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4-Bromopyridine-2-carbaldehyde

4-Bromopyridine-2-carbaldehyde structure

CAS No.: 131747-63-2

Chemical Name:: 4-Bromopyridine-2-carbaldehyde

Synonyms: 4-BROMOPICOLINALDEHYDE;4-Bromopyridine-2-carbaL;4-BROMOPYRIDINE-2-CARBALDEHYD;4-broMopyridin-2-carbaldehyde;4-Bromopyridine-2-carbaldehyde;4-BROMO-2-PYRIDINECARBALDEHYDE;2-Pyridinecarboxaldehyde,4-broMo;4-broMo-2-pyridinecarboxaldehyde;4-Bromopyridine 2-carboxaldehyde;4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2

CBNumber:: CB4789684

Molecular Formula:: C6H4BrNO

Molecular Weight:: 186.01

MDL Number:: MFCD08690697

MOL File:: 131747-63-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:58

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4-Bromopyridine-2-carbaldehyde Properties

Boiling point	244.0±20.0 °C(Predicted)
Density	1.683±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), DMSO (Sparingly)
form	solid
pka	1.78±0.10(Predicted)
color	Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2933399990

4-Bromopyridine-2-carbaldehyde price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-B686135-2.5G	4-Bromopyridine-2-carboxaldehyde	131747-63-2	2.5g	$390	2026-06-03	Buy
TRC	TRC-B686135-1G	4-Bromopyridine-2-carboxaldehyde	131747-63-2	1g	$202	2026-06-03	Buy
TRC	TRC-B686135-10G	4-Bromopyridine-2-carboxaldehyde	131747-63-2	10g	$968	2026-06-03	Buy
Activate Scientific	AS3260	4-Bromopicolinaldehyde 97%	131747-63-2	1g	$43	2026-06-04	Buy
Activate Scientific	AS3260	4-Bromopicolinaldehyde 97%	131747-63-2	5g	$151	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-B686135-2.5G	2.5g	$390	Buy
TRC-B686135-1G	1g	$202	Buy
TRC-B686135-10G	10g	$968	Buy
AS3260	1g	$43	Buy
AS3260	5g	$151	Buy

4-Bromopyridine-2-carbaldehyde Chemical Properties, Uses, Production

Uses

4-Bromopyridine-2-carboxaldehyde is a reagent used to synthesize Curcumin (C838500) analogues. It can also be used to prepare 1,4-dihydropyridine calcium antagonists.

Synthesis

131747-45-0

131747-63-2

General procedure for the synthesis of 4-bromopyridine-2-carboxaldehyde from 2-hydroxymethyl-4-bromopyridine: 3L of dichloromethane (DCM) was added to a 5L three-necked flask under nitrogen protection, and cooled to -60 °C. During the cooling process, 240 g of oxalyl chloride was added slowly and dropwise. Maintaining the reaction temperature at -60 °C, 295.6 g of dimethyl sulfoxide (DMSO) was added dropwise to the reaction system and held for 30 min after the dropwise addition. Subsequently, 237.5 g of 2-hydroxymethyl-4-bromopyridine (Cpd 3) was slowly added dropwise at -60 °C and the reaction was continued at -65 °C for 1 hour. At this temperature, 3.5 equivalents of triethylamine (TEA) was added, and the reaction solution was allowed to stand before the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the target product 4-bromopyridine-2-carboxaldehyde (Compound 4) was purified by column chromatography to give 177.2 g in 75% yield.

References

[1] Patent: US2010/125082, 2010, A1. Location in patent: Page/Page column 24
[2] Tetrahedron, 1997, vol. 53, # 24, p. 8257 - 8268
[3] Patent: CN108516953, 2018, A. Location in patent: Paragraph 0067-0068; 0074-0075; 0076-0083
[4] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[5] MedChemComm, 2015, vol. 6, # 7, p. 1252 - 1259

4-Bromopyridine-2-carbaldehyde synthesis

Synthesis of 4-Bromopyridine-2-carbaldehyde from 4-Bromo-2-pyridinemethanol

4-Bromopyridine-2-carbaldehyde Preparation Products And Raw materials

Raw materials

(4-Bromopyridin-2-yl)methyl acetate 4-Nitropicolinaldehyde CHEMPACIFIC 38139 4-Bromo-N-methoxy-N-methylpicolinamide 4-bromo-2-methylpyridine 1-oxide

4-Bromo-2-pyridinemethanol 2-Picoline-N-oxide 2-Methyl-4-nitropyridine 4-Nitro-2-picoline N-oxide Phenyl chloroformate

4-Bromopyridine-2-carboxylic acid

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Preparation Products

4-Bromo-2-methylpyridine

4-Bromopyridine-2-carbaldehyde Suppliers

Global Suppliers ( 184)

Supplier	Tel	Email	Country	ProdList	Advantage
PharmaBlock Sciences (Nanjing),Inc.	025-86918202 4000255188	sales@pharmablock.com	China	5000	55
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Boc Chemical Co.,Ltd	021-34975603-808 18721111801	sales@bocpharma.com	China	991	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65

Supplier	Advantage
PharmaBlock Sciences (Nanjing),Inc.	55
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64
Shanghai Boc Chemical Co.,Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Ennopharm Co., Ltd.	65

View Latest Price from 4-Bromopyridine-2-carbaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2020-05-13	4-Bromopicolinaldehyde 131747-63-2		1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd
2019-12-23	4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2	$1.00	1KG	99%	200kg	Career Henan Chemical Co

4-BROMOPYRIDINE-2-CARBALDEHYDE
131747-63-2
$1.10
99.00%
Dideu Industries Group Limited

4-Bromopicolinaldehyde
131747-63-2
99.0%
Shaanxi Dideu Medichem Co. Ltd

4-BROMOPYRIDINE-2-CARBALDEHYDE
131747-63-2
$1.00
99%
Career Henan Chemical Co

4-Bromopyridine-2-carbaldehyde Spectrum

4-BROMOPYRIDINE-2-CARBALDEHYDE(131747-63-2)¹HNMR

131747-63-2 (4-Bromopyridine-2-carbaldehyde) Related Search:

4-Bromopyridine-2,6-dicarboxylic acid 4-Bromo-pyridine-2,6-dicarboxylic acid diamide 4-Bromo-pyridine-2-carboxylic acid methyl ester 4-Bromopyridine-2-carbaldehyde 4-Bromopyridine-2-carboxylic acid

4-Bromo-pyridine-2-carboxylic acid ethyl ester 4-Bromoqinoline-2-carboxaldehyde 2-Amino-4-bromo-6-carboxypyridine methyl ester Dimethyl 2-bromo-2,6-pyridinedicarboxylate 4-Bromo-2,6-diformylpyridine

Diethyl 4-bromopyridine-2,6-dicarboxylate 4-Bromo-6-methyl-pyridine-2-carbaldehyde 4-Bromo-6-methyl-pyridine-2-carboxylic acid 4-Bromoquinoline-2-carboxylic acid 1-(4-Bromopyridin-2-yl)-2,2,2-trifluoroethanone

4-Bromo-6-methyl-pyridine-2-carboxylic acid methyl ester 4-Bromo-6-methylpyridine-2-carboxamide 4-Bromo-3-methyl-pyridine-2-carbaldehyde

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4-Bromopyridine 2-carboxaldehyde 4-broMopyridin-2-carbaldehyde 4-broMo-2-pyridinecarboxaldehyde 2-Pyridinecarboxaldehyde,4-broMo 4-Bromopyridine-2-carbaL 4-BROMO-2-PYRIDINECARBALDEHYDE 4-BROMOPYRIDINE-2-CARBALDEHYDE ISO 9001：2015 REACH 4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2 4-BROMOPYRIDINE-2-CARBALDEHYD 4-BROMOPICOLINALDEHYDE 4-Bromopyridine-2-carbaldehyde 131747-63-2 Pyridines Heterocycle-Pyridine series