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2-Chloro-5-(phenylmethoxy)-pyrimidine

2-Chloro-5-(phenylmethoxy)-pyrimidine Structure
2-Chloro-5-(phenylmethoxy)-pyrimidine structure
CAS No.
138274-14-3
Chemical Name:
2-Chloro-5-(phenylmethoxy)-pyrimidine
Synonyms
5-(benzyloxy)-2-chloropyrimidine;2-Chloro-5-(benzyloxy)-pyrimidine;2-chloro-5-(phenylmethoxy)-pyrimidine;2-chloro-5-(benzenemethoxy)pyrimidine;Pyrimidine, 2-chloro-5-(phenylmethoxy)-;Benzenesulfonylchloride,9-(acetylamino)-;5-(benzyloxy)-2-chloropyrimidine138274-14-3;1,3-Dioxane-4,6-dione,2,2-dimethyl-7-phenyl-;2-Chloro-5-(phenylmethoxy)-pyrimidine ISO 9001：2015 REACH
CBNumber:
CB4854942
Molecular Formula:
C11H9ClN2O
Molecular Weight:
220.65
MDL Number:
MFCD09744017
MOL File:
138274-14-3.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:45
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2-Chloro-5-(phenylmethoxy)-pyrimidine Properties

Boiling point 387.0±17.0 °C(Predicted)
Density 1.278±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka -1.28±0.22(Predicted)
Appearance Off-white to light yellow Solid

2-Chloro-5-(phenylmethoxy)-pyrimidine price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR323169 5-(Benzyloxy)-2-chloropyrimidine >97% 138274-14-3 250mg $21 2026-06-04 Buy
Apolloscientific OR323169 5-(Benzyloxy)-2-chloropyrimidine >97% 138274-14-3 1g $24 2026-06-04 Buy
Apolloscientific OR323169 5-(Benzyloxy)-2-chloropyrimidine >97% 138274-14-3 5g $75 2026-06-04 Buy
Apolloscientific OR323169 5-(Benzyloxy)-2-chloropyrimidine >97% 138274-14-3 25g $349 2026-06-04 Buy
Apolloscientific OR323169 5-(Benzyloxy)-2-chloropyrimidine >97% 138274-14-3 100g $1389 2026-06-04 Buy
Product number Packaging Price Buy
OR323169 250mg $21 Buy
OR323169 1g $24 Buy
OR323169 5g $75 Buy
OR323169 25g $349 Buy
OR323169 100g $1389 Buy

2-Chloro-5-(phenylmethoxy)-pyrimidine Chemical Properties, Uses, Production

Synthesis

Benzyl bromide

100-39-0

2-Chloro-5-hydroxypyrimidine

4983-28-2

2-Chloro-5-(phenylmethoxy)-pyrimidine

138274-14-3

Example 9: Synthesis of 2-chloro-5-(phenylmethoxy)pyrimidine (compound 31) Under the guidance of the reference reaction scheme, potassium carbonate (11.6 g, 84.3 mmol) was added to a 500 mL methanol solution containing 10 g of 2-chloro-5-hydroxypyrimidine (76.6 mmol), followed by benzyl bromide (10.1 mL, 84.3 mmol). The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, water (300 mL) was added to terminate the reaction. Methanol was removed by evaporation and the remaining aqueous layer was extracted with chloroform. The combined chloroform layers were washed with brine, dried with anhydrous magnesium sulfate and filtered. After removal of the solvent, the product was purified by silica gel column chromatography using 100:1 chloroform:methanol as eluent to afford 15 g (89% yield) of 2-chloro-5-(phenylmethoxy)pyrimidine (31) as a white solid. 1H NMR (CDCl3) δ 8.27 (s, 2H), 7.37-7.30 (m, 5H), 5.09 (s, 2H).

References

[1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2288 - 2300
[2] Patent: US2014/235858, 2014, A1. Location in patent: Paragraph 0095
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 22, p. 8796 - 8805
[4] Patent: WO2011/147951, 2011, A1. Location in patent: Page/Page column 63

2-Chloro-5-(phenylmethoxy)-pyrimidine synthesis

100-39-0
4983-28-2
138274-14-3
Synthesis of 2-Chloro-5-(phenylmethoxy)-pyrimidine from Benzyl bromide and 2-Chloro-5-hydroxypyrimidine

2-Chloro-5-(phenylmethoxy)-pyrimidine Preparation Products And Raw materials

Raw materials

Benzyl bromide 2-Chloro-5-hydroxypyrimidine Potassium carbonate Methanol

Preparation Products

2-Chloro-5-(phenylmethoxy)-pyrimidine Suppliers

Global Suppliers ( 119)
Supplier Tel Email Country ProdList Advantage
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai ChriChem Co., Ltd. 021-54880687 China 510 55
Supplier Advantage
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
SynAsst Chemical. 55
Shanghai ChriChem Co., Ltd. 55

View Latest Price from 2-Chloro-5-(phenylmethoxy)-pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-(phenylmethoxy)-pyrimidine pictures 2025-06-25 2-Chloro-5-(phenylmethoxy)-pyrimidine
138274-14-3
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
2-Chloro-5-(phenylmethoxy)-pyrimidine pictures 2020-02-01 2-Chloro-5-(phenylmethoxy)-pyrimidine
138274-14-3
 $1.00 1KG 98% 200kgs Career Henan Chemical Co

2-Chloro-5-(phenylmethoxy)-pyrimidine Spectrum

2-Chloro-5-(phenylmethoxy)-pyrimidine(138274-14-3)1HNMR

138274-14-3 (2-Chloro-5-(phenylmethoxy)-pyrimidine) Related Search:

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2-chloro-5-(phenylmethoxy)-pyrimidine 5-(benzyloxy)-2-chloropyrimidine138274-14-3 Pyrimidine, 2-chloro-5-(phenylmethoxy)- 2-Chloro-5-(phenylmethoxy)-pyrimidine ISO 9001：2015 REACH 1,3-Dioxane-4,6-dione,2,2-dimethyl-7-phenyl- Benzenesulfonylchloride,9-(acetylamino)- 2-Chloro-5-(benzyloxy)-pyrimidine 2-chloro-5-(benzenemethoxy)pyrimidine 5-(benzyloxy)-2-chloropyrimidine 138274-14-3 Heterocycle-Pyrimidine series