Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Structure
2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole structure
CAS No.
252212-58-1
Chemical Name:
2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole
Synonyms
GAPDH-IN-1;GAPDH inhibitor compound F8;2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole;1,3,4-Oxadiazole, 2,5-bis[3-(2-oxiranylmethoxy)phenyl]-
CBNumber:
CB44257510
Molecular Formula:
C20H18N2O5
Molecular Weight:
366.37
MDL Number:
MOL File:
252212-58-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:18
Request For Quotation

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Properties

Boiling point 584.4±58.0 °C(Predicted)
Density 1.318±0.06 g/cm3(Predicted)
solubility Acetonitrile: Slightly soluble: 0.1-1 mg/ml
pka -5.20±0.45(Predicted)

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 42090 GAPDH Inhibitor Compound F8 ≥95% 252212-58-1 1mg $39 2026-04-30 Buy
Cayman Chemical 42090 GAPDH Inhibitor Compound F8 ≥95% 252212-58-1 5mg $174 2026-04-30 Buy
ChemScene CS-1244267 GAPDH-IN-1 98.1% 252212-58-1 1mg $115 2026-06-04 Buy
ChemScene CS-1244267 GAPDH-IN-1 98.1% 252212-58-1 5mg $433 2026-06-04 Buy
Axon Medchem Axon3612 GAPDH inhibitor compound F8 10mg $132 2026-05-19 Buy
Product number Packaging Price Buy
42090 1mg $39 Buy
42090 5mg $174 Buy
CS-1244267 1mg $115 Buy
CS-1244267 5mg $433 Buy
Axon3612 10mg $132 Buy

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Chemical Properties,Uses,Production

Uses

GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine[1].

References

[1] Jung Y, et al. Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe. ACS Chem Biol. 2022 Feb 18;17(2):340-347. DOI:10.1021/acschembio.1c00824

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol 58

252212-58-1(2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole)Related Search:

4-Quinolinamine, 7-iodo-N-(3,4,5-trimethoxyphenyl)- Glutaminase C-IN-1 N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide MAGL-IN-1
Calcitriol

1of2

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole 1,3,4-Oxadiazole, 2,5-bis[3-(2-oxiranylmethoxy)phenyl]- GAPDH inhibitor compound F8 GAPDH-IN-1 252212-58-1