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Boc-Tic-OH

Boc-Tic-OH structure

CAS No.: 78879-20-6

Chemical Name:: Boc-Tic-OH

Synonyms: (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;Boc-Tic;BOC-L-TIC;Boc-Tic-OH;BOC-L-TIC-OH;Boc-Tic-OH, >=98%;RARECHEM BK PT 0083;BOC-TIC-OH USP/EP/BP;Boc-Tic-OH >=97.0% (TLC);(Tert-Butoxy)Carbonyl Tic-OH

CBNumber:: CB4750051

Molecular Formula:: C15H19NO4

Molecular Weight:: 277.32

MDL Number:: MFCD00143845

MOL File:: 78879-20-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:57

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Boc-Tic-OH Properties

Melting point	125-126.5 °C
Boiling point	420.18°C (rough estimate)
Density	1.1311 (rough estimate)
refractive index	1.5080 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	soluble in Methanol
form	Solid
pka	3.88±0.20(Predicted)
color	White to off-white
optical activity	[α]20/D +19.0±1.5°, c = 0.7% in methanol
BRN	4297114
Major Application	peptide synthesis
InChI	1S/C15H19NO4/c1-15(2,3)20-14(19)16-9-11-7-5-4-6-10(11)8-12(16)13(17)18/h4-7,12H,8-9H2,1-3H3,(H,17,18)/t12-/m0/s1
InChIKey	HFPVZPNLMJDJFB-LBPRGKRZSA-N
SMILES	CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(O)=O
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

22-24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29334900

Storage Class

13 - Non Combustible Solids

NFPA 704

	0
0		0

Boc-Tic-OH price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B4501	(S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid >98.0%(HPLC)(T)	78879-20-6	5g	$84	2026-04-30	Buy
TCI Chemical	B4501	(S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid >98.0%(HPLC)(T)	78879-20-6	25g	$249	2026-04-30	Buy
Usbiological	266515	Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Asreported	78879-20-6	2g	$333	2026-06-03	Buy
Usbiological	266515	Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Asreported	78879-20-6	5g	$516	2026-06-03	Buy
Usbiological	266515	Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Asreported	78879-20-6	10g	$706	2026-06-03	Buy

Product number	Packaging	Price	Buy
B4501	5g	$84	Buy
B4501	25g	$249	Buy
266515	2g	$333	Buy
266515	5g	$516	Buy
266515	10g	$706	Buy

Boc-Tic-OH Chemical Properties, Uses, Production

Chemical Properties

white to light beige powder

Uses

Boc-Tic-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Synthesis

24424-99-5

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

74163-81-8

115962-35-1

The general procedure for the synthesis of (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid from di-tert-butyl dicarbonate and (S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was as follows: (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (50.0 g, 282 mmol) was suspended in 1,4-dioxane ( 1000 mL) and water (500 mL) in a solvent mixture with vigorous stirring. Sodium bicarbonate (47.4 g, 564 mmol) and di-tert-butyl dicarbonate (67.7 g, 310 mmol) were subsequently added and the reaction mixture was stirred continuously at room temperature for 6 days. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was dissolved in water (2000 mL). A 30% w/v aqueous solution of sodium bisulfate monohydrate (300 mL) was added and extracted with chloroform (3 x 1000 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the target product (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (90.0 g, quantitative yield) as a thick slurry.Results of LCMS analysis: retention time 3.64 min; mass spectrometry data m/z 178.1 [M-Boc + 2H]+ ; m/ z 276.1 [M-H]-.

References

[1] Patent: WO2017/153513, 2017, A1. Location in patent: Page/Page column 78
[2] Patent: WO2017/153515, 2017, A1. Location in patent: Page/Page column 62
[3] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 44; 47
[4] Patent: WO2017/153519, 2017, A1. Location in patent: Page/Page column 56; 59
[5] Tetrahedron Letters, 2001, vol. 42, # 43, p. 7559 - 7561

Boc-Tic-OH Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Water 1,4-Dioxane Sodium bicarbonate

Preparation Products

Boc-Tic-OH Suppliers

Global Suppliers ( 233)

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Copiore Chemical Co., Ltd.	17300981287 13757145729	sales@copiore.com	China	291	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai HC Biotech Co., Ltd	021-20227858	sale@hcbiotech.com.cn	China	1173	55
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Suzhou haiyu Biochem Industrial Co., LTD	512-68097639 18013585858	744942877@qq.com	China	915	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60

Supplier	Advantage
Hangzhou Copiore Chemical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Shanghai HC Biotech Co., Ltd	55
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Suzhou haiyu Biochem Industrial Co., LTD	62
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60

View Latest Price from Boc-Tic-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-17	Boc-Tic-OH 78879-20-6		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
	2019-07-06	BOC-TIC-OH 78879-20-6	$1.00	1kg	98%	100KG	Career Henan Chemical Co

Boc-Tic-OH
78879-20-6
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

BOC-TIC-OH
78879-20-6
$1.00
98%
Career Henan Chemical Co

Boc-Tic-OH Spectrum

BOC-TIC-OH(78879-20-6)¹HNMR

78879-20-6 (Boc-Tic-OH) Related Search:

Boc-L-serine methyl ester Boc-L-Tyrosine methyl ester N-Boc-L-tert-Leucine N-Boc-L-valine Boc-L-Threonine

BOC-L-Tyrosine O-(2-Azido-4,6-O-benzylidene-2-deoxy-alpha-D-galactopyranosyl)-N-Fmoc-L-serine tert-Butyl Ester Boc-L-tyrosine ethyl ester Boc-L-Tyr-ol Boc-Val-NH2

Boc-Ser-OH Boc-Trp-OMe 1,2,3,4-Tetrahydroisoquinoline H-Tic-OH 5,6,7,8-Tetrahydroisoquinoline

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

1of4

Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid98+% (S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic A cid,99%e.e. (Tert-Butoxy)Carbonyl Tic-OH N-Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, 98% N-T-BUTOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (S)-()-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID (S)-(+)-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID (S)-N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID RARECHEM BK PT 0083 (S)-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (S)-(+)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID (S)-3,4-DIHYDRO-1H-ISOQUINOLINE-2,3-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER BOC-1,2,3,4-L-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BOC-(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID Boc-Tic-OH >=97.0% (TLC) Boc-Tic-OH, >=98% (3S)-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-3,4-dihydro-1H-isoquinoline-3-carboxylate N-tert-Butoxycarbonyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid BOC-L-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BOC-L-TIC BOC-L-TIC-OH BOC-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BOC-(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID 2,3(1H)-ISOQUINOLINEDICARBOXYLIC ACID, 3,4-DIHYDRO-,2-(1,1-DIMETHYLETHYL) ESTER, (3S)- (3S)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (S)-(+)-2-(Tertutoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected N-T-BUTYLOXYCARBONYL-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID N-BOC-L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid,99% Boc-(S)-1,2,3,4-tetrahydroisoquinoline-line-3-carboxylic acid N-1-BOC-L-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID N-1-T-BOC-L-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID N-ALPHA-T-BOC-L-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID N-BOC-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID N-TERT-BUTYLOXYCARBONYL-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID N-Boc-L-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli N-T-boc-L-1,2,3,4-tetrahydroiso-*quinoline-3-carb Boc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic (3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected Boc-L-Tetrahydroisoquinoline-3-COOH Boc-Tic-OH(Boc-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid) N-Boc-L-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli acid Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylicaci BOC-TIC-OH USP/EP/BP Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid, 98%mim (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Boc-Tic Boc-Tic-OH 78879-20-6 78879-20-7 78879-20-8 78879-20-9 C15H19NO4 Peptide Synthesis Others Unnatural Amino Acid Derivatives