ChemicalBook >> CAS DataBase List >>3',4',5'-TRIFLUOROACETOPHENONE

3',4',5'-TRIFLUOROACETOPHENONE

3',4',5'-TRIFLUOROACETOPHENONE structure

CAS No.: 220141-73-1

Chemical Name:: 3',4',5'-TRIFLUOROACETOPHENONE

Synonyms: 3',4',5'-TRIFLUOROACETOPHE;3,4,5-TRIFLUOROACETOPHENONE;3',4',5'-Trifluoroacetophenone;1-(3,4,5-trifluorophenyl)ethanone;3',4',5'-Trifluoroacetophenone97%;3',4',5'-Trifluoroacetophenone 97%;Ethanone, 1-(3,4,5-trifluorophenyl)-;1-(3,4,5-Trifluorophenyl)ethan-1-one;3′,4′,5′-Trifluoroacetophenone, CAS 220141-73-1

CBNumber:: CB5193754

Molecular Formula:: C8H5F3O

Molecular Weight:: 174.12

MDL Number:: MFCD00083533

MOL File:: 220141-73-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

Product description	Number	Pack Size	Price
3',4',5'-Trifluoroacetophenone	T3825	5G	$63
3',4',5'-Trifluoroacetophenone	T3825	25G	$190
3',4',5'-TRIFLUOROACETOPHENONE 95.00%	HCH0020656	1G	$613.31
3',4',5'-Trifluoroacetophenone 98%	PC6755	100g	$218
3',4',5'-TRIFLUOROACETOPHENONE 95.00%	HCH0020656	5G	$892.82
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3',4',5'-TRIFLUOROACETOPHENONE Properties

Boiling point	209℃
Density	1.303
refractive index	1.473
Flash point	>100°C
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	Colorless to Light yellow
CAS DataBase Reference	220141-73-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi,F

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

1993

Hazard Note

Irritant/Flammable

HazardClass

IRRITANT

HS Code

2914790090

NFPA 704

	1
2		0

3',4',5'-TRIFLUOROACETOPHENONE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T3825	3',4',5'-Trifluoroacetophenone	220141-73-1	5G	$63	2025-07-31	Buy
TCI Chemical	T3825	3',4',5'-Trifluoroacetophenone	220141-73-1	25G	$190	2025-07-31	Buy
American Custom Chemicals Corporation	HCH0020656	3',4',5'-TRIFLUOROACETOPHENONE 95.00%	220141-73-1	1G	$613.31	2021-12-16	Buy
Apolloscientific	PC6755	3',4',5'-Trifluoroacetophenone 98%	220141-73-1	100g	$218	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0020656	3',4',5'-TRIFLUOROACETOPHENONE 95.00%	220141-73-1	5G	$892.82	2021-12-16	Buy

Product number	Packaging	Price	Buy
T3825	5G	$63	Buy
T3825	25G	$190	Buy
HCH0020656	1G	$613.31	Buy
PC6755	100g	$218	Buy
HCH0020656	5G	$892.82	Buy

3',4',5'-TRIFLUOROACETOPHENONE Chemical Properties,Uses,Production

Chemical Properties

colorless to clear liquid

Uses

3',4',5'-Trifluoroacetophenone is an organic intermediate that can be used to prepare the key mother nucleus (S)-N-[4-(1-aminoethyl)-2,6-difluorophenyl]methanesulfonamide of vanilloid compounds.

Synthesis

108-24-7

138526-69-9

220141-73-1

The general procedure for the synthesis of 3,4,5-trifluoroacetophenone from ethanoic anhydride and 3,4,5-trifluorobromobenzene was carried out as follows: firstly, iodine (361 mg, 1.42 mmol) was added to a solution of magnesium (3.53 g, 145 mmol) in tetrahydrofuran (100 ml) at room temperature, followed by slow dropwise addition of 3,4,5-trifluorobromobenzene (30.0 g, 142 mmol). The reaction mixture was stirred at the same temperature for 30 minutes. Next, a toluene solution (100 ml) containing copper (I) chloride (704 mg, 7.11 mmol) and acetic anhydride (16.0 g, 156 mmol) was added to the reaction mixture at 0°C. The reaction mixture was continued to be stirred at 0°C for 1 hour. After completion of the reaction, the mixture was poured into 2N aqueous hydrochloric acid solution and extracted with toluene. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The concentrated product was purified by silica gel column chromatography using ethyl acetate/hexane (1/10) as elution solvent to give 3,4,5-trifluoroacetophenone as a final yellow oil (yield 21.0 g, 85% yield).

References

[1] Patent: JP2016/84346, 2016, A. Location in patent: Paragraph 0056
[2] Patent: JP2016/84328, 2016, A. Location in patent: Paragraph 0191

3',4',5'-TRIFLUOROACETOPHENONE synthesis

Synthesis of 3',4',5'-TRIFLUOROACETOPHENONE from 5-Bromo-1,2,3-trifluorobenzene

3',4',5'-TRIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

5-Bromo-1,2,3-trifluorobenzene Acetic anhydride Copper(I) chloride Tetrahydrofuran Toluene

Magnesium iodine

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Preparation Products

3',4',5'-TRIFLUOROACETOPHENONE Suppliers

Global( 167)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	923	55
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58

Supplier	Advantage
Speranza Chemical Co., Ltd.	55
Capot Chemical Co.,Ltd.	60
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58

View Lastest Price from 3',4',5'-TRIFLUOROACETOPHENONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-14	3',4',5'-Trifluoroacetophenone 220141-73-1	US $0.00-0.00 / KG	1KG	98%	100MT/Year	Speranza Chemical Co., Ltd.
2021-07-13	3",4",5"-TRIFLUOROACETOPHENONE 220141-73-1	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	3",4",5"-TRIFLUOROACETOPHENONE 220141-73-1	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

3',4',5'-Trifluoroacetophenone
220141-73-1
US $0.00-0.00 / KG
98%
Speranza Chemical Co., Ltd.

3",4",5"-TRIFLUOROACETOPHENONE
220141-73-1
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3",4",5"-TRIFLUOROACETOPHENONE
220141-73-1
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3',4',5'-TRIFLUOROACETOPHENONE Spectrum

3',4',5'-TRIFLUOROACETOPHENONE(220141-73-1)¹HNMR

220141-73-1(3',4',5'-TRIFLUOROACETOPHENONE)Related Search:

Ethyl (pentafluorobenzoyl)acetate 3',4',5'-TRIFLUOROACETOPHENONE Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate PENTAFLUOROPHENACYL BROMIDE

2',3',4',5'-TETRAFLUOROACETOPHENONE DECAFLUOROBENZOPHENONE 2,3,4,5,6-PENTAFLUOROBENZOPHENONE 2',3',4',5',6'-PENTAFLUOROACETOPHENONE 3,4,5-TRIFLUOROBENZOPHENONE

4-Carboxy-alpha,alpha,alpha-trifluoroacetophenone 4-FLUORO-A,A,A-TRIFLUOROACETOPHENONE,4-FLUORO-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE 4'-(DIMETHYLAMINO)-2,2,2-TRIFLUOROACETOPHENONE,4'-N,N-DIMETHYLAMINO-2,2,2-TRIFLUOROACETOPHENONE Trifluoroacetophenone 4'-Ethoxyl-2,2,2-trifluoroacetophenone

2,2,2-TRIFLUORO-3'-(TRIFLUOROMETHYL)ACETOPHENONE 2'',3'',4''-TRIFLUOROACETOPHENONE 2',4',5'-Trifluoroacetophenone

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3,4,5-TRIFLUOROACETOPHENONE 3',4',5'-Trifluoroacetophenone 97% 3',4',5'-Trifluoroacetophenone97% 1-(3,4,5-trifluorophenyl)ethanone 1-(3,4,5-Trifluorophenyl)ethan-1-one Ethanone, 1-(3,4,5-trifluorophenyl)- 3',4',5'-Trifluoroacetophenone 3',4',5'-TRIFLUOROACETOPHE 3′,4′,5′-Trifluoroacetophenone, CAS 220141-73-1 220141-73-1 Fluorine series ketone