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4-CHLOROBENZHYDRAZIDE

4-CHLOROBENZHYDRAZIDE structure

CAS No.: 536-40-3

Chemical Name:: 4-CHLOROBENZHYDRAZIDE

Synonyms: 4-CHLOROBENZOHYDRAZIDE;4-CHLOROBENZOIC ACID HYDRAZIDE;INHd 15;NSC 54990;AKOS 92880;AKOS BBS-00004505;TIMTEC-BB SBB003853;4-CHLOROBENZHYDRAZIDE;p-Chlorobenzhydrazide;P-CHLOROBENZOHYDRAZIDE

CBNumber:: CB3419164

Molecular Formula:: C7H7ClN2O

Molecular Weight:: 170.6

MDL Number:: MFCD00007603

MOL File:: 536-40-3.mol

MSDS File:: SDS

Last updated:2026-05-28 06:31:01

Product description	Number	Pack Size	Price
4-Chlorobenzhydrazide 98%	259616	5g	$33.8
4-Chlorobenzohydrazide >98.0%(GC)(T)	C2060	5g	$47
4-Chlorobenzohydrazide >98.0%(GC)(T)	C2060	25g	$186
4-Chlorobenzhydrazide	056675	5.00g	$39
4-Chlorobenzhydrazide 98%	C45695	1g	$13
More product size

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4-CHLOROBENZHYDRAZIDE Properties

Melting point	162-165 °C (lit.)
Boiling point	170.60°C
Density	1.323
refractive index	1.5618 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
form	powder to crystal
pka	12.09±0.10(Predicted)
color	White to Almost white
BRN	511154
InChI	InChI=1S/C7H7ClN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)
InChIKey	PKBGHORNUFQAAW-UHFFFAOYSA-N
SMILES	C(NN)(=O)C1=CC=C(Cl)C=C1
CAS DataBase Reference	536-40-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29280000

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

4-CHLOROBENZHYDRAZIDE price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	259616	4-Chlorobenzhydrazide 98%	536-40-3	5g	$33.8	2026-04-30	Buy
TCI Chemical	C2060	4-Chlorobenzohydrazide >98.0%(GC)(T)	536-40-3	5g	$47	2026-04-30	Buy
TCI Chemical	C2060	4-Chlorobenzohydrazide >98.0%(GC)(T)	536-40-3	25g	$186	2026-04-30	Buy
Matrix Scientific	056675	4-Chlorobenzhydrazide	536-40-3	5.00g	$39	2026-05-18	Buy
Synthonix	C45695	4-Chlorobenzhydrazide 98%	536-40-3	1g	$13	2026-05-06	Buy

Product number	Packaging	Price	Buy
259616	5g	$33.8	Buy
C2060	5g	$47	Buy
C2060	25g	$186	Buy
056675	5.00g	$39	Buy
C45695	1g	$13	Buy

4-CHLOROBENZHYDRAZIDE Chemical Properties,Uses,Production

Chemical Properties

white to light beige crystals, flakes or

Uses

4-Chlorobenzhydrazide has been used in preparation of:

rod-shaped mesogenic hydrazide derivatives via Schotten-Baumann reaction with 4-n-alkoxybenzoyl chloride
4-methoxybenzaldehyde-4-chlorophenyl-1-carbonyl hydrazone
4-hydroxybenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
2-nitrobenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
benzaldehyde-4-chlorophenyl-1-carbonylhydrazone

General Description

Effect of acidic catalyst on the reaction of 4-chlorobenzhydrazide and β-naphthol in water has been investigated.

Synthesis

7335-27-5

536-40-3

General procedure for the synthesis of 4-chlorobenzoyl hydrazine from ethyl p-chlorobenzoate: hydrazine was synthesized conventionally using the one-pot method (30-58% yield). 10 mmol of ethyl p-chlorobenzoate was dissolved in 20 mL of ethanol. 2 mL of 3N sulfuric acid was added to the solution and the reaction mixture was refluxed for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with solid NaHCO3 and filtered to remove excess NaHCO3. To the neutralized reaction mixture, 1.5 mL (3 mmol) of hydrazine monohydrate was added and refluxing was continued for 3-6 h to ensure complete reaction. The ethanol and unreacted hydrazine were evaporated to 1/3 of the original volume by distillation.The reaction mixture was cooled to room temperature, the product was collected by filtration and recrystallized from methanol to give pure 4-chlorobenzhydrazide crystals (see Supporting Information for specific data).

Purification Methods

Crystallise it from H2O. [Beilstein 9 III 1368.]

References

[1] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2755 - 2767
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[3] Patent: CN106008390, 2016, A. Location in patent: Paragraph 0015
[4] Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1101 - 1109
[5] Oriental Journal of Chemistry, 2017, vol. 33, # 2, p. 971 - 978

4-CHLOROBENZHYDRAZIDE Preparation Products And Raw materials

Raw materials

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate 4-Chlorobenzoic acid METHYL 4-CHLOROBENZOATE ETHYL 4-CHLOROBENZOATE 4-Chlorobenzamide

Hydrazine hydrate Ethanol Water

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Preparation Products

Acemetacin 4-BENZYL-5-(4-CHLORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL 4H-1,2,4-Triazole-4-acetic acid, 3-(4-chlorophenyl)-1,5-dihydro-5-oxo- ETHYL 3-[2-(4-CHLOROBENZOYL)HYDRAZINO]-3-IMINOPROPANOATE 2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE

2-(4-chlorophenyl)-5-Methyl-1,3,4-oxadiazole

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4-CHLOROBENZHYDRAZIDE Suppliers

Global( 219)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	938	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Changzhou Ditong Chemical Co.,Ltd	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Jinan Liheng Biotechnology Co., Ltd.	58
Fuxin Pharmaceutical	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from 4-CHLOROBENZHYDRAZIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-27	4-Chlorobenzhydrazide 536-40-3	$220.00	1Kg	98%	500g;1kg;5kg;10kg;100kg;	Zjartspharm Co., Ltd
	2019-07-06	4-CHLOROBENZHYDRAZIDE 536-40-3	$1.00	1G	99%	100KG	Career Henan Chemical Co

4-Chlorobenzhydrazide
536-40-3
$220.00
98%
Zjartspharm Co., Ltd

4-CHLOROBENZHYDRAZIDE
536-40-3
$1.00
99%
Career Henan Chemical Co

4-CHLOROBENZHYDRAZIDE Spectrum

4-CHLOROBENZHYDRAZIDE(536-40-3)¹HNMR 4-CHLOROBENZHYDRAZIDE(536-40-3)IR1 4-CHLOROBENZHYDRAZIDE(536-40-3)IR2 4-CHLOROBENZHYDRAZIDE(536-40-3)Raman

536-40-3(4-CHLOROBENZHYDRAZIDE)Related Search:

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(2-AMINO-5-CHLOROBENZOYL)HYDRAZIDE 3-Chlorobenzhydrazide, 98+%,3-CHLOROBENZHYDRAZIDE Formylhydrazine Benzoyl hydrazine 5-BROMO-2-CHLOROBENZHYDRAZIDE

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4-Chlorobenzoylhydrazine 4-Chlorobenzoic Hydrazide 4-Chlorobenzenecarboxylic acid hydrazide INHd 15 NSC 54990 4-Chlorobenzohydrazide, 4-Chlorobenzenecarbohydrazide 4-Chlorobenzhydrazide 98% 4-CHLOROBENZOIC HYDRAZIDE 4-CHLOROBENZOYLHYDRAZINE 4-CHLOROBENZENE-1-CARBOHYDRAZIDE 4-CHLOROBENZHYDRAZIDE TIMTEC-BB SBB003853 P-CHLOROBENZOHYDRAZIDE (P-CHLOROBENZOYL)HYDRAZINE AKOS 92880 AKOS BBS-00004505 LABOTEST-BB LT00053515 4-Chlorobenzoyl hydrazide Benzoic acid, 4-chloro-, hydrazide Benzoic acid, p-chloro-, hydrazide p-Chlorobenzhydrazide p-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzenecarbohydrazide 4-Chlorobenzoic hydrazide,98% 4-Chlorobenzhydrazide, 98+% 4-CHLOROBENZOIC HYDRAZOLE 4-Chlorobenzohydrazide > 4-CHLOROBENZOIC ACID HYDRAZIDE 4-CHLOROBENZOHYDRAZIDE 536-40-3 578-02-0 C7H7ClN2O Carbonyl Compounds Building Blocks Organic Building Blocks Hydrazides blocks Carboxes Carbonyl Compounds Hydrazides Organic Building Blocks Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes Chlorine Compounds