- (Z)-Guggulsterone
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2026-09-11
- CAS:39025-23-5
- Min. Order: 20MG
- Purity: 99% HPLC
- Supply Ability: 100KG
- (Z)-Guggulsterone
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- $91.00
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2026-07-27
- CAS:39025-23-5
- Purity: 98.93%
- Supply Ability: 10g
- (E)-Guggulsterone
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- $1.00
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2019-07-06
- CAS:39025-23-5
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100KG
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| | Z-Guggulsterone Basic information |
| Product Name: | Z-Guggulsterone | | Synonyms: | 4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE;GUGULSTERONE;GUGGULESTERONE Z;GUGGULSTERONE Z;GUGGULSTERONE (Z FORM);CIS-4,17(20)-PREGNADIENE-3,16-DIONE;CIS GUGGULSTERONE;PREGNA-4,17(20)-DIENE-3,16-DIONE | | CAS: | 39025-23-5 | | MF: | C21H28O2 | | MW: | 312.45 | | EINECS: | | | Product Categories: | | | Mol File: | 39025-23-5.mol |  |
| | Z-Guggulsterone Chemical Properties |
| Melting point | 188-190° | | alpha | D26 -61° (c = 1 in chloroform) | | Boiling point | 463.3±45.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 5 mg/mL | | form | powder | | color | light yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | Major Application | forensics and toxicology
veterinary | | InChI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1 | | InChIKey | WDXRGPWQVHZTQJ-OSJVMJFVSA-N | | SMILES | C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)/C(=C/C)/C(=O)C3)CC2 | | LogP | 3.650 (est) |
| Hazard Codes | Xi | | Risk Statements | 37-38 | | Safety Statements | 36 | | WGK Germany | 3 | | HS Code | 2914299000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | STOT SE 3 |
| | Z-Guggulsterone Usage And Synthesis |
| Description | Guggulsterone-(Z) (39025-23-5) is a natural steroid fromCommiphora mukulextract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1Attenuates astrocyte-mediated neuroinflammation.2 Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4 | | Uses | Z-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent. | | Uses | (Z)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent. | | Definition | ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen. | | Biological Activity | Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signalling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo . More active isomer of Guggulsterone (Pregna-4,17(20)-diene-3,16-dione ). | | Biochem/physiol Actions | (Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator. | | storage | Store at RT | | References | [1] NANCY L. URIZAR. A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR[J]. Science, 2002, 296 5573. DOI:10.1126/science.1072891
[2] TIANLONG LIU. Z-Guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway[J]. Journal of Neurochemistry, 2018, 147 6: 803-815. DOI:10.1111/jnc.14583
[3] ANDREW AGBAY. Guggulsterone-releasing microspheres direct the differentiation of human induced pluripotent stem cells into neural phenotypes.[J]. Biomedical materials (Bristol, England), 2018, 13 3: 034104. DOI:10.1088/1748-605x/aaaa77
[4] FENG-GUO LIU. Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway.[J]. International Journal of Neuropsychopharmacology, 2017, 20 6: 485-497. DOI:10.1093/ijnp/pyx009 |
| | Z-Guggulsterone Preparation Products And Raw materials |
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