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Methyl 5-methoxysalicylate

Methyl 5-methoxysalicylate structure

CAS No.: 2905-82-0

Chemical Name:: Methyl 5-methoxysalicylate

Synonyms: RARECHEM AL BF 0042;Methyl 5-methoxysalicylate;Methyl5-Methoxysalicylate>Methyl 5-Methoxy Salicylicate;METHYL 2-HYDROXY-5-METHOXY-BENZOATE;5-METHOXYSALICYLIC ACID METHYL ESTER;2-HYDROXY-5-METHOXYBENZOIC ACID METHYL ESTER;Benzoic acid, 2-hydroxy-5-methoxy-, methyl ester;5-Methoxysalicylic Acid Methyl Ester Methyl 2-Hydroxy-5-methoxybenzoate 2-Hydroxy-5-methoxybenzoic Acid Methyl Ester

CBNumber:: CB6461876

Molecular Formula:: C9H10O4

Molecular Weight:: 182.17

MDL Number:: MFCD00017185

MOL File:: 2905-82-0.mol

MSDS File:: SDS

Last updated:2026-09-12 18:54:16

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Methyl 5-methoxysalicylate Properties

Boiling point	235-240 °C (lit.)
Density	1.223 g/mL at 25 °C (lit.)
refractive index	n20/D 1.544(lit.)
Flash point	>230 °F
storage temp.	Storage temp. 2-8°C
pka	10.24±0.18(Predicted)
form	clear liquid
color	Colorless to Light yellow
λmax	334nm(CH3CN)(lit.)
InChI	1S/C9H10O4/c1-12-6-3-4-8(10)7(5-6)9(11)13-2/h3-5,10H,1-2H3
InChIKey	DFNBGZODMHWKKK-UHFFFAOYSA-N
SMILES	COC(=O)c1cc(OC)ccc1O
CAS DataBase Reference	2905-82-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

2918999090

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
0		0

Methyl 5-methoxysalicylate price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	456683	Methyl 5-methoxysalicylate 98%	2905-82-0	5ml	$89.1	2023-01-07	Buy
Sigma-Aldrich	456683	Methyl 5-methoxysalicylate 98%	2905-82-0	25ml	$283	2023-01-07	Buy
TCI Chemical	M2127	Methyl 5-Methoxysalicylate >98.0%(GC)	2905-82-0	5g	$41	2026-04-30	Buy
TCI Chemical	M2127	Methyl 5-Methoxysalicylate >98.0%(GC)	2905-82-0	25g	$159	2026-04-30	Buy
Biosynth	FM71188	Methyl 2-hydroxy-5-methoxybenzoate	2905-82-0	100g	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
456683	5ml	$89.1	Buy
456683	25ml	$283	Buy
M2127	5g	$41	Buy
M2127	25g	$159	Buy
FM71188	100g	$150	Buy

Methyl 5-methoxysalicylate Chemical Properties,Uses,Production

Synthesis

2612-02-4

74-88-4

2905-82-0

To a solution of N,N-dimethylformamide (80 mL) of 2-hydroxy-5-methoxybenzoic acid (6.0 g, 35.68 mmol) was sequentially added sodium bicarbonate (3.15 g, 37.46 mmol) and iodomethane (2.33 mL, 37.46 mmol). The reaction mixture was stirred at 80 °C for 3 hours. Upon completion of the reaction, ice water was added to the mixture, followed by extraction with ether. The combined organic phases were washed sequentially with water and saturated brine and then dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the brown oily product methyl 2-hydroxy-5-methoxybenzoate (5.38 g, 82.8% yield).

References

[1] Patent: US2004/242615, 2004, A1. Location in patent: Page/Page column 13
[2] ChemMedChem, 2016, vol. 11, # 1, p. 108 - 118
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 2, p. 334 - 343
[4] Organic Letters, 2018, vol. 20, # 5, p. 1316 - 1319

Methyl 5-methoxysalicylate Preparation Products And Raw materials

Raw materials

5-Methoxysalicylic acid Iodomethane N,N-Dimethylformamide Sodium bicarbonate

Preparation Products

5-Methoxysalicylamide

Methyl 5-methoxysalicylate Suppliers

Global( 133)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Shanghai civi chemical technology co.,Ltd	86-21-34053660	sale@labgogo.com	China	9853	52
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
Accela ChemBio Co.,Ltd.	64
Shanghai Longsheng chemical Co.,Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Shandong Xiya Chemical Co., Ltd	57
Shanghai civi chemical technology co.,Ltd	52
Shanghai Topbiochem Technology Co., Ltd	58

View Lastest Price from Methyl 5-methoxysalicylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-26	METHYL 5-METHOXYSALICYLATE 2905-82-0	$1.00	1KG	99%	100KG	Career Henan Chemical Co

METHYL 5-METHOXYSALICYLATE
2905-82-0
$1.00
99%
Career Henan Chemical Co

Methyl 5-methoxysalicylate Spectrum

METHYL 5-METHOXYSALICYLATE(2905-82-0)¹HNMR METHYL 5-METHOXYSALICYLATE(2905-82-0)IR

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