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4-METHOXY-3-HYDROXYACETOPHENONE

4-METHOXY-3-HYDROXYACETOPHENONE structure

CAS No.: 6100-74-9

Chemical Name:: 4-METHOXY-3-HYDROXYACETOPHENONE

Synonyms: 1-(3-hydroxy-4-Methoxyphenyl)ethan-1-one;Acetoisovanillone;Ethanone, 1-(3-hydroxy-4-Methoxyphenyl)-;3-HYDROXY-4-METHOXYACETOPHENONE;Isoacetovanillone;NSC 30050;ACETOISOVANILLONE(SH);Diosmin EP Impurity A;Dioxamine EP Impurity A;5-Acetyl-2-methoxyphenol

CBNumber:: CB3435814

Molecular Formula:: C9H10O3

Molecular Weight:: 166.17

MDL Number:: MFCD00182975

MOL File:: 6100-74-9.mol

MSDS File:: SDS

Last updated:2025-09-11 22:01:37

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4-METHOXY-3-HYDROXYACETOPHENONE Properties

Melting point	88-92 °C
Boiling point	329.9±27.0 °C(Predicted)
Density	1.158
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.15±0.10(Predicted)
color	Off-White to Yellow
Stability	Stable. Incompatible with strong oxidizing agents.
InChI	InChI=1S/C9H10O3/c1-6(10)7-3-4-9(12-2)8(11)5-7/h3-5,11H,1-2H3
InChIKey	YLTGFGDODHXMFB-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(OC)C(O)=C1)C
LogP	1.373 (est)
FDA UNII	286G943O33
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Risk Statements

WGK Germany

HS Code

2914390090

NFPA 704

	0
2		0

4-METHOXY-3-HYDROXYACETOPHENONE price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	679704	3′-Hydroxy-4′-methoxyacetophenone 97%	6100-74-9	1g	$100	2025-07-31	Buy
Sigma-Aldrich	679704	3′-Hydroxy-4′-methoxyacetophenone 97%	6100-74-9	5g	$193	2025-07-31	Buy
TRC	I780000	Isoacetovanillone	6100-74-9	50g	$545	2021-12-16	Buy
Medical Isotopes, Inc.	59229	Isoacetovanillone	6100-74-9	2.5g	$610	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0079203	4-METHOXY-3-HYDROXYACETOPHENONE 95.00%	6100-74-9	1G	$642.18	2021-12-16	Buy

Product number	Packaging	Price	Buy
679704	1g	$100	Buy
679704	5g	$193	Buy
I780000	50g	$545	Buy
59229	2.5g	$610	Buy
CHM0079203	1G	$642.18	Buy

4-METHOXY-3-HYDROXYACETOPHENONE Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

Isoacetovanillone is a volatile compound isolated from oak wood. Also a byproduct in the production of Acetovanillone.

Uses

Isoacetovanillone (Diosmin EP Impurity A) is a volatile compound isolated from oak wood. Also a byproduct in the production of Acetovanillone.

Definition

ChEBI: Isoacetovanillone is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.

Preparation

Preparation by saponification of 3-acetoxy-4-methoxy-acetophenone (90%) (59%).

Synthesis Reference(s)

Synthetic Communications, 18, p. 1379, 1988 DOI: 10.1080/00397918808078806

Synthesis

1-(4-Methoxy-3-propan-2-yloxyphenyl)ethanone

88114-44-7

6100-74-9

General procedure for the synthesis of 4-methoxy-3-hydroxyacetophenone from 3'-hydroxy-4'-methoxyacetophenone (12): ketone 8 (250 mg, 1.20 mmol) was dissolved in anhydrous CH2Cl2 (3 mL), AlCl3 (208 mg, 1.56 mmol) was added, and the reaction was stirred for 24 h at 18 °C and under nitrogen protection. After completion of the reaction, the mixture was partitioned between water (10 mL) and CH2Cl2 (10 mL). The aqueous phase was extracted once with CH2Cl2 (10 mL), the organic phases were combined, dried with MgSO4, filtered and concentrated under reduced pressure. The light yellow oil obtained was purified by fast chromatography (eluent: ethyl acetate/hexane, 1:4 v/v) to give a white solid 4-methoxy-3-hydroxyacetophenone 124 (172 mg, 86% yield) with a melting point of 88.6-90.5 °C (literature value: 92-93 °C) and a TLC (silica gel plate, unfolding agent: ethyl acetate/hexane, 1:1 v/v) Rf value was 0.4. 1H NMR (300MHz, CDCl3) δ: 7.53-7.56 (m, 2H), 6.89 (d, J=7.5Hz, 1H), 5.73 (br s, 1H), 3.96 (s, 3H), 2.54 (s, 3H).

References

[1] Patent: WO2008/124878, 2008, A1. Location in patent: Page/Page column 38

4-METHOXY-3-HYDROXYACETOPHENONE synthesis

Synthesis of 4-METHOXY-3-HYDROXYACETOPHENONE from 3,4-Dihydroxyacetophenone and Iodomethane

4-METHOXY-3-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

1-(4-Methoxy-3-propan-2-yloxyphenyl)ethanone 2-METHOXYPHENYL ACETATE 3-ISOPROPOXY-4-METHOXY-BENZALDEHYDE 3,4-Dihydroxyacetophenone 3,4-Dimethoxyacetophenone

Aluminum chloride Iodomethane Acetovanillone Vanillin Acetic anhydride

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Preparation Products

4-METHOXY-3-HYDROXYACETOPHENONE Suppliers

Global( 181)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	925	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3751	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2953	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Speranza Chemical Co., Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Shanghai Standard Technology Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 4-METHOXY-3-HYDROXYACETOPHENONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-11	3-Hydroxy-4-methoxyacetophenone 6100-74-9	US $0.00 / removed		97.03%	10g	TargetMol Chemicals Inc.
2025-09-11	3-Hydroxy-4-methoxyacetophenone 6100-74-9	US $0.00 / removed		97.03%	10g	TargetMol Chemicals Inc.
2025-05-26	4-METHOXY-3-HYDROXYACETOPHENONE 6100-74-9	US $10.70 / KG	10KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

3-Hydroxy-4-methoxyacetophenone
6100-74-9
US $0.00 / removed
97.03%
TargetMol Chemicals Inc.

3-Hydroxy-4-methoxyacetophenone
6100-74-9
US $0.00 / removed
97.03%
TargetMol Chemicals Inc.

4-METHOXY-3-HYDROXYACETOPHENONE
6100-74-9
US $10.70 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

4-METHOXY-3-HYDROXYACETOPHENONE Spectrum

4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)MS 4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)¹HNMR 4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)IR1 4-METHOXY-3-HYDROXYACETOPHENONE(6100-74-9)IR2

6100-74-9(4-METHOXY-3-HYDROXYACETOPHENONE)Related Search:

3,4-Methylenedioxyacetophenone 3′,4′-(Methylenedioxy)propiophenone 5,6-Dimethoxy-1-indanone 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE 2,3,3',4'-TETRAMETHOXYBENZOPHENONE

3,7,3',4'-TETRAMETHYLGOSSYPETIN 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE EUPATORIN-5-METHYL ETHER 2',3',4'-TRIMETHOXYACETOPHENONE 3',4',5'-TRIMETHOXYACETOPHENONE

3,4-Dimethoxyacetophenone 4',6,7-Trimethoxyisoflavone 6-Acetyl-1,4-benzodioxane 4'-METHOXY-2'-HYDROXYACETOPHENONE,4-METHOXY-2-HYDROXYACETOPHENONE,Methoxy-2-hydroxyAcetophenone 5-Methoxy-2-hydroxyacetophenone

Acetovanillone 6,7-DIMETHOXY-2,2-DIMETHYL-4-CHLOROMANONE Santalin

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Acetoisovanillone 1-(3-hydroxy-4-Methoxyphenyl)ethan-1-one Ethanone, 1-(3-hydroxy-4-Methoxyphenyl)- 5-Acetyl-2-methoxyphenol Isoacetovanillone NSC 30050 ACETOISOVANILLONE(SH) 3-HYDROXY-4-METHOXYACETOPHENONE 4'-METHOXY-3'-HYDROXYACETOPHENONE 4-METHOXY-3-HYDROXYACETOPHENONE 1-(3-hydroxy-4-methoxy-phenyl)ethanone Diosmin EP Impurity A Diosmin Impurity 1 (Diosmin EP Impurity A) 3'-Hydroxy-4'-methoxyacetophenone 97% Isoacetovanillone (1.0 mg/mL in Methanol) -METHOXY-3-HYDROXYACETOPHENONE 1-(3-hydroxy-4-methoxyphenyl)ethan-1-one (acetoisovanillone), 3'-Hydroxy-4'-methoxyacetophenone Dioxamine EP Impurity A 6100-74-9 Building Blocks C9 Carbonyl Compounds Organic Building Blocks Ketones Aromatic Acetophenones & Derivatives (substituted)