4-(1H-Imidazol-1-yl)benzonitrile
- CAS No.
- 25372-03-6
- Chemical Name:
- 4-(1H-Imidazol-1-yl)benzonitrile
- Synonyms
- 140179;BUTTPARK 96\50-66;1-(4-CYANOPHENYL)IMIDAZOLE;4-(1-IMIDAZOLYL)BENZONITRILE;4-IMIDAZOL-1-YL-BENZONITRILE;1-(4-Cyanophenyl)imidazole >4-(1H-Imidazol-1-yl)benzonitrile;Benzonitrile, 4-(1H-imidazol-1-yl)-;4-(1H-Imidazol-1-yl)benzonitrile,97%;4-(1H-IMIDAZOL-1-YL)BENZENECARBONITRILE
- CBNumber:
- CB4727293
- Molecular Formula:
- C10H7N3
- Molecular Weight:
- 169.18
- MDL Number:
- MFCD00127147
- MOL File:
- 25372-03-6.mol
- MSDS File:
- SDS
| Melting point | 151-153 °C |
|---|---|
| Boiling point | 358.1±25.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.85±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| CAS DataBase Reference | 25372-03-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36/37 | |||||||||
| RIDADR | 3276 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933299090 | |||||||||
| NFPA 704 |
|
4-(1H-Imidazol-1-yl)benzonitrile price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2045 | 1-(4-Cyanophenyl)imidazole >98.0%(GC) | 25372-03-6 | 5g | $225 | 2026-04-30 | Buy |
| Activate Scientific | AS35881 | 4-(1H-Imidazol-1-yl)benzonitrile 98% | 25372-03-6 | 5g | $29 | 2026-06-04 | Buy |
| Activate Scientific | AS35881 | 4-(1H-Imidazol-1-yl)benzonitrile 98% | 25372-03-6 | 25g | $322 | 2026-06-04 | Buy |
| Matrix Scientific | 043188 | 4-(1H-Imidazol-1-yl)benzenecarbonitrile | 25372-03-6 | 500.00mg | $118 | 2026-05-18 | Buy |
| Matrix Scientific | 043188 | 4-(1H-Imidazol-1-yl)benzenecarbonitrile | 25372-03-6 | 1.00g | $151 | 2026-05-18 | Buy |
4-(1H-Imidazol-1-yl)benzonitrile Chemical Properties, Uses, Production
Chemical Properties
off-white crystalline powder
Uses
4-(1H-Imidazol-1-yl)benzonitrile is a nitroimidazoles with mutagenic properties. A useful research chemical.
Synthesis
288-32-4
1194-02-1
25372-03-6
Under nitrogen protection, 1500 mL of anhydrous dimethylformamide (DMF) was added to a 1000 mL four-necked flask, followed by 72.67 g (0.6 mol) of p-fluorobenzonitrile and 61.2 g (0.9 mol) of imidazole sequentially. Finally, 21.6 g (0.9 mol) of sodium hydride was slowly added. The reaction mixture was heated to 100 °C, kept at this temperature and stirred for 4 hours, followed by continued stirring at room temperature overnight. Upon completion of the reaction, the mixture was poured into water and extracted with dichloromethane several times. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated on a rotary evaporator. Finally, the product was dried under reduced pressure at 60 °C to give 94 g of 4-(imidazol-1-yl)benzonitrile in 93% yield of the theoretical value. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ= 7.27 (s, 1H); 7.35 (s, 1H); 7.54 (d, J = 8.8 Hz, 2H); 7.81 (d, J = 8.8 Hz, 2H); 7.95 (s, 1H).
References
[1] Synthetic Communications, 2008, vol. 38, # 4, p. 626 - 636
[2] Patent: WO2006/56418, 2006, A2. Location in patent: Page/Page column 57
[3] Patent: US2009/18330, 2009, A1. Location in patent: Page/Page column 14
[4] Advanced Synthesis and Catalysis, 2007, vol. 349, # 11-12, p. 1938 - 1942
[5] Monatshefte fur Chemie, 2004, vol. 135, # 4, p. 419 - 423
4-(1H-Imidazol-1-yl)benzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 4-(1H-Imidazol-1-yl)benzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 4-(1H-IMIDAZOL-1-YL)BENZONITRILE
25372-03-6
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- 4-(1H-IMIDAZOL-1-YL)BENZONITRILE
25372-03-6
- $1.00
- 99.0%
- Career Henan Chemical Co
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