Ethyl N- Cbz -piperidine-4-carboxylate
- CAS No.
- 160809-38-1
- Chemical Name:
- Ethyl N- Cbz -piperidine-4-carboxylate
- Synonyms
- 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;Ethyl 1-Cbz-piperidine-4-carboxylate;Ethyl N- Cbz -piperidine-4-carboxylate;1-O-benzyl 4-O-ethyl piperidine-1,4-dicarboxylate;4-Ethyl 1-(phenylmethyl) 1,4-piperidinedicarboxylate;Piperidine derivative Ethyl-N-CBZ-piperidine-4-carboxylate;1,4-Piperidinedicarboxylic acid, 4-ethyl 1-(phenylMethyl) ester;piperidine-1,4-dicarboxylic acid O4-ethyl ester O1-(phenylmethyl) ester;Piperidine derivative CAS NO.160809-38-1 Ethyl-N-CBZ-piperidine-4-carboxylate
- CBNumber:
- CB11516451
- Molecular Formula:
- C16H21NO4
- Molecular Weight:
- 291.34
- MDL Number:
- MFCD06204513
- MOL File:
- 160809-38-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester | 130103 | 1.00g | $38 |
| Piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester | 130103 | 5.00g | $118 |
| Piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester | 130103 | 25.00g | $266 |
| Ethyl N-Cbz-piperidine-4-carboxylate 97% | E58758 | 1g | $25 |
| Ethyl N-Cbz-piperidine-4-carboxylate 97% | E58758 | 5g | $30 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
Ethyl N- Cbz -piperidine-4-carboxylate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 130103 | Piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester | 160809-38-1 | 1.00g | $38 | 2026-05-18 | Buy |
| Matrix Scientific | 130103 | Piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester | 160809-38-1 | 5.00g | $118 | 2026-05-18 | Buy |
| Matrix Scientific | 130103 | Piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester | 160809-38-1 | 25.00g | $266 | 2026-05-18 | Buy |
| Synthonix | E58758 | Ethyl N-Cbz-piperidine-4-carboxylate 97% | 160809-38-1 | 1g | $25 | 2026-05-06 | Buy |
| Synthonix | E58758 | Ethyl N-Cbz-piperidine-4-carboxylate 97% | 160809-38-1 | 5g | $30 | 2026-05-06 | Buy |
Ethyl N- Cbz -piperidine-4-carboxylate Chemical Properties,Uses,Production
Synthesis
1126-09-6
501-53-1
160809-38-1
The general procedure for the synthesis of ethyl 1-Cbz-piperidine-4-carboxylate from ethyl 4-piperidinecarboxylate and benzyl chloroformate was as follows: a solution of benzyl chloroformate (95 g, 0.56 mol) in dichloromethane (200 mL) was added slowly and dropwise to a stirred ethyl 4-piperidinecarboxylate (87 g, 0.55 mol) and sodium carbonate (60 g, 0.57 mol) mixture. The dropwise addition was controlled to be completed in 70 min, during which dichloromethane (200 mL) was added simultaneously. The reaction mixture was stirred continuously at room temperature for 2.5 days, followed by filtration through a Celte pad. The filtrate was concentrated under vacuum and the residue was partitioned between 2M aqueous hydrochloric acid and ether. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated. Finally, the residue was purified by silica gel column chromatography (eluent: ethyl acetate/isohexane) to afford the target product ethyl 1-Cbz-piperidine-4-carboxylate (152 g, 94% yield). The product was characterized by 1H NMR (360 MHz, CDCl3): δ 7.40-7.27 (5H, m), 5.12 (2H, s), 4.22-3.99 (2H, m), 4.40 (2H, q, J=7.4 Hz), 2.93 (2H, br t, J=11.6 Hz), 2.45 (2H, m), 1.97-1.81 (2H, m), 1.74-1.56 (2H, m), 1.25 (3H, t, J=7.4 Hz).
References
[1] Patent: WO2004/78750, 2004, A1. Location in patent: Page 64
[2] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 21
[3] Patent: WO2007/93603, 2007, A1. Location in patent: Page/Page column 15
[4] Patent: EP1522540, 2005, A1. Location in patent: Page/Page column 63
[5] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 67; 68
Ethyl N- Cbz -piperidine-4-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from Ethyl N- Cbz -piperidine-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
160809-38-1
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
-
- 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
160809-38-1
- $1.00
- 99%
- Career Henan Chemical Co
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