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6-Hydroxy-5-nitronicotinic acid

6-Hydroxy-5-nitronicotinic acid Structure
6-Hydroxy-5-nitronicotinic acid structure
CAS No.
6635-31-0
Chemical Name:
6-Hydroxy-5-nitronicotinic acid
Synonyms
135339;6-Hydroxy-5-Nitro Niacin;6-hyroxy-5-nitronicotinic acid;Linaprazan Glurate Impurity 51;6-HYDROXY-5-NITRONICOTINIC ACID;5-Nitro-6-hydroxynicotinic acid;6-Hydroxy-5-nitronicotinicAcid>5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE;6-Hydroxy-5-nitronicotinic acid 97%;6-Hydroxy-5-nitropyridine-3-carboxylicaci
CBNumber:
CB3671957
Molecular Formula:
C6H4N2O5
Molecular Weight:
184.11
MDL Number:
MFCD02180840
MOL File:
6635-31-0.mol
MSDS File:
SDS
Last updated:2026-05-28 04:13:14
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6-Hydroxy-5-nitronicotinic acid Properties

Melting point 269-271
Boiling point 363.6±42.0 °C(Predicted)
Density 1.70±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 3.09±0.50(Predicted)
form powder to crystal
color Light yellow to Yellow
BRN 177986
InChI InChI=1S/C6H4N2O5/c9-5-4(8(12)13)1-3(2-7-5)6(10)11/h1-2H,(H,7,9)(H,10,11)
InChIKey VJMXJGVEVASJOD-UHFFFAOYSA-N
SMILES C1NC(=O)C([N+]([O-])=O)=CC=1C(O)=O
CAS DataBase Reference 6635-31-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H335
Precautionary statements  P261-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37
Safety Statements  26
WGK Germany  3
Hazard Note  Irritant/Keep Cold
HazardClass  IRRITANT
HS Code  2933399990
Storage Class 13 - Non Combustible Solids
Hazard Classifications Eye Irrit. 2
STOT SE 3
NFPA 704
0
2 0

6-Hydroxy-5-nitronicotinic acid price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 669679 6-Hydroxy-5-nitropyridine-3-carboxylic acid 97% 6635-31-0 1g $118 2022-05-15 Buy
Sigma-Aldrich 669679 6-Hydroxy-5-nitropyridine-3-carboxylic acid 97% 6635-31-0 5g $704 2022-05-15 Buy
TCI Chemical H1410 6-Hydroxy-5-nitronicotinic Acid >97.0%(GC)(T) 6635-31-0 1g $105 2024-03-01 Buy
TCI Chemical H1410 6-Hydroxy-5-nitronicotinic Acid >97.0%(GC)(T) 6635-31-0 5g $360 2024-03-01 Buy
AstaTech CX1103 6-HYDROXY-5-NITRO NICOTINIC ACID 97% 6635-31-0 5G $30 2026-04-30 Buy
Product number Packaging Price Buy
669679 1g $118 Buy
669679 5g $704 Buy
H1410 1g $105 Buy
H1410 5g $360 Buy
CX1103 5G $30 Buy

6-Hydroxy-5-nitronicotinic acid Chemical Properties, Uses, Production

Uses

6-Hydroxy-5-nitronicotinic acid is mainly used as an antibacterial agent and pharmaceutical intermediate.

Application

6-Hydroxy-5-nitronicotinic acid serves as a multifunctional building block in medicinal and agrochemical synthesis: it acts as an antimicrobial agent, a pharmaceutical intermediate for vitamin B3 derivatives and other bio-actives, and a lead compound for antitumor, anti-inflammatory, antifungal and antiviral drug discovery.

Chemical Reactivity

6-Hydroxy-5-nitronicotinic acid is stable under proper conditions, it reacts with oxidizing agents.

Synthesis

6-Hydroxy-5-nitronicotinic acid is synthesised using 6-Hydroxynicotinic acid as a raw material by chemical reaction. The specific synthesis steps are as follows:
6-Hydroxynicotinic acid 2 (25.0 g, 180 mmol) was dissolved in HNO3 fuming (1.52) (95 mL) and stirred at 50 oC for 18 h. After the solution was cooled to room temperature, the mixture was concentrated, and then co-evaporated with water, followed by the addition of MeOH to afford a brown precipitate. The precipitate was filtered and washed with 50 mL of cold MeOH twice. After drying under reduced pressure, a brown color product 3 was obtained; yield: 9.67 g (29percent); 1H NMR (300 MHz, CD3OD) 8.44 (d, J = 2.6 Hz, 1H), 8.85 (d, J = 2.6 Hz, 1H) ; HRMS (ES+): m/z 185.0194 (M+H+) (calcd for C6H5N2O5: 185.0198).
6-Hydroxy-5-nitronicotinic acid synthesis

References

[1] Tetrahedron Letters, 1999, vol. 40, # 12, p. 2227 - 2230
[2] Tetrahedron Letters, 2012, vol. 53, # 5, p. 535 - 538
[3] Patent: WO2016/138335, 2016, A1. Location in patent: Paragraph 00372
[4] Journal of the American Chemical Society, 1956, vol. 78, p. 423
[5] Journal of the Chemical Society, 1951, p. 2590,2593

6-Hydroxy-5-nitronicotinic acid Preparation Products And Raw materials

Raw materials

2-Chloro-5-methyl-3-nitropyridine 2-Hydroxy-5-pyridinecarboxylic acid

Preparation Products

Methyl-6-chloro-5-nitronicotinate

6-Hydroxy-5-nitronicotinic acid Suppliers

Global Suppliers ( 284)
Supplier Tel Email Country ProdList Advantage
NanJing Jiexin chemicals Co.,Ltd 15005178685; 15005178685 1347015058@qq.com China 61 58
Shanghai Jinsheng Pharmaceutical Co., Ltd. 1365-13651960330 13651960330 xiangfeixia@jspharmatech.com China 401 58
Shandong Zhonghan Pharmaceutical Co.,Ltd. 15315818580 18562151612 2289008634@qq.com China 296 55
Jinan Grenda Medical Technology Co., Ltd. 13287705608 13287705608 xiaoya198706@126.com China 432 58
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375880 15098789112 3845379039@qq.com China 1458 58
Nanjing Lirui Pharmaceutical Trading Co., Ltd. 15951922363 wendy@lyripharma.com China 499 58
Zhongke Pingsheng (Dalian) New Materials Co., Ltd. 18841123239 1798136513@qq.com China 128 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
ZHIWE CHEMTECH CO LTD 021-20221225 13917446399 zwchem@163.com China 527 61
Supplier Advantage
NanJing Jiexin chemicals Co.,Ltd 58
Shanghai Jinsheng Pharmaceutical Co., Ltd. 58
Shandong Zhonghan Pharmaceutical Co.,Ltd. 55
Jinan Grenda Medical Technology Co., Ltd. 58
Jinan Dexinjia Bio&Tech Co., Ltd 58
Nanjing Lirui Pharmaceutical Trading Co., Ltd. 58
Zhongke Pingsheng (Dalian) New Materials Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
ZHIWE CHEMTECH CO LTD 61

View Latest Price from 6-Hydroxy-5-nitronicotinic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Hydroxy-5-nitronicotinic acid pictures 2026-09-02 6-Hydroxy-5-nitronicotinic acid
6635-31-0
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
6-Hydroxy-5-nitronicotinic acid pictures 2026-08-20 6-Hydroxy-5-nitronicotinic acid
6635-31-0
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
6-Hydroxy-5-nitronicotinic acid pictures 2026-06-30 6-Hydroxy-5-nitronicotinic acid
6635-31-0
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

6-Hydroxy-5-nitronicotinic acid Spectrum

6-Hydroxy-5-nitronicotinic acid(6635-31-0)1HNMR6-Hydroxy-5-nitronicotinic acid(6635-31-0)FT-IR

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6-HYDROXY-5-NITRONICOTINIC ACID 2-HYDROXY-3-NITRO-5-PYRIDINECARBOXYLIC ACID 2-HYDROXY-3-NITROPYRIDINE-5-CARBOXYLIC ACID 6-Hydroxy-5-nitronicotinic acid 97% 5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE 6-hyroxy-5-nitronicotinic acid 6-Hydroxy-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-hydroxy-3-nitropyridine 135339 6-Hydroxy-5-nitronicotinicAcid> 3-Pyridinecarboxylic acid, 1,6-dihydro-5-nitro-6-oxo- 6-Hydroxy-5-nitropyridine-3-carboxylicaci 6-Hydroxy-5-nitro-3-pyridinecarboxylic Acid 6-Hydroxy-5-nitronicotinic acid ISO 9001：2015 REACH 6-Hydroxy-5-Nitro Niacin 5-Nitro-6-hydroxynicotinic acid 6-Hydroxy-5-nitropyridine-3-carboxylic acid, CAS 6635-31-0 6-Hydroxy-5-nitropyridin-3-carboxylic acid Linaprazan Glurate Impurity 51 5-nitro-6-oxo-1H-pyridine-3-carboxylic acid 6635-31-0 6365-31-0 CHIRAL CHEMICALS blocks Carboxes NitroCompounds Pyridines