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3-Hydroxy-4-methoxybenzonitrile

CAS No.
52805-46-6
Chemical Name:
3-Hydroxy-4-methoxybenzonitrile
Synonyms
Benzonitrile, 3-hydroxy-4-Methoxy-;ISOVANILLONITRILE;CBI-BB ZERO/005397;2-methoxy-5-cyanophenol;5-Cyano-2-methoxyphenol;3-Hydroxy-4-methoxybenzonitril;3-HYDROXY-4-METHOXYBENZONITRILE;3-Hydroxy-4-methoxy benzonitrile 95+%;3-Hydroxy-4-methoxybenzonitrile ISO 9001:2015 REACH;3-HYDROXY-4-METHOXYBENZONITRILE (ISOVANILLONITRILE)
CBNumber:
CB6287199
Molecular Formula:
C8H7NO2
Molecular Weight:
149.15
MDL Number:
MFCD02258854
MOL File:
52805-46-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:17:26

3-Hydroxy-4-methoxybenzonitrile Properties

Melting point 124 °C
Boiling point 300.8±27.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 8.59±0.10(Predicted)
Appearance White to off-white Solid
CAS DataBase Reference 52805-46-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
HS Code  29269090
REACH Registrations Inactive

3-Hydroxy-4-methoxybenzonitrile price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FH29690 3-Hydroxy-4-methoxybenzonitrile 52805-46-6 0.25kg $150 2026-06-04 Buy
Biosynth FH29690 3-Hydroxy-4-methoxybenzonitrile 52805-46-6 0.05kg $150 2026-06-04 Buy
Biosynth FH29690 3-Hydroxy-4-methoxybenzonitrile 52805-46-6 0.5kg $171.99 2026-06-04 Buy
Biosynth FH29690 3-Hydroxy-4-methoxybenzonitrile 52805-46-6 1kg $272.58 2026-06-04 Buy
Apolloscientific OR345595 3-Hydroxy-4-methoxy benzonitrile >98% 52805-46-6 25g $21 2026-06-04 Buy
Product number Packaging Price Buy
FH29690 0.25kg $150 Buy
FH29690 0.05kg $150 Buy
FH29690 0.5kg $171.99 Buy
FH29690 1kg $272.58 Buy
OR345595 25g $21 Buy

3-Hydroxy-4-methoxybenzonitrile Chemical Properties, Uses, Production

Synthesis

Isovanillin

621-59-0

3-Hydroxy-4-methoxybenzonitrile

52805-46-6

The general procedure for synthesizing 3-hydroxy-4-methoxybenzonitrile from isovanillin was as follows: 14.2 g of isovanillin was dissolved in 75 mL of formic acid, 15 g of sodium formate was added, and stirred at 85 °C. Subsequently, 9 g of hydroxylamine hydrochloride was added in batches, and the reaction mixture was kept at 85 °C and continued to be stirred for 4 hours. Upon completion of the reaction, the mixture was poured into a nearly saturated sodium chloride solution and a precipitate was precipitated. The precipitate was separated by filtration, washed sequentially with water and petroleum ether, and dried to give the product. The yield was 14.2 g. The yield was 93% of the theoretical value. The product was analyzed by HPLC-MS (Method D) with a retention time (Rt) of 1.18 min.

References

[1] Patent: WO2011/92128, 2011, A1. Location in patent: Page/Page column 37
[2] Patent: US2012/28939, 2012, A1. Location in patent: Page/Page column 18
[3] Patent: CN105330586, 2016, A. Location in patent: Paragraph 0055; 0056
[4] Patent: CN105461602, 2016, A. Location in patent: Paragraph 0049; 0050
[5] Molecules, 2017, vol. 22, # 10,

3-Hydroxy-4-methoxybenzonitrile Preparation Products And Raw materials

Global Suppliers ( 222)
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59

View Latest Price from 3-Hydroxy-4-methoxybenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Hydroxy-4-methoxybenzonitrile pictures 2019-07-14 3-Hydroxy-4-methoxybenzonitrile
52805-46-6
$8.80 1KG 97%-99% 100kg Career Henan Chemical Co
 3-Hydroxy-4-methoxybenzonitrile pictures 2019-07-06 3-Hydroxy-4-methoxybenzonitrile
52805-46-6
$8.00 1kg 98% 100KG Career Henan Chemical Co

3-Hydroxy-4-methoxybenzonitrile Spectrum

ISOVANILLONITRILE CBI-BB ZERO/005397 Benzonitrile, 3-hydroxy-4-Methoxy- 3-HYDROXY-4-METHOXYBENZONITRILE 3-HYDROXY-4-METHOXYBENZONITRILE (ISOVANILLONITRILE) 3-Hydroxy-4-methoxybenzonitril 5-Cyano-2-methoxyphenol Gefitinib IMpurity (3-Hydroxy-4-Methoxybenzonitrile) 3-Hydroxy-4-methoxy benzonitrile 95+% 3-Hydroxy-4-methoxybenzonitrile ISO 9001:2015 REACH 2-methoxy-5-cyanophenol 52805-46-6 Gefitinib Aromatic Nitriles bc0001