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4-Methoxy-3-hydroxyacetophenone

4-Methoxy-3-hydroxyacetophenone structure

CAS No.: 6100-74-9

Chemical Name:: 4-Methoxy-3-hydroxyacetophenone

Synonyms: 1-(3-hydroxy-4-Methoxyphenyl)ethan-1-one;Acetoisovanillone;Ethanone, 1-(3-hydroxy-4-Methoxyphenyl)-;3-HYDROXY-4-METHOXYACETOPHENONE;Isoacetovanillone;NSC 30050;ACETOISOVANILLONE(SH);Diosmin EP Impurity A;Dioxamine EP Impurity A;5-Acetyl-2-methoxyphenol

CBNumber:: CB3435814

Molecular Formula:: C9H10O3

Molecular Weight:: 166.17

MDL Number:: MFCD00182975

MOL File:: 6100-74-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:03

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4-Methoxy-3-hydroxyacetophenone Properties

Melting point	88-92 °C
Boiling point	329.9±27.0 °C(Predicted)
Density	1.158
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.15±0.10(Predicted)
color	Off-White to Yellow
Stability	Stable. Incompatible with strong oxidizing agents.
InChI	InChI=1S/C9H10O3/c1-6(10)7-3-4-9(12-2)8(11)5-7/h3-5,11H,1-2H3
InChIKey	YLTGFGDODHXMFB-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(OC)C(O)=C1)C
LogP	1.373 (est)
FDA UNII	286G943O33
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

WGK Germany

HS Code

2914390090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	0
2		0

4-Methoxy-3-hydroxyacetophenone price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	679704	3′-Hydroxy-4′-methoxyacetophenone 97%	6100-74-9	1g	$107	2026-04-30	Buy
Sigma-Aldrich	679704	3′-Hydroxy-4′-methoxyacetophenone 97%	6100-74-9	5g	$206	2026-04-30	Buy
TCI Chemical	H1946	1-(3-Hydroxy-4-methoxyphenyl)ethan-1-one min. 98.0 %	6100-74-9	1G	$43	2026-04-30	Buy
TCI Chemical	H1946	1-(3-Hydroxy-4-methoxyphenyl)ethan-1-one min. 98.0 %	6100-74-9	5G	$129	2026-04-30	Buy
Cayman Chemical	36801	3-Hydroxy-4-methoxyacetophenone ≥95%	6100-74-9	1g	$37	2026-04-30	Buy

Product number	Packaging	Price	Buy
679704	1g	$107	Buy
679704	5g	$206	Buy
H1946	1G	$43	Buy
H1946	5G	$129	Buy
36801	1g	$37	Buy

4-Methoxy-3-hydroxyacetophenone Chemical Properties, Uses, Production

Chemical Properties

solid

Uses

Isoacetovanillone is a volatile compound isolated from oak wood. Also a byproduct in the production of Acetovanillone.

Uses

Isoacetovanillone (Diosmin EP Impurity A) is a volatile compound isolated from oak wood. Also a byproduct in the production of Acetovanillone.

Definition

ChEBI: Isoacetovanillone is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.

Preparation

Preparation by saponification of 3-acetoxy-4-methoxy-acetophenone (90%) (59%).

Synthesis Reference(s)

Synthetic Communications, 18, p. 1379, 1988 DOI: 10.1080/00397918808078806

Synthesis

1-(4-Methoxy-3-propan-2-yloxyphenyl)ethanone

88114-44-7

6100-74-9

General procedure for the synthesis of 4-methoxy-3-hydroxyacetophenone from 3'-hydroxy-4'-methoxyacetophenone (12): ketone 8 (250 mg, 1.20 mmol) was dissolved in anhydrous CH2Cl2 (3 mL), AlCl3 (208 mg, 1.56 mmol) was added, and the reaction was stirred for 24 h at 18 °C and under nitrogen protection. After completion of the reaction, the mixture was partitioned between water (10 mL) and CH2Cl2 (10 mL). The aqueous phase was extracted once with CH2Cl2 (10 mL), the organic phases were combined, dried with MgSO4, filtered and concentrated under reduced pressure. The light yellow oil obtained was purified by fast chromatography (eluent: ethyl acetate/hexane, 1:4 v/v) to give a white solid 4-methoxy-3-hydroxyacetophenone 124 (172 mg, 86% yield) with a melting point of 88.6-90.5 °C (literature value: 92-93 °C) and a TLC (silica gel plate, unfolding agent: ethyl acetate/hexane, 1:1 v/v) Rf value was 0.4. 1H NMR (300MHz, CDCl3) δ: 7.53-7.56 (m, 2H), 6.89 (d, J=7.5Hz, 1H), 5.73 (br s, 1H), 3.96 (s, 3H), 2.54 (s, 3H).

References

[1] Patent: WO2008/124878, 2008, A1. Location in patent: Page/Page column 38

4-Methoxy-3-hydroxyacetophenone synthesis

Synthesis of 4-Methoxy-3-hydroxyacetophenone from 3,4-Dihydroxyacetophenone and Iodomethane

4-Methoxy-3-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

1-(4-Methoxy-3-propan-2-yloxyphenyl)ethanone 2-Methoxyphenyl acetate 3-Isopropoxy-4-methoxy-benzaldehyde 3,4-Dihydroxyacetophenone 3,4-Dimethoxyacetophenone

Aluminum chloride Iodomethane Acetovanillone Vanillin Acetic anhydride

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Preparation Products

4-Methoxy-3-hydroxyacetophenone Suppliers

Global Suppliers ( 190)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai He-H Chemical Technology Co., Ltd	18621911604	987025641@qq.com	China	1233	58
Sci-Sun Technology CO.,Ltd	18252089365	Krain_kerun@163.com	China	2877	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65

Supplier	Advantage
Shanghai He-H Chemical Technology Co., Ltd	58
Sci-Sun Technology CO.,Ltd	58
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
BioBioPha Co., Ltd.	65

View Latest Price from 4-Methoxy-3-hydroxyacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	4-METHOXY-3-HYDROXYACETOPHENONE 6100-74-9	$10.70	10KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-04-22	3-Hydroxy-4-methoxyacetophenone 6100-74-9			97.03%	10g	TargetMol Chemicals Inc.
2026-04-22	3-Hydroxy-4-methoxyacetophenone 6100-74-9			97.03%	10g	TargetMol Chemicals Inc.

4-METHOXY-3-HYDROXYACETOPHENONE
6100-74-9
$10.70
99%
Hebei Chuanghai Biotechnology Co,.LTD

3-Hydroxy-4-methoxyacetophenone
6100-74-9
$0.00
97.03%
TargetMol Chemicals Inc.

3-Hydroxy-4-methoxyacetophenone
6100-74-9
$0.00
97.03%
TargetMol Chemicals Inc.

4-Methoxy-3-hydroxyacetophenone Spectrum

4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)MS 4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)¹HNMR 4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)IR1 4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)IR2

6100-74-9 (4-Methoxy-3-hydroxyacetophenone) Related Search:

3,4-Methylenedioxyacetophenone 3′,4′-(Methylenedioxy)propiophenone 5,6-Dimethoxy-1-indanone 5-Methoxy-2-hydroxyacetophenone 6-Acetyl-1,4-benzodioxane

3,4-Dimethoxyacetophenone 4',6,7-Trimethoxyisoflavone Paeonol Acetovanillone 3',5-Dihydroxy-4',6,7-trimethoxyflavone

3,7,3',4'-Tetramethylgossypetin 2',3',4'-Trimethoxyacetophenone 2'-Amino-4',5'-dimethoxyacetophenone Eupatorin-5-methyl ether 3',4',5'-Trimethoxyacetophenone

2,3,3',4'-Tetramethoxybenzophenone 6,7-Dimethoxy-2,2-dimethyl-4-chloromanone 1-(4-hydroxyphenyl)-2-methoxyethan-1-one

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1-(3-hydroxy-4-Methoxyphenyl)ethan-1-one 5-Acetyl-2-methoxyphenol Isoacetovanillone NSC 30050 ACETOISOVANILLONE(SH) 3-HYDROXY-4-METHOXYACETOPHENONE 4'-METHOXY-3'-HYDROXYACETOPHENONE 1-(3-hydroxy-4-methoxy-phenyl)ethanone Diosmin EP Impurity A Diosmin Impurity 1 (Diosmin EP Impurity A) 3'-Hydroxy-4'-methoxyacetophenone 97% Isoacetovanillone (1.0 mg/mL in Methanol) -METHOXY-3-HYDROXYACETOPHENONE 1-(3-hydroxy-4-methoxyphenyl)ethan-1-one (acetoisovanillone), 3'-Hydroxy-4'-methoxyacetophenone Dioxamine EP Impurity A Acetoisovanillone Ethanone, 1-(3-hydroxy-4-Methoxyphenyl)- 4-Methoxy-3-hydroxyacetophenone 6100-74-9 Building Blocks C9 Carbonyl Compounds Organic Building Blocks Ketones Aromatic Acetophenones & Derivatives (substituted)