3',4',5'-Trifluoroacetophenone
- CAS No.
- 220141-73-1
- Chemical Name:
- 3',4',5'-Trifluoroacetophenone
- Synonyms
- 3',4',5'-TRIFLUOROACETOPHE;3,4,5-TRIFLUOROACETOPHENONE;3',4',5'-Trifluoroacetophenone;1-(3,4,5-trifluorophenyl)ethanone;3',4',5'-Trifluoroacetophenone97%;3',4',5'-Trifluoroacetophenone 97%;Ethanone, 1-(3,4,5-trifluorophenyl)-;1-(3,4,5-Trifluorophenyl)ethan-1-one;3′,4′,5′-Trifluoroacetophenone, CAS 220141-73-1
- CBNumber:
- CB5193754
- Molecular Formula:
- C8H5F3O
- Molecular Weight:
- 174.12
- MDL Number:
- MFCD00083533
- MOL File:
- 220141-73-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 209℃ |
|---|---|
| Density | 1.303 |
| refractive index | 1.473 |
| Flash point | >100°C |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Colorless to Light yellow |
| CAS DataBase Reference | 220141-73-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 1993 | |||||||||
| Hazard Note | Irritant/Flammable | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2914790090 | |||||||||
| NFPA 704 |
|
3',4',5'-Trifluoroacetophenone price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3825 | 3',4',5'-Trifluoroacetophenone | 220141-73-1 | 5G | $67 | 2026-04-30 | Buy |
| TCI Chemical | T3825 | 3',4',5'-Trifluoroacetophenone | 220141-73-1 | 25G | $202 | 2026-04-30 | Buy |
| Activate Scientific | AS33203 | 3`,4`,5`-Trifluoroacetophenone 98% | 220141-73-1 | 1g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS33203 | 3`,4`,5`-Trifluoroacetophenone 98% | 220141-73-1 | 5g | $36 | 2026-06-04 | Buy |
| Activate Scientific | AS33203 | 3`,4`,5`-Trifluoroacetophenone 98% | 220141-73-1 | 25g | $94 | 2026-06-04 | Buy |
3',4',5'-Trifluoroacetophenone Chemical Properties, Uses, Production
Chemical Properties
colorless to clear liquid
Uses
3',4',5'-Trifluoroacetophenone is an organic intermediate that can be used to prepare the key mother nucleus (S)-N-[4-(1-aminoethyl)-2,6-difluorophenyl]methanesulfonamide of vanilloid compounds.
Synthesis
108-24-7
138526-69-9
220141-73-1
The general procedure for the synthesis of 3,4,5-trifluoroacetophenone from ethanoic anhydride and 3,4,5-trifluorobromobenzene was carried out as follows: firstly, iodine (361 mg, 1.42 mmol) was added to a solution of magnesium (3.53 g, 145 mmol) in tetrahydrofuran (100 ml) at room temperature, followed by slow dropwise addition of 3,4,5-trifluorobromobenzene (30.0 g, 142 mmol). The reaction mixture was stirred at the same temperature for 30 minutes. Next, a toluene solution (100 ml) containing copper (I) chloride (704 mg, 7.11 mmol) and acetic anhydride (16.0 g, 156 mmol) was added to the reaction mixture at 0°C. The reaction mixture was continued to be stirred at 0°C for 1 hour. After completion of the reaction, the mixture was poured into 2N aqueous hydrochloric acid solution and extracted with toluene. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The concentrated product was purified by silica gel column chromatography using ethyl acetate/hexane (1/10) as elution solvent to give 3,4,5-trifluoroacetophenone as a final yellow oil (yield 21.0 g, 85% yield).
References
[1] Patent: JP2016/84346, 2016, A. Location in patent: Paragraph 0056
[2] Patent: JP2016/84328, 2016, A. Location in patent: Paragraph 0191
3',4',5'-Trifluoroacetophenone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 3',4',5'-Trifluoroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-14 | 3',4',5'-Trifluoroacetophenone
220141-73-1
|
1KG | 98% | 100MT/Year | Speranza Chemical Co., Ltd. | ||
 |
2021-07-13 | 3",4",5"-TRIFLUOROACETOPHENONE
220141-73-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 3",4",5"-TRIFLUOROACETOPHENONE
220141-73-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3',4',5'-Trifluoroacetophenone
220141-73-1
- 98%
- Speranza Chemical Co., Ltd.
-
- 3",4",5"-TRIFLUOROACETOPHENONE
220141-73-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3",4",5"-TRIFLUOROACETOPHENONE
220141-73-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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