(1H)-Pyridinone, 5-fluoro-
- CBNumber:
- CB3203611
- Molecular Formula:
- C5H4FNO
- Molecular Weight:
- 113.09
- MDL Number:
- MFCD03092918
- MOL File:
- 51173-05-8.mol
- MSDS File:
- SDS
| Melting point | 150-155°C |
|---|---|
| Boiling point | 251.7±40.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 10.09±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to off-white |
| InChI | 1S/C5H4FNO/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8) |
| InChIKey | KLULSYPVWLJZAO-UHFFFAOYSA-N |
| SMILES | Oc1ccc(F)cn1 |
| CAS DataBase Reference | 51173-05-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335 |
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 |
| target organs | Respiratory system |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29333999 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
5-Fluoro-2-hydroxypyridine price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 753181 | 5-Fluoro-2-hydroxypyridine 97% | 51173-05-8 | 1g | $46.5 | 2023-06-20 | Buy |
| Apolloscientific | PC6957 | 5-Fluoro-2-hydroxypyridine ≥95% | 51173-05-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC6957 | 5-Fluoro-2-hydroxypyridine ≥95% | 51173-05-8 | 5g | $28 | 2026-06-04 | Buy |
| Apolloscientific | PC6957 | 5-Fluoro-2-hydroxypyridine ≥95% | 51173-05-8 | 10g | $48 | 2026-06-04 | Buy |
| Activate Scientific | AS40515 | 5-Fluoro-2-hydroxypyridine 97% | 51173-05-8 | 1g | $25 | 2026-06-04 | Buy |
5-Fluoro-2-hydroxypyridine Chemical Properties, Uses, Production
Uses
5-Fluoro-2-hydroxypyridine is a halogenated compound used in the synthesis of 5-Fluoro-2-hydroxy-3-nitropyridine and 5-halogenated pyrimidine compounds.
Synthesis
5-Fluoro-2-hydroxypyridine is synthesised using 5-fluoro-2-methoxypyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
A total of 4.6 L of toluene solution containing 3-80 was placed in several sealed tubes and treated with 900 ml of 35percent HCl at 145° C. for 2 hr. LC/MS showed no starting material, only 4. The toluene solution was decanted and discarded. The aqueous phase was washed with EtOAc and concentrated down to remove volatiles to afford a brown solid containing the desired fluoro-hydroxypyridine 4-80. [1488] A total of 244 g of this solid was collected and taken to next step as is (it was not completely dry). [1489] Note: We have subsequently run this by decanting the toluene layer first prior to heating to reduce volumes. Same reaction was carried out using HBr (48percent in H2O) at 100° C. for 6 h with similar result to the literature procedure 49percent yield. [1490] Ref: J. Heterocyclic Chem., 10, 779, 1973 (for above Reactions, Including Analytical Data).
References
[1] Patent: US2004/110785, 2004, A1. Location in patent: Page 211
[2] Patent: US2006/142298, 2006, A1. Location in patent: Page/Page column 13
[3] Patent: US2005/209246, 2005, A1. Location in patent: Page/Page column 30; 31
[4] Patent: US2006/142298, 2006, A1. Location in patent: Page/Page column 11; 13
5-Fluoro-2-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 5-Fluoro-2-hydroxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-Fluoro-2-hydroxypyridine
51173-05-8
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 5-Fluoro-2-hydroxypyridine
51173-05-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 5-Fluoro-2-hydroxypyridine
51173-05-8
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 5-Fluoro-2-hydroxypyridine
51173-05-8
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 5-Fluoro-2-hydroxypyridine
51173-05-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Fluoro-2-hydroxypyridine
51173-05-8
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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