2-Picoline-N-oxide
- CAS No.
- 931-19-1
- Chemical Name:
- 2-Picoline-N-oxide
- Synonyms
- 2-METHYLPYRIDINE 1-OXIDE;2-picoline-oxide;-Picoline N-oxide;a-Picoline N-oxide;a-Picoline 1-oxide;2-PICOLINE-N-OXIDE;2-Picoline, 1-oxide;Alfa picoline oxide;2-Picoline-N-oxide,98%;alpha-Picoline 1-oxide
- CBNumber:
- CB7748015
- Molecular Formula:
- C6H7NO
- Molecular Weight:
- 109.13
- MDL Number:
- MFCD00006199
- MOL File:
- 931-19-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 41-45 °C(lit.) |
|---|---|
| Boiling point | 259-261 °C |
| Density | 1.1143 (rough estimate) |
| refractive index | 1.5444 (estimate) |
| Flash point | >230 °F |
| storage temp. | RT, stored under nitrogen |
| pka | pK1:1.029(+1) (25°C) |
| form | powder to lump to clear liquid |
| color | White or Colorless to Light yellow |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 106916 |
| InChI | InChI=1S/C6H7NO/c1-6-4-2-3-5-7(6)8/h2-5H,1H3 |
| InChIKey | CFZKDDTWZYUZKS-UHFFFAOYSA-N |
| SMILES | C1(C)[N+]([O-])=CC=CC=1 |
| CAS DataBase Reference | 931-19-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | G41PJ47D1I |
| NIST Chemistry Reference | Pyridine, 2-methyl-, 1-oxide(931-19-1) |
| EPA Substance Registry System | 2-Methylpyridine-1-oxide (931-19-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn,F | |||||||||
| Risk Statements | 36/37/38-20/21/22-10 | |||||||||
| Safety Statements | 26-36-24/25-16 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Picoline-N-oxide price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P42207 | 2-Methylpyridine N-oxide ≥96% | 931-19-1 | 100g | $140 | 2023-06-20 | Buy |
| TCI Chemical | P0418 | 2-Methylpyridine N-Oxide >99.0%(GC) | 931-19-1 | 25g | $34 | 2026-04-30 | Buy |
| TCI Chemical | P0418 | 2-Methylpyridine N-Oxide >99.0%(GC) | 931-19-1 | 500g | $247 | 2026-04-30 | Buy |
| Usbiological | 288237 | 2-Picoline N-oxide Asreported | 931-19-1 | 250g | $403 | 2026-06-03 | Buy |
| Usbiological | 288237 | 2-Picoline N-oxide Asreported | 931-19-1 | 500g | $616 | 2026-06-03 | Buy |
2-Picoline-N-oxide Chemical Properties, Uses, Production
Chemical Properties
light yellow to brown crystalline low melting mass
Uses
2-Picoline N-oxide is used in proteomics research. Also used as pharmaceutical intermediates.
Application
2-Methylpyridine 1-oxide is a useful building block for organic synthesis.
Definition
ChEBI: Picoline N-oxide is a member of methylpyridines and a member of pyridine N-oxides.
Synthesis
K2CO3 (20 mmol) and urea peroxide (10 mmol) were dissolved in dry 1,4-dioxane (100 mL), which was then stirred and reacted at room temperature for 1 hour. Trifluoroacetic anhydride (10 mmol) was added dropwise to the mixture below 12 C to bring the mixture back to room temperature. To the reaction mixture was added the corresponding 2-methylpyridine (1 mmol) and the mixture was stirred at 50 C overnight. The 1,4-dioxane was removed by distillation and replaced with dichloromethane, the mixture was washed with water (50 mL) and the resulting organic layer was dried over anhydrous MgSO4, filtered to remove the desiccant and the resulting filtrate was concentrated under vacuum to remove the solvent to give the 2-methylpyridine oxide.
Purification Methods
Purify the N-oxide by fractional distillation, and it can be recrystallised from *C6H6/hexane but is hygroscopic. [Bullitt & Maynard J Am Chem Soc 76 1370 1954, Ross et al. J Am Chem Soc 78 3625 1956, IR: Wiley & SlaymAker J Am Chem Soc 79 2233 1957.] The picrate has m 125-126.5o (from EtOH) [Boekelheide & Linn J Am Chem Soc 76 1286 1954]. The phthalate has m 115-116o (from EtOH) [den Hertog et al. Recl Trav Chim Pays-Bas 70 591 1951.]. [Beilstein 20 III/IV 2689, 20/5 V 479.]
2-Picoline-N-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 1846 | 58 |
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 2-Picoline-N-oxide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-30 | 2-Picoline-N-oxide
931-19-1
|
$100.00-2500.00 | 1KG | 98% | 5MT per month | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2019-07-06 | 2-Picoline-N-oxide
931-19-1
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-Picoline-N-oxide
931-19-1
- $100.00-2500.00
- 98%
- Anhui Dexinjia Biopharm Co., Ltd
-
- 2-Picoline-N-oxide
931-19-1
- $1.00
- 98%
- Career Henan Chemical Co
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