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Nafarelin

Nafarelin structure

CAS No.: 76932-56-4

Chemical Name:: Nafarelin

Synonyms: Synarel;Nacenyl;C07613;Nasanyl;RS-94991;AI314925;NAFARELIN;Synrelina;AI3 14925;AI3-14925

CBNumber:: CB4246893

Molecular Formula:: C66H83N17O13

Molecular Weight:: 1322.47

MDL Number:: MFCD00871253

MOL File:: 76932-56-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:27:04

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Nafarelin Properties

Density	1.49±0.1 g/cm3(Predicted)
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
pka	9.82±0.15(Predicted)
form	Solid
color	White to Off-White
InChIKey	RWHUEXWOYVBUCI-ITQXDASVSA-N
EWG's Food Scores	1
FDA UNII	1X0094V6JV
ATC code	H01CA02

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360
HS Code	3504009000

Nafarelin price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	255938	Nafarelin ≥95%	76932-56-4	10mg	$389	2026-06-03	Buy
Usbiological	255938	Nafarelin ≥95%	76932-56-4	50mg	$934	2026-06-03	Buy
Biosynth	FN65097	Nafarelin acetate	76932-56-4	50mg	$478.5	2026-06-04	Buy
ApexBio Technology	C6444	Nafarelin Acetate	76932-56-4	10mg	$50	2026-05-06	Buy
ApexBio Technology	C6444	Nafarelin Acetate	76932-56-4	50mg	$120	2026-05-06	Buy

Product number	Packaging	Price	Buy
255938	10mg	$389	Buy
255938	50mg	$934	Buy
FN65097	50mg	$478.5	Buy
C6444	10mg	$50	Buy
C6444	50mg	$120	Buy

Nafarelin Chemical Properties,Uses,Production

Description

Nafarelin is a gonadorelin analogue. It produces an initial phase of stimulation followed by down-regulation of gonadotrophin-releasing hormone receptors, thus reducing the release of FSH and LH, leading to inhibition of androgen and oestrogen production.

Chemical Properties

Nafarelin is a synthetic analogue of gonadotrophin-releasing hormone (GnRH), which is about 200 times more potent than the native hormone and is more resistant to proteolysis Chrisp and Goa (1990), Parker and Schimmer (2001). Like GnRH, it binds with high affinity to the GnRH receptor on anterior pituitary cells, where it acts as an agonist.

Originator

Nafarelin Acetate,Bachem AG

Uses

LHRH agonist.

brand name

Synarel (Searle).

Therapeutic Function

Gonadotropic

Biological Functions

Acutely, Nafarelin stimulates the secretion of LH and FSH from the anterior pituitary, but prolonged, continuous exposure leads to inhibition of secretion by desensitization of the pituitary gonadotropes Vickery (1985). The initial stimulation of gonadotrophin secretion results in an increase in serum concentrations of estradiol in females and testosterone in males. These then decrease to very low concentrations equivalent to those found in menopausal women and castrated men respectively.

Clinical Use

Nafarelin has potential wide therapeutic applications in the treatment of endometriosis, uterine leiomyoma (fibroids), malignant neoplasms, and in assisted reproduction protocols. However, its use is currently restricted to the treatment of endometriosis and in assisted reproduction protocols.

Side effects

Nafarelin does not have the same androgenic adverse effects as danazol, but it can cause menopausal symptoms. The most commonly reported symptoms are hot flushes, vaginal dryness, altered libido and headaches. Treatment for 6 months results in a loss of bone density. The vertebral trabecular bone density falls by nearly 9% and may not return to normal after treatment. Nafarelin also has a similar effect to oestrogen deficiency on blood lipids e.g. concentrations of total cholesterol and triglycerides may increase.

Synthesis

i. 1 mmol from preparation A was placed in the reaction vessel of a 5 L Vega 296 automatic solid phase peptide synthesizer.
ii. Following amino acids were added to the Preparation A resin:
Nα-Boc-Pro 2 equiv.
Nα-Boc-Arg 2 equiv.
Nα-Boc-Leu 2 equiv.
Nα-Boc-D-NaI 1.5 equiv.
Nα-Boc-Tyr 1.5 quiv
Nα-Boc-Ser(tBu) 2 equiv.
Nα-Boc-Trp 1.75 equiv.
Nα-Boc-His(tos) 1.75 equiv.
(pyro)Glu 2.5 equiv.
iii. Crude peptide was dissolved in 2M acetic acid and converted to acetate salt by passage through a column of AG3-X4A resin.
iv. Acetate was dissolved in minimal amount of methanol.
v. It was then reprecipitated using acetone.
vi. It was then purified using HPLC to get the Nafarelin.

Nafarelin Preparation Products And Raw materials

Raw materials

Ethyl acetamidocyanoacetate Benzhydrylamine COBALT(III) FLUORIDE 1-Boc-Pyrrolidine Boc-3-(2-Naphthyl)-D-alanine

N-[(tert-Butoxy)carbonyl]-L-tryptophan BOC-L-Leucine Hydrogen fluoride BOC-Glycine BOC-L-Proline

1-Hydroxybenzotriazole Dicyclohexylcarbodiimide

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Preparation Products

Nafarelin Suppliers

Global( 191)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	1010	55
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8137	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7236	62
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58

Supplier	Advantage
Cellmano Biotech Limited	55
MedBioPharmaceutical Technology Inc	58
Shanghai Boyle Chemical Co., Ltd.	55
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
LGM Pharma	70
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62
Beijing HuaMeiHuLiBiological Chemical	58

View Lastest Price from Nafarelin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-10-12	(D-2-Nal6)-LHRH acetate salt 76932-56-4	$50.00	1g	99%	500t	Shanghai Yunao International Trade Co., Ltd
2023-10-11	(D-2-Nal6)-LHRH acetate salt 76932-56-4		1g	99.9%	1000000000000	Shanghai Yunao International Trade Co., Ltd
2021-07-13	Nafarelin Acetate 76932-56-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

(D-2-Nal6)-LHRH acetate salt
76932-56-4
$50.00
99%
Shanghai Yunao International Trade Co., Ltd

(D-2-Nal6)-LHRH acetate salt
76932-56-4
99.9%
Shanghai Yunao International Trade Co., Ltd

Nafarelin Acetate
76932-56-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Nafarelin Spectrum

Nafarelin(76932-56-4)MS

76932-56-4(Nafarelin)Related Search:

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Nafarelin Acetate Nafarelin Gonadorelin 3-(Naphthalen-2-yl)propan-1-amine Nafarelin Acetate (NAF)

PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-NHET PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 NAFARELIN ACETATE

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(D-2-NAL6)-LHRH NAFARELIN 98.0+% Nafareline C07613 Pyr-His-Trp-Ser-Tyr-D-2-Nal-Leu-Arg-Pro-Gly-NH2 acetate salt Nasanyl RS-94991-298 Synrelina ala(2-naphthyl)(6)-lhr PYR-HIS-TRP-SER-TYR-D-2-NAL-LEU-ARG-PRO-GLY-NH2 NAFARELIN N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(2-naphthalenyl)-1-oxopro Nafarelin, >98% 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-3-(2-naphtyl)-D-Ala-L-Leu-L-Arg-L-Pro-Gly-NH2 RS-94991 Lhrh, Ala(2-naphthyl)(6)- Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)- Nafarelin [inn:ban] Nafarelina Nafarelina [spanish] (D-2-Nal6)-LHRH Nafarelin 6-(3-(2-naphthalenyl)-d-alanine)-luteinizinghormone-releasingfactor(pig 6-(3-(2-naphthalenyl)-d-alanine)luteinizinghormone-releasingfactor(pig) Nafarelin Acetate|(D-2-Nal6)-LHRH Luteinizing hormone-releasing factor (swine), 6-[3-(2-naphthalenyl)-D-alanine]- Nafarelin USP/EP/BP (D-2-Nal6)-LHRH acetate salt TIANFU-CHEM_Nafarelin 76932-56-4 99.0% Nafarelin Acetate, Nafarelina AI3 14925 AI314925 AI3-14925 Nafarelin acetate salt Nacenyl Synarel 76932-56-4 C66H83N17O13 hormones