Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-Chlorobenzhydrazide

4-Chlorobenzhydrazide

4-Chlorobenzhydrazide Structure
4-Chlorobenzhydrazide structure
CAS No.
536-40-3
Chemical Name:
4-Chlorobenzhydrazide
Synonyms
4-CHLOROBENZOHYDRAZIDE;4-CHLOROBENZOIC ACID HYDRAZIDE;INHd 15;NSC 54990;AKOS 92880;AKOS BBS-00004505;TIMTEC-BB SBB003853;p-Chlorobenzhydrazide;4-Chlorobenzhydrazide;P-CHLOROBENZOHYDRAZIDE
CBNumber:
CB3419164
Molecular Formula:
C7H7ClN2O
Molecular Weight:
170.6
MDL Number:
MFCD00007603
MOL File:
536-40-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:02
Request For Quotation

4-Chlorobenzhydrazide Properties

Melting point 162-165 °C (lit.)
Boiling point 170.60°C
Density 1.323
refractive index 1.5618 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility soluble in Methanol
form powder to crystal
pka 12.09±0.10(Predicted)
color White to Almost white
BRN 511154
InChI InChI=1S/C7H7ClN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)
InChIKey PKBGHORNUFQAAW-UHFFFAOYSA-N
SMILES C(NN)(=O)C1=CC=C(Cl)C=C1
CAS DataBase Reference 536-40-3(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29280000
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

4-Chlorobenzhydrazide price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 259616 4-Chlorobenzhydrazide 98% 536-40-3 5g $33.8 2026-04-30 Buy
TCI Chemical C2060 4-Chlorobenzohydrazide >98.0%(GC)(T) 536-40-3 5g $47 2026-04-30 Buy
TCI Chemical C2060 4-Chlorobenzohydrazide >98.0%(GC)(T) 536-40-3 25g $186 2026-04-30 Buy
Usbiological 269291 4-Chlorobenzhydrazide Asreported 536-40-3 10g $207 2026-06-03 Buy
Usbiological 269291 4-Chlorobenzhydrazide Asreported 536-40-3 25g $303 2026-06-03 Buy
Product number Packaging Price Buy
259616 5g $33.8 Buy
C2060 5g $47 Buy
C2060 25g $186 Buy
269291 10g $207 Buy
269291 25g $303 Buy

4-Chlorobenzhydrazide Chemical Properties, Uses, Production

Chemical Properties

white to light beige crystals, flakes or

Uses

4-Chlorobenzhydrazide has been used in preparation of:

  • rod-shaped mesogenic hydrazide derivatives via Schotten-Baumann reaction with 4-n-alkoxybenzoyl chloride
  • 4-methoxybenzaldehyde-4-chlorophenyl-1-carbonyl hydrazone
  • 4-hydroxybenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
  • 2-nitrobenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
  • benzaldehyde-4-chlorophenyl-1-carbonylhydrazone

General Description

Effect of acidic catalyst on the reaction of 4-chlorobenzhydrazide and β-naphthol in water has been investigated.

Synthesis

ETHYL 4-CHLOROBENZOATE

7335-27-5

4-CHLOROBENZHYDRAZIDE

536-40-3

General procedure for the synthesis of 4-chlorobenzoyl hydrazine from ethyl p-chlorobenzoate: hydrazine was synthesized conventionally using the one-pot method (30-58% yield). 10 mmol of ethyl p-chlorobenzoate was dissolved in 20 mL of ethanol. 2 mL of 3N sulfuric acid was added to the solution and the reaction mixture was refluxed for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with solid NaHCO3 and filtered to remove excess NaHCO3. To the neutralized reaction mixture, 1.5 mL (3 mmol) of hydrazine monohydrate was added and refluxing was continued for 3-6 h to ensure complete reaction. The ethanol and unreacted hydrazine were evaporated to 1/3 of the original volume by distillation.The reaction mixture was cooled to room temperature, the product was collected by filtration and recrystallized from methanol to give pure 4-chlorobenzhydrazide crystals (see Supporting Information for specific data).

Purification Methods

Crystallise it from H2O. [Beilstein 9 III 1368.]

References

[1] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2755 - 2767
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[3] Patent: CN106008390, 2016, A. Location in patent: Paragraph 0015
[4] Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1101 - 1109
[5] Oriental Journal of Chemistry, 2017, vol. 33, # 2, p. 971 - 978

4-Chlorobenzhydrazide Preparation Products And Raw materials

Raw materials

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate 4-Chlorobenzoic acid Methyl 4-chlorobenzoate Ethyl 4-chlorobenzoate 4-Chlorobenzamide
Hydrazine hydrate Ethanol Water

1of2

Preparation Products

Acemetacin 4-Benzyl-5-(4-chloro-phenyl)-4H-[1,2,4]triazole-3-thiol 4H-1,2,4-Triazole-4-acetic acid, 3-(4-chlorophenyl)-1,5-dihydro-5-oxo- Ethyl 3-[2-(4-chlorobenzoyl)hydrazino]-3-iminopropanoate 2-(Chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
2-(4-chlorophenyl)-5-Methyl-1,3,4-oxadiazole

1of2

4-Chlorobenzhydrazide Suppliers

Global Suppliers ( 221)
Supplier Tel Email Country ProdList Advantage
Chongqing AoShe Biological Chemical Co., Ltd. 023-63225655 13320248848 2366581735@qq.com China 501 55
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Chongqing AoShe Biological Chemical Co., Ltd. 55
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 4-Chlorobenzhydrazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chlorobenzhydrazide pictures 2026-09-11 4-Chlorobenzhydrazide
536-40-3
 $220.00 1Kg 98% 500g;1kg;5kg;10kg;100kg; Zjartspharm Co., Ltd
4-CHLOROBENZHYDRAZIDE pictures 2019-07-06 4-CHLOROBENZHYDRAZIDE
536-40-3
 $1.00 1G 99% 100KG Career Henan Chemical Co

4-Chlorobenzhydrazide Spectrum

4-CHLOROBENZHYDRAZIDE(536-40-3)1HNMR4-CHLOROBENZHYDRAZIDE(536-40-3)IR14-CHLOROBENZHYDRAZIDE(536-40-3)IR24-CHLOROBENZHYDRAZIDE(536-40-3)Raman

536-40-3 (4-Chlorobenzhydrazide) Related Search:

5-Bromo-2-chlorobenzhydrazide 3-Chlorobenzhydrazide 4-Chlorobenzhydrazide Benzoyl hydrazine Formylhydrazine
Indapamide o-Chlorobenzhydrazide,2-CHLOROBENZHYDRAZIDE,2-Chlorobenzhydrazide,98% 2,4-Dichlorobenzhydrazide 3,4-Dichlorobenzene-1-carbohydrazide (2-Amino-5-chlorobenzoyl)hydrazide
2-Bromo-4-chlorobenzhydrazide 4-Bromo-3-chlorobenzhydrazide N'-Phenyl-p-chlorobenzhydrazide 4-Chloro-3-nitrobenzhydrazide 3-Bromo-4-chlorobenzhydrazide
4-Bromo-2-chlorobenzhydrazide 2-Bromo-5-chlorobenzhydrazide N'1-(4-Chlorobenzoyl)-2-chloro-5-nitrobenzene-1-carbohydrazide

1of4

4-Chlorobenzoylhydrazine 4-Chlorobenzoic Hydrazide 4-Chlorobenzenecarboxylic acid hydrazide INHd 15 NSC 54990 4-Chlorobenzohydrazide, 4-Chlorobenzenecarbohydrazide 4-Chlorobenzhydrazide 98% 4-CHLOROBENZOIC HYDRAZIDE 4-CHLOROBENZOYLHYDRAZINE 4-CHLOROBENZENE-1-CARBOHYDRAZIDE TIMTEC-BB SBB003853 P-CHLOROBENZOHYDRAZIDE (P-CHLOROBENZOYL)HYDRAZINE AKOS 92880 AKOS BBS-00004505 LABOTEST-BB LT00053515 4-Chlorobenzoyl hydrazide Benzoic acid, 4-chloro-, hydrazide Benzoic acid, p-chloro-, hydrazide p-Chlorobenzhydrazide p-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzenecarbohydrazide 4-Chlorobenzoic hydrazide,98% 4-Chlorobenzhydrazide, 98+% 4-CHLOROBENZOIC HYDRAZOLE 4-Chlorobenzohydrazide > 4-CHLOROBENZOIC ACID HYDRAZIDE 4-CHLOROBENZOHYDRAZIDE 4-Chlorobenzhydrazide 536-40-3 578-02-0 C7H7ClN2O Carbonyl Compounds Building Blocks Organic Building Blocks Hydrazides blocks Carboxes Carbonyl Compounds Hydrazides Organic Building Blocks Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes Chlorine Compounds