5-Bromo-3-cyano-2-hydroxypyridine
- CAS No.
- 405224-22-8
- Chemical Name:
- 5-Bromo-3-cyano-2-hydroxypyridine
- Synonyms
- 5-bromo-2-hydroxynicotino...;5-Bromo-3-cyano-2(1H)-pyridinone;5-BROMO-2-HYDROXYNICOTINONITRILE;5-BROMO-3-CAYNO-2(1H)-PYRIDINONE;5-BROMO-3-CYANO-2-HYDROXYPYRIDINE;5-Bromo-2-hydroxynicotinonitrile98%;5-Bromo-2-hydroxynicotinonitrile 98%;5-Bromo-3-cyano-2-hydroxypyridine 98%;5-bromo-2-hydroxypyridine-3-carbonitrile;5-BROMO-2-HYDROXY-3-PYRIDINECARBONITRILE
- CBNumber:
- CB3429637
- Molecular Formula:
- C6H3BrN2O
- Molecular Weight:
- 199
- MDL Number:
- MFCD07363806
- MOL File:
- 405224-22-8.mol
- MSDS File:
- SDS
| Melting point | 219-221 |
|---|---|
| Boiling point | 292.1±40.0 °C(Predicted) |
| Density | 1.84±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| pka | 6.87±0.10(Predicted) |
| color | Beige |
| InChI | InChI=1S/C6H3BrN2O/c7-5-1-4(2-8)6(10)9-3-5/h1,3H,(H,9,10) |
| InChIKey | SWTLLSLCDHXNIU-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(Br)C=C1C#N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant/Keep Cold |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
5-Bromo-3-cyano-2-hydroxypyridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 263832 | 5-Bromo-3-cyano-2(1H)-pyridinone Asreported | 405224-22-8 | 500mg | $375 | 2026-06-03 | Buy |
| Usbiological | 263832 | 5-Bromo-3-cyano-2(1H)-pyridinone Asreported | 405224-22-8 | 1g | $542 | 2026-06-03 | Buy |
| Usbiological | 263832 | 5-Bromo-3-cyano-2(1H)-pyridinone Asreported | 405224-22-8 | 2g | $776 | 2026-06-03 | Buy |
| Usbiological | 263832 | 5-Bromo-3-cyano-2(1H)-pyridinone Asreported | 405224-22-8 | 5g | $1055 | 2026-06-03 | Buy |
| Usbiological | 263832 | 5-Bromo-3-cyano-2(1H)-pyridinone Asreported | 405224-22-8 | 10g | $1572 | 2026-06-03 | Buy |
5-Bromo-3-cyano-2-hydroxypyridine Chemical Properties, Uses, Production
Synthesis
20577-27-9
405224-22-8
General procedure for the synthesis of 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-oxo-1,2-dihydropyridine-3-carbonitrile: 2-oxo-1,2-dihydropyridine-3-carbonitrile (50 mg, 0.42 mmol) and sodium acetate (69 mg, 0.84 mmol) were dissolved in 5 mL of glacial acetic acid at room temperature, and stirred until complete dissolution. Subsequently, bromine (21.5 μL, 0.42 mmol) was slowly added to the solution and the reaction lasted for 2 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the acetic acid. The crude product was purified by column chromatography (using ethyl acetate as eluent) to afford 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile (69 mg, 75% yield) as a yellow solid. Melting point: 216~217°C. 1H NMR (400MHz, CD3COCD3): δ11.70 (s, 1H), 8.22 (d, J = 2.8Hz, 1H), 8.05 (d, J = 2.8Hz, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 9, p. 1577 - 1580
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5578 - 5585
[5] Patent: US2004/19052, 2004, A1. Location in patent: Page/Page column 17
5-Bromo-3-cyano-2-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
View Latest Price from 5-Bromo-3-cyano-2-hydroxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-Bromo-2-hydroxynicotinonitrile
405224-22-8
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2025-06-25 | 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-13 | 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Bromo-2-hydroxynicotinonitrile
405224-22-8
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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