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| | 4-Methoxy-3-hydroxyacetophenone Basic information |
| | 4-Methoxy-3-hydroxyacetophenone Chemical Properties |
| Melting point | 88-92 °C | | Boiling point | 329.9±27.0 °C(Predicted) | | density | 1.158 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 9.15±0.10(Predicted) | | color | Off-White to Yellow | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | InChI=1S/C9H10O3/c1-6(10)7-3-4-9(12-2)8(11)5-7/h3-5,11H,1-2H3 | | InChIKey | YLTGFGDODHXMFB-UHFFFAOYSA-N | | SMILES | C(=O)(C1=CC=C(OC)C(O)=C1)C | | LogP | 1.373 (est) |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | HS Code | 2914390090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 4-Methoxy-3-hydroxyacetophenone Usage And Synthesis |
| Chemical Properties | solid | | Uses | Isoacetovanillone is a volatile compound isolated from oak wood. Also a byproduct in the production of Acetovanillone. | | Uses | Isoacetovanillone (Diosmin EP Impurity A) is a volatile compound isolated from oak wood. Also a byproduct in the production of Acetovanillone. | | Definition | ChEBI: Isoacetovanillone is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite. | | Preparation | Preparation by saponification of 3-acetoxy-4-methoxy-acetophenone (90%) (59%). | | Synthesis Reference(s) | Synthetic Communications, 18, p. 1379, 1988 DOI: 10.1080/00397918808078806 | | Synthesis | General procedure for the synthesis of 4-methoxy-3-hydroxyacetophenone from 3'-hydroxy-4'-methoxyacetophenone (12): ketone 8 (250 mg, 1.20 mmol) was dissolved in anhydrous CH2Cl2 (3 mL), AlCl3 (208 mg, 1.56 mmol) was added, and the reaction was stirred for 24 h at 18 °C and under nitrogen protection. After completion of the reaction, the mixture was partitioned between water (10 mL) and CH2Cl2 (10 mL). The aqueous phase was extracted once with CH2Cl2 (10 mL), the organic phases were combined, dried with MgSO4, filtered and concentrated under reduced pressure. The light yellow oil obtained was purified by fast chromatography (eluent: ethyl acetate/hexane, 1:4 v/v) to give a white solid 4-methoxy-3-hydroxyacetophenone 124 (172 mg, 86% yield) with a melting point of 88.6-90.5 °C (literature value: 92-93 °C) and a TLC (silica gel plate, unfolding agent: ethyl acetate/hexane, 1:1 v/v) Rf value was 0.4. 1H NMR (300MHz, CDCl3) δ: 7.53-7.56 (m, 2H), 6.89 (d, J=7.5Hz, 1H), 5.73 (br s, 1H), 3.96 (s, 3H), 2.54 (s, 3H). | | References | [1] Patent: WO2008/124878, 2008, A1. Location in patent: Page/Page column 38 |
| | 4-Methoxy-3-hydroxyacetophenone Preparation Products And Raw materials |
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