Coumarin 151
- CAS No.
- 53518-15-3
- Chemical Name:
- Coumarin 151
- Synonyms
- AFC;7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN;7-AMINO-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;Coumarin 490;AKOS B000459;COUMARIN 151;Coumarine151;BUTTPARK 20\02-79;Coumarin 490. Coumarin 15
- CBNumber:
- CB4277334
- Molecular Formula:
- C10H6F3NO2
- Molecular Weight:
- 229.16
- MDL Number:
- MFCD00006858
- MOL File:
- 53518-15-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 221-222 °C(lit.) |
|---|---|
| Boiling point | 314.6±42.0 °C(Predicted) |
| Density | 1.4096 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | Powder |
| pka | 1.12±0.20(Predicted) |
| color | Yellow |
| Water Solubility | Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water. |
| λmax | ≤207 nm |
| BRN | 4456797 |
| Major Application |
diagnostic assay manufacturing hematology histology |
| InChI | 1S/C10H6F3NO2/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4H,14H2 |
| InChIKey | JBNOVHJXQSHGRL-UHFFFAOYSA-N |
| SMILES | Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1 |
| CAS DataBase Reference | 53518-15-3(CAS DataBase Reference) |
| FDA UNII | P5QQ8K4F5Q |
| EPA Substance Registry System | 2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3) |
| UNSPSC Code | 12171500 |
| NACRES | NA.47 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29322090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Coumarin 151 price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 248924 | 7-Amino-4-(trifluoromethyl)coumarin ≥99% | 53518-15-3 | 250mg | $64.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 248924 | 7-Amino-4-(trifluoromethyl)coumarin ≥99% | 53518-15-3 | 1g | $147.7 | 2026-04-30 | Buy |
| TCI Chemical | A3747 | 7-Amino-4-(trifluoromethyl)coumarin min. 97.0 % | 53518-15-3 | 1G | $68 | 2026-04-30 | Buy |
| TCI Chemical | A3747 | 7-Amino-4-(trifluoromethyl)coumarin min. 97.0 % | 53518-15-3 | 5G | $204 | 2026-04-30 | Buy |
| Biosynth | FA74300 | 7-Amino-4-(trifluoromethyl)coumarin | 53518-15-3 | 0.5g | $250 | 2026-06-04 | Buy |
Coumarin 151 Chemical Properties,Uses,Production
Description
Coumarin 490 is a laser dye.
Chemical Properties
Coumarin 151 is yellow powder
Uses
Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.
Uses
7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.
Definition
ChEBI: 7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.
Purification Methods
Purify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.]
Coumarin 151 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
View Lastest Price from Coumarin 151 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | 7-Amino-4-(trifluoromethyl)coumarin
53518-15-3
|
97.91% | 10g | TargetMol Chemicals Inc. |
-
- 7-Amino-4-(trifluoromethyl)coumarin
53518-15-3
- $0.00
- 97.91%
- TargetMol Chemicals Inc.
