5-Aminonicotinic acid
- CAS No.
- 24242-19-1
- Chemical Name:
- 5-Aminonicotinic acid
- Synonyms
- 5-AMINOPYRIDINE-3-CARBOXYLIC ACID;AURORA KA-3032;JACS-24242-19-1;AKOS BBS-00001362;IFLAB-BB F1926-0005;5-Ammonionicotinate;5-Aminonicotinic aci;OTAVA-BB BB7017520056;5-AMINONICOTINIC ACID;5-AMINOISOPHTHALICACID
- CBNumber:
- CB0248990
- Molecular Formula:
- C6H6N2O2
- Molecular Weight:
- 138.12
- MDL Number:
- MFCD00129116
- MOL File:
- 24242-19-1.mol
- MSDS File:
- SDS
| Melting point | 293 °C |
|---|---|
| Boiling point | 253.51°C (rough estimate) |
| Density | 1.3471 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.36±0.10(Predicted) |
| form | Crystalline Powder |
| color | Golden-brown |
| BRN | 115848 |
| InChI | InChI=1S/C6H6N2O2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,7H2,(H,9,10) |
| InChIKey | BYIORJAACCWFPU-UHFFFAOYSA-N |
| SMILES | C1=NC=C(N)C=C1C(O)=O |
| CAS DataBase Reference | 24242-19-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22-22 | |||||||||
| Safety Statements | 36/37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
5-Aminonicotinic acid price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 672513 | 5-Aminopyridine-3-carboxylic acid 97% | 24242-19-1 | 1g | $144 | 2026-04-30 | Buy |
| Sigma-Aldrich | 672513 | 5-Aminopyridine-3-carboxylic acid 97% | 24242-19-1 | 5g | $541 | 2023-06-20 | Buy |
| TCI Chemical | A2000 | 5-Aminonicotinic Acid >98.0%(HPLC)(T) | 24242-19-1 | 5g | $36 | 2026-04-30 | Buy |
| TCI Chemical | A2000 | 5-Aminonicotinic Acid >98.0%(HPLC)(T) | 24242-19-1 | 25g | $144 | 2026-04-30 | Buy |
| Activate Scientific | AS4079 | 5-Aminonicotinic acid 98% | 24242-19-1 | 5g | $18 | 2026-06-04 | Buy |
5-Aminonicotinic acid Chemical Properties, Uses, Production
Chemical Properties
Off-white Cryst
Uses
5-Aminonicotinic acid is used in the synthesis of coordination polymers, bioluminescent reagents and biological active agents.
Definition
ChEBI: 5-aminonicotinic acid is an aminonicotinic acid in which the amino group is situated at position 5 of the pyridine ring. It has a role as a metabolite. It is an aromatic amine, an aminopyridine and an aminonicotinic acid. It is functionally related to a nicotinic acid.
Application
5-aminonicotinic acid is an aminonicotinic acid, it is mainly used as a biochemical reagent and pharmaceutical chemical intermediate.
Hazard
5-Aminonicotinic acid has acute oral toxicity and acute dermal toxicity, it causes skin irritation and serious eye irritation.
Synthesis
20826-04-4
24242-19-1
The general procedure for the synthesis of 5-aminonicotinic acid from 5-bromonicotinic acid was as follows: 5-bromo-3-pyridinecarboxylic acid (25 g, 0.124 mol) was mixed with ammonia (67.32 mL) and copper sulfate pentahydrate (8.41 g) was added. The reaction mixture was transferred to an autoclave, heated to 120 °C and kept for 16 hours. The reaction process was monitored by thin layer chromatography (TLC) using ninhydrin as a color developer. Upon completion of the reaction, the reaction mixture was washed with saturated sodium sulfide solution to remove copper ions, followed by adjusting the pH to 4-5 with concentrated hydrochloric acid.The acidified mixture was cooled to precipitate solids. The solid product was collected by filtration and dried to give 5-aminonicotinic acid (12.9 g, 74% yield).
References
[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[2] Patent: WO2004/35545, 2004, A2. Location in patent: Page 46
[3] Patent: WO2003/101959, 2003, A1. Location in patent: Page 50-51
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1981, vol. 35, # 4, p. 289 - 294
[5] Journal of the American Chemical Society, 1948, vol. 70, p. 2381,2383
5-Aminonicotinic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang C-element Biotech Co.,Ltd | +86-18033710157 18033710157 | Lisa@C-elementBiotech.com | China | 234 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 5-Aminonicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-05-14 | 5-Aminonicotinic acid
24242-19-1
|
98% | 500KG/month | Shijiazhuang Dowell Chemical Co.,Ltd | |||
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2025-04-04 | 5-Aminonicotinic acid
24242-19-1
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
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2022-02-25 | 5-Ammonionicotinate
24242-19-1
|
$20.00 | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- 5-Aminonicotinic acid
24242-19-1
- 98%
- Shijiazhuang Dowell Chemical Co.,Ltd
-
- 5-Aminonicotinic acid
24242-19-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Ammonionicotinate
24242-19-1
- $20.00
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
