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D-1-N-Boc-prolinamide

D-1-N-Boc-prolinamide structure

CAS No.: 35150-07-3

Chemical Name:: D-1-N-Boc-prolinamide

Synonyms: BOC-PRO-NH2;1-Boc-D-proL;BOC-L-PRO-NH2;BOC-PYRD(2)-NH2;Boc-Proliniamide;BOC-L-PROLINAMIDE;Boc-D-Prolinamide;N-Boc-Prolinamide;BOC-D-PROLINEAMIDE;BOC-L-PROLINE AMIDE

CBNumber:: CB8284602

Molecular Formula:: C10H18N2O3

Molecular Weight:: 214.26

MDL Number:: MFCD00190827

MOL File:: 35150-07-3.mol

MSDS File:: SDS

Last updated:2025-09-25 19:11:34

Product description	Number	Pack Size	Price
1-Boc-L-prolinamide 97%	661198	1g	$69.5
1-Boc-L-prolinamide 97%	661198	5g	$323
N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N)	B3756	1g	$26
N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N)	B3756	5g	$34
1-Boc-L-Prolinamide	B664100	100mg	$50
More product size

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D-1-N-Boc-prolinamide Properties

Melting point	104-108 °C
Boiling point	370.1±31.0 °C(Predicted)
Density	1.155±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	15.97±0.20(Predicted)
form	powder to crystal
color	White to Almost white
optical activity	Consistent with structure
CAS DataBase Reference	35150-07-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312a-P330-P501a

Hazard Codes

Risk Statements

Safety Statements

24/25

WGK Germany

HS Code

2933.99.9701

NFPA 704

	1
2		0

D-1-N-Boc-prolinamide price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	661198	1-Boc-L-prolinamide 97%	35150-07-3	1g	$69.5	2023-06-20	Buy
Sigma-Aldrich	661198	1-Boc-L-prolinamide 97%	35150-07-3	5g	$323	2023-06-20	Buy
TCI Chemical	B3756	N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N)	35150-07-3	1g	$26	2025-07-31	Buy
TCI Chemical	B3756	N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N)	35150-07-3	5g	$34	2025-07-31	Buy
TRC	B664100	1-Boc-L-Prolinamide	35150-07-3	100mg	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
661198	1g	$69.5	Buy
661198	5g	$323	Buy
B3756	1g	$26	Buy
B3756	5g	$34	Buy
B664100	100mg	$50	Buy

D-1-N-Boc-prolinamide Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

1-Boc-L-prolinamide is a reagent that is used in the preparation of thiazole amide peptidomimetics as erratum inhibitor apoptosis protein antagonist.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

15761-39-4

35150-07-3

GENERAL METHOD: BOC-L-proline (1.00 g, 4.65 mmol), di-tert-butyl dicarbonate (1.52 g, 6.97 mmol), ammonium bicarbonate (0.55 g, 6.97 mmol), and pyridine (1.0 mL) were dissolved in dioxane (20 mL), and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, the product was extracted with dichloromethane, the organic phase was washed sequentially with 1 M hydrochloric acid and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the concentrate was added n-hexane (100 mL) and sonication prompted the product to precipitate as a white solid to afford N-tert-butoxycarbonyl-L-prolinamide (0.85 g, 85% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.37-4.34 (m, 1H), 3.47-3.36 (m, 2H), 2.07-1.85 (m, 4H), 1.49 (s, 9H). Mass spectrum (ESI) m/z 215 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 6, p. 1719 - 1729
[2] Canadian Journal of Chemistry, 2007, vol. 85, # 2, p. 85 - 95
[3] Journal of Agricultural and Food Chemistry, 2012, vol. 60, # 35, p. 8544 - 8551
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 228 - 247
[5] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 23, p. 7418 - 7429

D-1-N-Boc-prolinamide synthesis

Synthesis of D-1-N-Boc-prolinamide from BOC-L-Proline

D-1-N-Boc-prolinamide Preparation Products And Raw materials

Raw materials

BOC-PRO-ONP BOC-PRO-OSU D-1-N-BOC-PROLINAMIDE L-Prolinamide Boc-L-Proline-methyl ester

L-Proline Di-tert-butyl dicarbonate BOC-L-Proline 1,4-Dioxane Ammonium bicarbonate

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Preparation Products

D-1-N-Boc-prolinamide Suppliers

Global( 303)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9080	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Shaanxi Didu New Materials Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Chembon Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58

View Lastest Price from D-1-N-Boc-prolinamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-25	D-1-N-Boc-prolinamide 35150-07-3	US $1.50 / g	1g	99.0% Min	100 Tons	Shaanxi Didu New Materials Co. Ltd
	2019-07-06	D-1-N-Boc-prolinamide 35150-07-3	US $100.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

D-1-N-Boc-prolinamide
35150-07-3
US $1.50 / g
99.0% Min
Shaanxi Didu New Materials Co. Ltd

D-1-N-Boc-prolinamide
35150-07-3
US $100.00 / KG
99%
Career Henan Chemical Co

D-1-N-Boc-prolinamide Spectrum

D-1-N-Boc-prolinamide(35150-07-3)¹HNMR

35150-07-3(D-1-N-Boc-prolinamide)Related Search:

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tert-Butanol tert-Butyl carbazate Cyhalofop-butyl Buprofezin L-Prolinamide

Polyvinylpyrrolidone Isobutyl chloroformate BOC-L-Proline RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE CHLOROAC-PRO-OH

(S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Butyl acrylate (S)-1-N-Boc-2-methylpiperazine

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BOC-L-PROLINAMIDE BOC-L-PRO-NH2 BOC-L-PROLINE AMIDE BOC-PYRD(2)-NH2 BOC-PRO-NH2 L-1-N-Bocprolidinamid tert-butyl (2S)-2-carbamoylpyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)- N-Boc-L-Prolinamide (S)-N-BOC-Pyrrolidine-2-carboxamide Vildagliptin Impurity 16 (S)-Boc-pyrrolidine-2-carboxylic acid amide Boc-L-proline amide≥ 99% (HPLC) N-Boc-L-prolinamide,99%e.e. tert-Butyl (S)-2-carbamoylpyrrolidine-1-carboxylate (Tert-Butoxy)Carbonyl Pro-NH2 L-1-N-BOC-PROLIDINAMIDE (L)-1-N-BOC-PROLINAMIDE Boc-D-Prolinamide D-1-N-Boc-prolinamide tert-Butyl (2R)-2-carbamoylpyrrolidine-1-carboxylate 1-BOC-L-PROLINAMIDE (S)-2-(AMINOCARBONYL)-1-PYRROLIDINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER (S)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE AMIDE N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE AMIDE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE AMIDE N-(TERT-BUTOXYCARBONYL)PROLINE AMIDE N-TERT-BUTOXYCARBONYL-L-PROLINE AMIDE DL-1-BOC-PROLINAMIDE N-alpha-t-Butyloxycarbonyl-D-proline amide N-ALPHA-BOC-L-PROLINEAMIDE BOC-D-PROLINEAMIDE N-(tert-Butoxycarbonyl)proline amide, (S)-2-(Aminocarbonyl)-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester (R)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate N-(tert-Butoxycarbonyl)-L-prolinaMide Boc-Proliniamide N-(tert-Butoxycarbonyl)-L-prolinamide > 1-Boc-D-proL (S)-2-Carbamoyl-1-pyrrolidinecarboxylic Acid tert-Butyl Ester tert-Butyl (S)-2-Carbamoyl-1-pyrrolidinecarboxylate D-1-N-Boc-prolinamide USP/EP/BP N-Boc-Prolinamide BOC-L-Prolinamide extrapure, 98% 1,1-Dimethylethyl (2S)-2-(aminocarbonyl)-1-pyrrolidinecarboxylate 1-Boc-L-prolinamide 35150-07-3 C10H18N2O3 Amino Acid Derivatives Amino Acids Pyrrole&Pyrrolidine&Pyrroline