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ChemicalBook >> CAS DataBase List >>4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Structure
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one structure
CAS No.
17129-06-5
Chemical Name:
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
Synonyms
(E)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one;AKOS B022234;uoro-3-buten-2-one;ART-CHEM-BB B022234;4-Ethoxy-1,1,1-trifL;2-ethoxyvinyltrifluoroMethylketone;4-ethoxy-1,1,1-trifluoro-3-buten-2-on;4-Ethoxy-1,1,1-trifluorobut-3-en-2-on;4-Ehoxy-1,1,1-trifluoro-3-buten-2-one;4-Ethoxy-1,1,1-trifluoro-3-butan-2-one
CBNumber:
CB3315617
Molecular Formula:
C6H7F3O2
Molecular Weight:
168.11
MDL Number:
MFCD00192131
MOL File:
17129-06-5.mol
MSDS File:
SDS
Last updated:2026-05-28 03:02:42
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4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Properties

Melting point -30℃
Boiling point 51-53 °C/12 mmHg (lit.)
Density 1.18 g/mL at 25 °C (lit.)
refractive index n20/D 1.406(lit.)
Flash point 125 °F
storage temp. 2-8°C
solubility soluble in Chloroform, Methanol
form Liquid
color Colorless to yellow
Sensitive Moisture Sensitive
InChI InChI=1S/C6H7F3O2/c1-2-11-4-3-5(10)6(7,8)9/h3-4H,2H2,1H3
InChIKey YKYIFUROKBDHCY-ONEGZZNKSA-N
SMILES C(F)(F)(F)C(=O)C=COCC
LogP 1.414 (est)
CAS DataBase Reference 17129-06-5(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Health Hazard (GHS08)
GHS02,GHS08
Signal word  Warning
Hazard statements  H226-H351-H412
Precautionary statements  P201-P210-P273-P308+P313
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,F
Risk Statements  10-40
Safety Statements  16-36-36/37
RIDADR  UN 1224 3/PG 3
WGK Germany  3
Hazard Note  Flammable/Harmful
HazardClass  3
PackingGroup  III
HS Code  29147000
Storage Class 3 - Flammable liquids
Hazard Classifications Aquatic Chronic 3
Carc. 2
Flam. Liq. 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 407771 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one contains 0.5% BHT as stabilizer, technical grade 17129-06-5 5g $90.2 2024-03-01 Buy
TRC TRC-E892970-5G 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 17129-06-5 5g $135 2026-06-03 Buy
TRC TRC-E892970-25G 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 17129-06-5 25g $270 2026-06-03 Buy
TRC TRC-E892970-100G 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 17129-06-5 100g $793 2026-06-03 Buy
Apolloscientific PC31704 4-Ethoxy-1,1,1-trifluorobut-3-en-2-one 95%(stabilizedwithTocopherolorBHT) 17129-06-5 1g $21 2026-06-04 Buy
Product number Packaging Price Buy
407771 5g $90.2 Buy
TRC-E892970-5G 5g $135 Buy
TRC-E892970-25G 25g $270 Buy
TRC-E892970-100G 100g $793 Buy
PC31704 1g $21 Buy

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Chemical Properties, Uses, Production

Chemical Properties

light yellow liquid

Uses

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may be used in the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones. It may be used for the synthesis of β-alkyl- or dialkylamino substituted enones bearing a CF3 group.

General Description

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ5-oxaphospholen. It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis.

Synthesis

Perfluoroacetyl fluoride

354-34-7

Ethyl vinyl ether

109-92-2

1-Ethoxy-3-trifluoromethyl-1,3-butadiene

59938-06-6

Example 1 Preparation of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one Ethyl vinyl ether (60 g) and triethylamine (28 g) were placed in an autoclave. The reaction vessel was cooled to 10°C to 15°C with continuous stirring. Trifluoroacetyl fluoride (99 g) was added in batches through an impregnation line of stainless steel cylinders at a temperature of 30°C to 40°C and a pressure of 5 to 10 kg/cm2 . After the addition was completed, the reaction mixture was continued to be stirred for 30 min until the reactor pressure was reduced to 0.25 to 0.5 kg/cm2. Excess trifluoroacetyl fluoride was removed by distillation under reduced pressure, followed by washing the reaction mixture with water. The organic layer was separated and concentrated by decompression to give the title product 4-ethoxy-1,1,1-trifluoro-3-buten-2-one. Yield: 86.2%; purity: 98.2%.

References

[1] Patent: WO2015/11728, 2015, A1. Location in patent: Page/Page column 7

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Preparation Products And Raw materials

Raw materials

Vinyl ether 4,4,4-Trifluoro-3-oxo-butyric acid 1,1,1-Trifluoroacetone Perfluoroacetyl fluoride 2-Butanone, 4-chloro-4-ethoxy-1,1,1-trifluoro-
Trifluoroacetyl chloride Ethyl vinyl ether Trifluoroacetic acid Ethyl formate Triethyl orthoformate

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Preparation Products

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Suppliers

Global Suppliers ( 299)
Supplier Tel Email Country ProdList Advantage
Changzhou Standard Chemicals Ltd. 0519-85607885 13776800733 email@standardschem.com China 118 62
Shanghai Chemart Chemical Technology Co., Ltd. 021-021-50400622 15618790390 info@chemart.cn China 236 58
Changzhou Xiaqing Technological Co., Ltd. 88783621 15961106108 john.chiang@xialichem.com China 143 70
SHANG FLUORO 021-65170832 15601903708 qinba_1@163.com China 401 60
Shandong Jiuyue Biological Technology Co. LT 18853316981 1214127295@qq.com China 294 58
Hangzhou Beishengyuan Biotechnology Co., Ltd 15700194842 15700194842 1289372011@qq.com China 156 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Changzhou Standard Chemicals Ltd. 62
Shanghai Chemart Chemical Technology Co., Ltd. 58
Changzhou Xiaqing Technological Co., Ltd. 70
SHANG FLUORO 60
Shandong Jiuyue Biological Technology Co. LT 58
Hangzhou Beishengyuan Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one pictures 2025-12-25 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
17129-06-5
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
4-Ethoxy-1,1,1-trifluorobut-3-en-2-one pictures 2025-03-29 4-Ethoxy-1,1,1-trifluorobut-3-en-2-one
17129-06-5
 $750.00 98 5000 Kg R&D Scientific Inc.
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one pictures 2019-07-06 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
17129-06-5
 $1.00 1kg 99% Career Henan Chemical Co

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Spectrum

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one(17129-06-5)1HNMR4-Ethoxy-1,1,1-trifluoro-3-buten-2-one(17129-06-5)IR4-Ethoxy-1,1,1-trifluoro-3-buten-2-one(17129-06-5)Raman

17129-06-5 (4-Ethoxy-1,1,1-trifluoro-3-buten-2-one) Related Search:

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4-Ethoxy-1,1,1-trifluoro-3-buten-2-one, 94%, stab. 4-Ethoxy-1,1,1-Trifluoro-3-Buten-2-One, Stab. 2-ethoxyvinyltrifluoroMethylketone (2-Ethoxyvinyl) trifluoromethyl ketone, 1-Ethoxy-3-oxo-4,4,4-trifluorobut-1-ene 4-ETHOXY-1,1,1-TRIFLUORO-3-BUTEN-2-ONE, TECH. 4-ethoxy-1,1,1-trifluoro-3-buten-2-on (3E)-4-Ethoxy-1,1,1-trifluorobut-3-en-2-one 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one contains 0.5% BHT as stabilizer, technical grade 4-Ethoxy-1,1,1-trifluoro-3-butan-2-one 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one, stabilized 4-ETHOXY-1,1,1-TRIFLUORO-3-BUTEN-2-ONE 4-ETHOXY-1,1,1-TRIFLUORO-BUT-3-EN-2-ONE AKOS B022234 ART-CHEM-BB B022234 4-Ethoxy-1,1,1-trifL uoro-3-buten-2-one 3-Buten-2-one, 4-ethoxy-1,1,1-trifluoro- TIANFU-CHEM - 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 4-Ethoxy-1,1,1-trifluorobut-3-en-2-on 4-Ehoxy-1,1,1-trifluoro-3-buten-2-one (E)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one 17129-06-5 59983-06-6 C2H5OCHCHCOCF3 Organic Building Blocks Ketones C3 to C6 Carbonyl Compounds Building Blocks C3 to C6 Carbonyl Compounds Ketones Alcohol& Phenol& Ethers