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2-Chloro-5-chloromethylthiazole

2-Chloro-5-chloromethylthiazole Structure
2-Chloro-5-chloromethylthiazole structure
CAS No.
105827-91-6
Chemical Name:
2-Chloro-5-chloromethylthiazole
Synonyms
ccmt;2-CHLORO-5-CHLOROMETHYL-1,3-THIAZOLE;oro-5-(chL;2-Chloro-5-chl;2-Chloro-5-chloromet;2-Chloro-5-Chloromethyl;Clomethiazolum Impurity 4;2-CHLORO-5-CHLOROMETHYLTHIAZOLE;2-Chloro-5-chloromehtylthiazole;2-Chloro-5-(chlormethyl)thiazole
CBNumber:
CB0366188
Molecular Formula:
C4H3Cl2NS
Molecular Weight:
168.04
MDL Number:
MFCD01073549
MOL File:
105827-91-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-29 20:13:11
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2-Chloro-5-chloromethylthiazole Properties

Melting point 31
Boiling point 268.6±32.0 °C(Predicted)
Density 1.503±0.06 g/cm3(Predicted)
refractive index n20/D1.571
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility soluble in Methanol
pka 0.19±0.10(Predicted)
color White to Light yellow
BRN 5861439
InChI InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2
InChIKey VRMUIVKEHJSADG-UHFFFAOYSA-N
SMILES S1C(CCl)=CN=C1Cl
CAS DataBase Reference 105827-91-6(CAS DataBase Reference)
FDA UNII 857BYZ5HZD

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)Environment (GHS09)
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H302-H311-H314-H317-H411
Precautionary statements  P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P501
Hazard Codes  Xi,N,T
Risk Statements  36/37/38-51/53-43-34-24-22
Safety Statements  26-37-61-45-36/37/39
RIDADR  2922
WGK Germany  3
Hazard Note  Irritant
HazardClass  8
PackingGroup  Ⅱ
HS Code  29349990
REACH Registrations Active

2-Chloro-5-chloromethylthiazole price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C3295 2-Chloro-5-(chloromethyl)thiazole 105827-91-6 5G $17 2026-04-30 Buy
TCI Chemical C3295 2-Chloro-5-(chloromethyl)thiazole 105827-91-6 25G $45 2026-04-30 Buy
Usbiological 416851 2-Chloro-5-(chloromethyl)thiazole 105827-91-6 5g $312 2026-06-03 Buy
Usbiological 416851 2-Chloro-5-(chloromethyl)thiazole 105827-91-6 10g $396 2026-06-03 Buy
TRC TRC-C367145-5G 2-Chloro-5-(chloromethyl)thiazole 105827-91-6 5g $68 2026-06-03 Buy
Product number Packaging Price Buy
C3295 5G $17 Buy
C3295 25G $45 Buy
416851 5g $312 Buy
416851 10g $396 Buy
TRC-C367145-5G 5g $68 Buy

2-Chloro-5-chloromethylthiazole Chemical Properties,Uses,Production

Description

2-Chloro-5-chloromethylthiazole is used as pharmaceutical and agrochemical intermediate. It is also used as intermediate of insecticides Thiamethoxam and Clothianidin. It is also useful in in the synthesis of Ritonavir (R535000); a second-generation anti-AIDS drug and a selective HIV protease inhibitor.

Chemical Properties

White crystal or powder

Uses

2-Chloro-5-(chloromethyl)thiazole is a useful synthetic intermediate used in the synthesis of Ritonavir (R535000)

Synthesis

To a 2-liter round bottomed flask equipped with a mechanical stirrer, thermometer and a condenser, whose outlet was vented into an aqueous sodium hydroxide trap, was charged the crude mixture of cis- and trans-3-chloropropenyl isothiocyanates (504.2 g, 3.79 mol) and chloroform (600 mL). The mixture was stirred and heated to reflux. Chlorine (267.1 g, 3.77 mole) gas was bubbled under the surface of the reaction over a period of 6-8 h. The conversion of the isothiocyanates to 2-chloro-5- (chloromethyl)thiazole was monitored by GC. When the reaction was shown to be complete by GC analysis, the reaction mixture was cooled and then filtered. The filtrate was concentrated on the rotary evaporator to remove chloroform. Sodium bicarbonate (approximately 0.25 equivalents) was added to the concentrated filtrate, and the product 2-chloro-5-chloromethylthiazole was distilled at 97 °C under vacuum (6mm/Hg). The yield after distillation was 43%. 1 H NMR (CDCl3) δ: 7.3 (s, 1H); 4.6 (s, 2H). 13C NMR (CDCl3) δ: 152.6 (C-2); 140.2 (C-4); 137.5 (C-5); 37.1 (-CH2-).
2-Chloro-5-chloromethylthiazole

References

[1] Patent: CN108484524, 2018, A. Location in patent: Paragraph 0051; 0052; 0053; 0054
[2] Patent: CN105294595, 2016, A. Location in patent: Paragraph 0013; 0014; 0015; 0016; 0017
[3] Journal of Agricultural and Food Chemistry, 2004, vol. 52, # 7, p. 1918 - 1922
[4] Patent: CN107935960, 2018, A. Location in patent: Paragraph 0031-0043
[5] Patent: CN105949145, 2016, A. Location in patent: Paragraph 0045; 0046

2-Chloro-5-chloromethylthiazole Preparation Products And Raw materials

Raw materials

Chloroform 2-chloro-3-isothiocyanato-prop-1-ene Sulfuryl chloride 2-Chloro-5-methylthiazole Lenalidomide Impurity 13
5-Methylene-1,3-thiazolidine-2-thione 1-Propene, 3-chloro-1-isothiocyanato-, (1E)- Allyl isothiocyanate Chlorine Carbon tetrachloride

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Preparation Products

2-[(2-Chloro-thiazol-5-ylMethyl)-aMino]-ethanol Thiamethoxam

2-Chloro-5-chloromethylthiazole Suppliers

Global( 440)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Huasheng High-tech Industry Co., LTD 18660771812 2103518043@qq.com China 83 58
Yueyang Baolai New Materials Technology Co., Ltd. 190-73057600 13786054469 baolai@163.cn China 73 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Shandong Huasheng High-tech Industry Co., LTD 58
Yueyang Baolai New Materials Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62

View Lastest Price from 2-Chloro-5-chloromethylthiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-chloromethylthiazole pictures 2026-09-12 2-Chloro-5-chloromethylthiazole
105827-91-6
 0.99 RongNa Biotechnology Co.,Ltd
2-Chloro-5-chloromethylthiazole pictures 2026-09-07 2-Chloro-5-chloromethylthiazole
105827-91-6
 1kg 99%min 20tons HANGZHOU HAILAN CHEMICAL CO.,LTD.
2-Chloro-5-(chloromethyl)thiazole pictures 2026-09-02 2-Chloro-5-(chloromethyl)thiazole
105827-91-6
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd

2-Chloro-5-chloromethylthiazole Spectrum

2-Chloro-5-chloromethylthiazole(105827-91-6)1HNMR

105827-91-6(2-Chloro-5-chloromethylthiazole)Related Search:

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2-CHLORO-5-CHLOROMETHYLTHIAZOLE 2-CHLORO-5-(CHLOROMETHYL)-1,3-THIAZOLE[FOR THIAMETHOXAM] 2-CHLORO-5-CHLOROMETHYL THIAZOLE, 98+% 2-chloro-5-(chloromethyl)thiozole Thiazole, 2-chloro-5-(chloromethyl)- (9CI) 2-Chloro-5-(chlormethyl)thiazole 2-Chloro-5-chloromehtylthiazole 2-Chloro-5-Chloromethyl 2-Chloro-5-chloromet 2-Chloro-5-thiazolylmethyl chloride Thiazole,2-chloro-5-(chloroMethyl)- 2-Chloro-5-chl 2 Chloro 5 Chloro Methyl Thiazole(Ccmt) 2-Chloro-5-chloromethylthiazole 98% oro-5-(chL 2-CHLORO-5-(CHLOROMETHYL)-THIAZOLE HYDROCHLORIDE Clomethiazolum Impurity 4 2-CHLORO-5-CHLOROMETHYL-1,3-THIAZOLE ccmt 105827-91-6 65075-09-0 18296-02-3 C4H3NSCl2 C4H3C12NS C4H3Cl2NS Thiazoles Pesticide intermediate HALOMETYL Miscellaneous API bc0001 105827-91-6