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ChemicalBook >> CAS DataBase List >>N,N,N',N'-Tetramethylazodicarboxamide

N,N,N',N'-Tetramethylazodicarboxamide

N,N,N',N'-Tetramethylazodicarboxamide Structure
N,N,N',N'-Tetramethylazodicarboxamide structure
CAS No.
10465-78-8
Chemical Name:
N,N,N',N'-Tetramethylazodicarboxamide
Synonyms
TMAD;DIAMIDE;Tetramethylazodicarboxamide;(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea;(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea;(E)-N1,N1,N2,N2-tetramethyldiazene-1,2-dicarboxamide;1,1'-AZOBIS(N,N-DIMETHYLFORMAMIDE);3-(Dimethylcarbamoylimino)-1,1-dimethylurea;N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide;Nsc143013
CBNumber:
CB3340747
Molecular Formula:
C6H12N4O2
Molecular Weight:
172.19
MDL Number:
MFCD00008318
MOL File:
10465-78-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:08:17
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N,N,N',N'-Tetramethylazodicarboxamide Properties

Melting point 112 °C
Boiling point 220.4±23.0 °C(Predicted)
Density 1.13±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility soluble in Methanol
form crystalline
pka -0+-.0.70(Predicted)
color yellow
Water Solubility water: 19.60-21.00mg/mL, clear to slightly hazy, orange
BRN 1910409
InChI InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChIKey VLSDXINSOMDCBK-BQYQJAHWSA-N
SMILES C(=O)(/N=N/C(=O)N(C)C)N(C)C
CAS DataBase Reference 10465-78-8(CAS DataBase Reference)
FDA UNII 86EQC90W32
UNSPSC Code 12352102
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
RTECS  LQ1041000
F  4.10
HS Code  29270000
Storage Class 11 - Combustible Solids
REACH Registrations Active

N,N,N',N'-Tetramethylazodicarboxamide price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D3648 Diamide 10465-78-8 1g $156 2026-04-30 Buy
Sigma-Aldrich D3648 Diamide 10465-78-8 5g $690 2026-04-30 Buy
TCI Chemical A1458 1,1'-Azobis(N,N-dimethylformamide) >97.0%(T) 10465-78-8 1g $23 2026-04-30 Buy
TCI Chemical A1458 1,1'-Azobis(N,N-dimethylformamide) >97.0%(T) 10465-78-8 5g $84 2026-04-30 Buy
Biosynth FT45870 TMAD 10465-78-8 0.025kg $319 2026-06-04 Buy
Product number Packaging Price Buy
D3648 1g $156 Buy
D3648 5g $690 Buy
A1458 1g $23 Buy
A1458 5g $84 Buy
FT45870 0.025kg $319 Buy

N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties,Uses,Production

Description

N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.

References

N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133

Chemical Properties

Yellow crystals

Uses

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Definition

ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007

N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials

Raw materials

Silver oxide Triethylamine Dimethylcarbamoyl chloride Dichloromethane HYDRAZINE

Preparation Products

1-amino-9,10-dihydro-9,10-dioxoanthracene-2-carbaldehyde 2-[(1-amino-9,10-dihydro-9,10-dioxo-2-anthryl)methylene]hydrazone 1H-Indazole-3-diazonium, 6-chloro-

N,N,N',N'-Tetramethylazodicarboxamide Suppliers

Global( 209)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
Suzhou BEC Biological Technology Co., Ltd +86-512-68095917 17712685869 sales@bek.com.cn China 142 59
SuZhou Jonathan New Material Technology Co., Ltd. 0512-68312916,63926215 18912725070;18013709950 jon@jonnmt.com China 109 58
Changzhou Jianuokang Pharmaceutical Co., Ltd. 0519-85202684; 13775120798 jnkpharmtech@163.com China 284 55
Shanghai Ruiyi Pharmaceutical Technology Co., Ltd 021-54711706 sales5@ruiyitech.com China 224 58
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 9992 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 75
Suzhou BEC Biological Technology Co., Ltd 59
SuZhou Jonathan New Material Technology Co., Ltd. 58
Changzhou Jianuokang Pharmaceutical Co., Ltd. 55
Shanghai Ruiyi Pharmaceutical Technology Co., Ltd 58
Accela ChemBio Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81

Related articles

View Lastest Price from N,N,N',N'-Tetramethylazodicarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N,N',N'-Tetramethylazodicarboxamide pictures 2026-06-30 N,N,N',N'-Tetramethylazodicarboxamide
10465-78-8
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Diamide pictures 2026-05-11 Diamide
10465-78-8
 $50.00-128.00 99.88% 10g TargetMol Chemicals Inc.
N,N,N',N'-Tetramethylazodicarboxamide pictures 2019-07-06 N,N,N',N'-Tetramethylazodicarboxamide
10465-78-8
 $1.00 1KG 99% 1ton Career Henan Chemical Co
  • Diamide pictures
  • Diamide
    10465-78-8
  • $50.00-128.00
  • 99.88%
  • TargetMol Chemicals Inc.

N,N,N',N'-Tetramethylazodicarboxamide Spectrum

N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)MSN,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)1HNMRN,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)IR1N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)IR2N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)Raman

10465-78-8(N,N,N',N'-Tetramethylazodicarboxamide)Related Search:

Di-tert-Butyl azodicarboxylate Polyacrylamide Metformin 1,1'-(Azodicarbonyl)-dipiperidine Azodicarbonamide
Phthalamide N,N-Dimethylformamide N,N,N',N'-Tetraphenylbenzidine 1,8-Bis(dimethylamino)naphthalene Pentamethyldiethylenetriamine
Diethyl azodicarboxylate Dibenzyl azodicarboxylate Diisopropyl azodicarboxylate N,N,N',N'-Tetramethyldiaminomethane Azodicarboxylic bismorpholide
1,1-Dimethylurea Formamide N,N,N',N'-Tetramethylazodicarboxamide

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AZODICARBOXYLIC ACID BIS[DIMETHYLAMIDE] DIAZINE-DICARBOXYLIC ACID BIS[N,N-DIMETHYLAMIDE] 1,1'-AZOBIS(N,N'-DIMETHYLFORMAMIDE) N,N,N',N'-TETRAMETHYLAZODICARBAMIDE 1,1’-azobis(n,n-dimethyl-formamid n,n,n’,n’-tetramethylazoformamide Diamide N,N,N',N'-Tetramethylazodicarboxamide Azodicarboxylic acid bis(dimethylamide), diamide N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide TMAD N,N,N',N'-tetramethylazodicarboxamide 1,1'-Azobis(N,N-dimethylformamide)≥ 98%(Titration) N,N,N',N'-Tetramethylazobisformamide Nsc143013 N,N,N',N'-Tetramethylazodicarboxamide(TMAD) Diamide ,98% 1-[(diMethylcarbaMoyl)iMino]-3,3-diMethylurea tetramethyl-diazenedicarboxamid tetramethyldiazenedicarboxamide 1,1-Azobis(N,N-dimethylforamide) 3-(N,N-dimethylcarbamoylimido)-1,1-dimethylurea Diamide 1,1-Azobis(N,N-dimethylformamide) blowing (and foaming) agent AC Diazenedicarboxamide, tetramethyl- Azobis(N,N-dimethylformamide) N,N,N',N'-Tetramethyldiazene-1,2-dicarboxamide N,N,N',N'-Tetramethyldiazenedicarboxamide 1,1'-Azobis(N,N-dimethylformamide),98% Tetramethylazodicarboxamide(TMAD) 1,1μ-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide), Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide Azodicarboxylic acid bis(dimethylamide), diamide, Diamide, Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide 1,1′-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide) Diazenedicarboxylic acid bis(N,N-dimethylamide) Formamide, 1,1'-azobis[N,N-dimethyl- 1,1'-Azobis(N,N-dimethylformamide) > Diamide, 98%, for synthesis 1,2-Diazenedicarboxamide, N1,N1,N2,N2-tetramethyl- N,N,N',N'-Tetramethylazodicarboxamide ISO 9001：2015 REACH TIANFU-CHEM CAS:10465-78-8 N,N,N',N'-Tetramethylazodicarboxamide N,N,N',N'-Tetramethylazodicarboxamide TMADN,N,N',N'-tetramethylazodicarboxamide N,N,N’,N’-Tetramethylazodicarboxamide(TMAD) Diamide, 10 mM in DMSO N1,N1,N2,N2-Tetramethyl-1,2-diazenedicarboxamide - [D71729] N,N,N',N'-Tetramethylazodicarboxamide 1,1'-AZOBIS(N,N-DIMETHYLFORMAMIDE) (E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea (3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea (E)-N1,N1,N2,N2-tetramethyldiazene-1,2-dicarboxamide 3-(Dimethylcarbamoylimino)-1,1-dimethylurea DIAMIDE Tetramethylazodicarboxamide TMAD 10465-78-8 CH32NCONNCONCH32 Amides BioChemical Building Blocks Biochemicals and Reagents