Ethyl 1-Cbz-piperidine-2-carboxylate
- CAS No.
- 126401-22-7
- Chemical Name:
- Ethyl 1-Cbz-piperidine-2-carboxylate
- Synonyms
- Ethyl 1-Cbz-piperidine-2-carboxylate;1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate;1,2-Piperidinedicarboxylic acid, 2-ethyl 1-(phenylMethyl) ester
- CBNumber:
- CB42583028
- Molecular Formula:
- C16H21NO4
- Molecular Weight:
- 291.34
- MDL Number:
- MOL File:
- 126401-22-7.mol
- MSDS File:
- SDS
Ethyl 1-Cbz-piperidine-2-carboxylate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD11303963 | 1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate 97% | 126401-22-7 | 100g | $446 | 2026-05-26 | Buy |
| Chemenu | CM179849 | 1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate 97% | 126401-22-7 | 100g | $80 | 2026-05-26 | Buy |
| aablocks | AA000SOQ | 1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate 98% | 126401-22-7 | 5g | $18 | 2026-05-25 | Buy |
| aablocks | AA000SOQ | 1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate 97% | 126401-22-7 | 25g | $29 | 2026-05-25 | Buy |
| aablocks | AA000SOQ | 1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate 98% | 126401-22-7 | 100g | $110 | 2026-05-25 | Buy |
Ethyl 1-Cbz-piperidine-2-carboxylate Chemical Properties, Uses, Production
Synthesis
501-53-1
15862-72-3
126401-22-7
A dichloromethane solution of benzyl chloroformate (17 g, 100 mmol) was added slowly and dropwise to a stirred dichloromethane (100 ml) solution of ethyl 2-piperidinecarboxylate (15 g, 95 mmol), triethylamine (27 ml, 191 mmol), and 4-dimethylaminopyridine (0.58 g, 4.8 mmol) at 0 °C. The reaction mixture was slowly warmed up to room temperature and stirred continuously at room temperature for 16 hours (overnight) followed by standing for 2 days. After completion of the reaction, the crude product was extracted with dichloromethane and washed sequentially with 1N hydrochloric acid, saturated aqueous sodium bicarbonate solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by column chromatography on silica gel 60 (300 g) with cyclohexane/ethyl acetate as eluent to afford the light yellow oily target product ethyl N-Cbz-piperidine-2-carboxylate. Yield: 17.9 g (62% yield). The product was analyzed by HPLC (Method 6): retention time Rt = 4.91 min, maximum absorption wavelength λmax = 202 nm; mass spectrometry (ESI positive ion mode): m/z = 309 ([M+NH4]+).
References
[1] Patent: WO2005/82864, 2005, A1. Location in patent: Page/Page column 41-42
[2] Journal of the American Chemical Society, 2011, vol. 133, # 49, p. 19698 - 19701
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 42, p. 10660 - 10663
[4] Angew. Chem., 2012, vol. 124, # 42, p. 10815 - 10819,5
Ethyl 1-Cbz-piperidine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Acesys Pharmatech | 18860950986 | tangmanman@zenjipharma.com | China | 1731 | 55 |
| Chengdu Research Accelerators Technology Co., Ltd. | 028-64353063 | reacchemical@163.com | China | 5243 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Guangdong wengjiang Chemical Reagent Co., Ltd. | 0751-2815688 13927872512 | 3007421951@qq.com | China | 9996 | 58 |
| Aishilun biotechnology (Shanghai) co., LTD | 021-50676523 18019098996 | info@acelybio.com | China | 3950 | 58 |
View Latest Price from Ethyl 1-Cbz-piperidine-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE
126401-22-7
|
$2.00 | 1g | 98%min | Career Henan Chemical Co |
-
- ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE
126401-22-7
- $2.00
- 98%min
- Career Henan Chemical Co
