4-Nitrophenylglyoxylic acid
- CAS No.
- 14922-36-2
- Chemical Name:
- 4-Nitrophenylglyoxylic acid
- Synonyms
- 2-(4-NITROPHENYL)-2-OXOACETIC ACID;SKL212;2-(4-Nitrophenyl);4-Nitrobenzoylformic acid;p-Nitrobenzoylformic acid;4-nitrophenylglyoxilic acid;4-Nitrophenylglyoxylic acid;(4-Nitrophenyl)(oxo)acetic acid;2-(4-Nitrophenyl)glyoxylic acid;4-Nitro-a-oxobenzeneacetic acid
- CBNumber:
- CB9260458
- Molecular Formula:
- C8H5NO5
- Molecular Weight:
- 195.13
- MDL Number:
- MFCD00051744
- MOL File:
- 14922-36-2.mol
- MSDS File:
- SDS
| Melting point | 113-115°C |
|---|---|
| Boiling point | 381.6±34.0 °C(Predicted) |
| Density | 1.531±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 1.72±0.54(Predicted) |
| form | powder |
| color | Yellow |
| BRN | 1213023 |
| InChI | InChI=1S/C8H5NO5/c10-7(8(11)12)5-1-3-6(4-2-5)9(13)14/h1-4H,(H,11,12) |
| InChIKey | RREPYIWLDJQENS-UHFFFAOYSA-N |
| SMILES | C(=O)(C(=O)O)C1=CC=C([N+]([O-])=O)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HS Code | 2921490090 |
4-Nitrophenylglyoxylic acid price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-N232260-500MG | 4-Nitrophenylglyoxylic Acid | 14922-36-2 | 500mg | $319 | 2026-06-03 | Buy |
| TRC | TRC-N232260-1G | 4-Nitrophenylglyoxylic Acid | 14922-36-2 | 1g | $551 | 2026-06-03 | Buy |
| TRC | TRC-N232260-100MG | 4-Nitrophenylglyoxylic Acid | 14922-36-2 | 100mg | $96 | 2026-06-03 | Buy |
| Matrix Scientific | 296578 | 2-(4-Nitrophenyl)-2-oxoacetic acid | 14922-36-2 | 1.00g | $78 | 2026-05-19 | Buy |
| Matrix Scientific | 296578 | 2-(4-Nitrophenyl)-2-oxoacetic acid | 14922-36-2 | 5.00g | $330 | 2026-05-19 | Buy |
4-Nitrophenylglyoxylic acid Chemical Properties,Uses,Production
Uses
4-Nitrophenylglyoxylic acid (CAS# 14922-36-2) is a useful research chemical compound for organic synthesis and other chemical processes.
Synthesis
100-19-6
14922-36-2
General procedure for the synthesis of 2-(4-nitrophenyl)-2-oxoacetic acid from p-nitroacetophenone: Selenium dioxide (SeO2, 0.167 g, 1.5 mmol) and p-nitroacetophenone (0.165 g, 1 mmol) were added to a 25 mL round-bottomed flask under nitrogen protection. 10 mL of anhydrous pyridine was added and the reaction mixture was heated to 110 °C in an oil bath and refluxed with stirring. After 1 h of reaction, the reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature and allowed to stand for 4 hours. The precipitate containing SeO2 was removed by filtration through a Brinell funnel and the residue was washed with 50 mL of ethyl acetate. The filtrates were combined and treated with 1 mmol/L hydrochloric acid (20 mL). The aqueous layer was extracted three times with ethyl acetate (50 mL) to obtain aqueous layer 2 and organic layer 2, respectively. organic layer 2 was combined and extracted three times with 25 mL of water to obtain organic layer 3 and aqueous layer 3. aqueous layer 3 was treated with 1 mmol/L NaOH (50 mL) to obtain the reaction solution. The filtrate 4 was diluted and combined into the aqueous layer 2, and the pH was adjusted to 1.5 with 1 mmol/L hydrochloric acid.The mixture was extracted with ethyl acetate (3 × 50 mL). The organic layer was dried overnight in a vacuum desiccator to give the product 4-nitrophenylglyoxalic acid in a yield of 0.154 g in 79.2% yield.
References
[1] Synthetic Communications, 2008, vol. 38, # 24, p. 4434 - 4444
[2] Patent: CN108623611, 2018, A. Location in patent: Paragraph 0041; 0043; 0044; 0045; 0046
[3] Journal of Organic Chemistry, 2018, vol. 83, # 3, p. 1422 - 1430
[4] Journal of the American Chemical Society, 2010, vol. 132, # 34, p. 11898 - 11899
[5] Chemical Communications, 2013, vol. 49, # 35, p. 3640 - 3642
4-Nitrophenylglyoxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Nitrophenylglyoxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing YiboYuntian Technology Co., Ltd. | 13811826434 | lichen13811826434@126.com | China | 697 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
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| Shanghai Jovan Biochemical Technology Co. Ltd. | +86-021-61654350 | 1245958370@qq.com | China | 2979 | 50 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Qiandu Biological Technology Co., Ltd. | 021-61535850 | 2911799694@qq.com | China | 207 | 58 |
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