ChemicalBook >> CAS DataBase List >>2,6-Dihydroxyquinoline
2,6-Dihydroxyquinoline
- CAS No.
- 19315-93-6
- Chemical Name:
- 2,6-Dihydroxyquinoline
- Synonyms
- QUINOLIN-6-OL;quinoline-2,6-diol;AKOS 222-06;2,6-QUINOLINEDIOL;6-hydroquinilinone;Biotin Impurity 38;TIMTEC-BB SBB004117;2,6-DIHYDROXYQUINOLINE;2, 6-Hydroxy-quinoline;6-Hydroxyquinolin-2-one
- CBNumber:
- CB5155064
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD03840564
- MOL File:
- 19315-93-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 02:30:20
| Melting point | 188-190 °C(lit.) |
|---|---|
| Boiling point | 449.4±45.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.61±0.20(Predicted) |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C9H7NO2/c11-7-2-3-8-6(5-7)1-4-9(12)10-8/h1-5,11H,(H,10,12) |
| InChIKey | AQLYZDRHNHZHIS-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(O)C=C2)C=CC1=O |
| CAS DataBase Reference | 19315-93-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| target organs | Respiratory system |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | VC4130000 |
| F | 8 |
| HS Code | 29334900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2,6-Dihydroxyquinoline price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D2822 | 2,6-Dihydroxyquinoline >98.0%(HPLC)(T) | 19315-93-6 | 1g | $100 | 2026-04-30 | Buy |
| TCI Chemical | D2822 | 2,6-Dihydroxyquinoline >98.0%(HPLC)(T) | 19315-93-6 | 5g | $299 | 2026-04-30 | Buy |
| Usbiological | H9110-20C | 6-Hydroxyquinoline-(1H)-2-one (1,2-Dihydro-6-hydroxy-2-oxoquinoline, 6-Hydroxy-1H-quinolin-2-one) | 19315-93-6 | 250mg | $333 | 2026-06-03 | Buy |
| TRC | TRC-H953250-250MG | 6-Hydroxyquinoline-(1H)-2-one | 19315-93-6 | 250mg | $70 | 2026-06-03 | Buy |
| TRC | TRC-H953250-2.5G | 6-Hydroxyquinoline-(1H)-2-one | 19315-93-6 | 2.5g | $231 | 2026-06-03 | Buy |
2,6-Dihydroxyquinoline Chemical Properties, Uses, Production
Synthesis
Synthesis of compound (3):
In a 100mL three-necked flask equipped with a gas absorption device and a reflux condenser, trans-4-methoxyphenylacrylic acid (17.8g, 0.10mol) and toluene (55mL) were added, and thionyl chloride (11.9g, 0.10mol) was added dropwise. The mixture was slowly heated to 70℃ and reacted at this temperature for 4 hours. After cooling, the excess thionyl chloride was removed by vacuum concentration. The residue was frozen to precipitate a light yellow solid, which was recrystallized from dichloromethane to give 17.3g of white crystals, with a yield of 88.0%.
Synthesis of compound (4): 60 mL of tetrahydrofuran, 12.1 g of 4-aminophenylboronic acid (88.0 mmol), and 13.3 g of triethylamine (132.0 mmol) were added to a 250 mL three-necked flask. Compound (3) (17.3 g, 88.0 mmol) dissolved in tetrahydrofuran (70 mL) was added dropwise at -5 to 0 °C. After the addition was complete, the mixture was stirred at room temperature for 2 hours. The pH of the reaction solution was acidified to 2-3 with concentrated hydrochloric acid, and a large amount of white solid precipitated. The solid was filtered, washed with water until neutral, and dried to obtain 24.6 g of white solid product, with a yield of 94.1%. Synthesis of 6-hydroxy-2(1H)-quinolinone compound (1): Add the product from the previous step (24.6 g, 82.7 mmol) and 250 mL of toluene to a 500 mL three-necked flask, cool to 0 °C, add 32.2 g (4.2 mmol) of B(C6F5) and 15.4 g (115.8 mmol) of anhydrous aluminum trichloride in portions, slowly heat to 90 °C, continue stirring for 2 hours, pour the reaction solution into 800 mL of glacial hydrochloric acid solution to make the pH 2-3, stir for 1 hour, separate the layers, and retain the organic layer. Acetic acid (49.6 g, 0.827 mol) was added dropwise to the obtained organic layer, followed by the addition of 30% H₂O₂ (9.4 g, 82.7 mmol) solution at 0–10 °C. After the addition was complete, the mixture was kept at 0–10 °C for 1 hour, then stirred at room temperature for another hour. Sodium bisulfite solution was added dropwise to quench the peroxides. The organic layer was separated, washed once with saturated brine, and concentrated under reduced pressure. The crude solid was recrystallized from methanol to give 10.8 g of a white solid product, 6-hydroxy-2(1H)-quinolinone, with a yield of 80.7%, mp 300 °C, and a purity of 99.2%.Chemical Properties
Off-White Solid
Uses
6-Hydroxyquinoline-(1H)-2-one (cas# 19315-93-6) is a compound useful in organic synthesis.
Uses
Reactant involved in synthesis of:
- (Benzyloxy)methylquinolinone derivatives for use as PDE3 inhibitors
- Substances related to cilostazol
- 2,6-Quinolinyl derivatives for use as VLA-4 / VCAM-1 antagonists
Definition
ChEBI: Quinoline-2,6-diol is a dihydroxyquinoline that is quinoline in which the hydrogens at positions 2 and 6 are replaced by hydroxy groups.
General Description
2,6-Quinolinediol is a substituted quinoline compound. It has been prepared starting from 6-methoxyquinoline. It has been reported to be one of the UV-absorbing compounds (UAC) found in cow milk.
2,6-Dihydroxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 251)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai RC Chemicals Co., Ltd. | 21-58661250 18217085189; | 3059772675@qq.com | China | 131 | 64 |
| Shanghai Jingjinchem Co., Ltd. | 021-13817626287 13817626287 | 1094777898@qq.com | China | 110 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Latest Price from 2,6-Dihydroxyquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 6-HYDROXYQUINOLINE
19315-93-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-05-28 | 6-HYDROXYQUINOLINE
19315-93-6
|
$10.00-30.00 | 10kg | 99% | 100000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2021-10-14 | 6-HYDROXYQUINOLINE
19315-93-6
|
$10.00 | 1KG | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 6-HYDROXYQUINOLINE
19315-93-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-HYDROXYQUINOLINE
19315-93-6
- $10.00-30.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 6-HYDROXYQUINOLINE
19315-93-6
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
19315-93-6 (2,6-Dihydroxyquinoline) Related Search:
7-Hydroxyquinolinone
2-hydroxy-6-methyl-1H-quinolin-4-one
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
2,4-Quinolinediol
2,6-Dihydroxyquinoline
Cilostamide
2,4-Dihydroxy-6-methoxyquinoline
3-Quinolinecarboxaldehyde,6-ethoxy-1,2-dihydro-2-oxo-(9CI)
6-hydroxy-4-methyl-1H-quinolin-2-one
AKOS AU36-M576
1of4
TIMTEC-BB SBB004117
6-HYDROXY-2(1H)-QUINOLINONE
6-HYDROXY-2(H)-QUINOLINONE
AKOS 222-06
6-hydroquinilinone
1,2-Dihydro-6-hydroxy-2-oxoquinoline
6-Hydroxy-1H-quinolin-2-one
6-Hydroxyquinoline-(1H)-2-one
2,6-QUINOLINEDIOL
2,6-DIHYDROXYQUINOLINE
Brexpiprazole Impurity 19 ,6-hydroxyquinolin-2(1H)-one
2(1H)-Quinolinone, 6-hydroxy-
6-Hydroxy-1,2-dihydroquinoline-2-one
6-hydroxyquinolin-2(1H)-one
6-Hydroxyquinolin-2-one
2, 6-Hydroxy-quinoline
6-Hydroxy-2(1H)-quinolinone
2,6-Quinolinediol
2,6-Dihydroxyquinoline>
Aripiprazole Impurity 31 (2,6-quinolinediol)
6-HYDROXYQUINOLINE ISO 9001：2015 REACH
3, 4-Dihydro-6-hydroxycarbostyril/6-Hydroxy Dihydroquinolinone/3,4-Dihydro 6-hydroxycarbostyril
Biotin Impurity 38
QUINOLIN-6-OL
quinoline-2,6-diol
19315-93-6
9315-93-6
Heterocyclic Building Blocks
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