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2-Amino-5-bromopyrazine

2-Amino-5-bromopyrazine structure

CAS No.: 59489-71-3

Chemical Name:: 2-Amino-5-bromopyrazine

Synonyms: 5-BROMOPYRAZIN-2-AMINE;BUTTPARK 29\02-91;5-BROMOPYRAZINAMINE;2-Amino-5-bromopyraz;5-Bromo-2-pyrazinamie;2-aimo-5-bromopyrazine;5-BROMO-2-PYRAZINAMINE;2-Bromo-5-aminopyrazine;5-Bromo-2-aminopyrazine;2-AMINO-5-BROMOPYRAZINE

CBNumber:: CB0446196

Molecular Formula:: C4H4BrN3

Molecular Weight:: 174

MDL Number:: MFCD00235015

MOL File:: 59489-71-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:43:28

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2-Amino-5-bromopyrazine Properties

Melting point	113-117 °C (lit.)
Boiling point	274.2±35.0 °C(Predicted)
Density	1.844±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Ethanol, Ethyl Acetate, Methanol
form	Brown Needles
pka	1.66±0.10(Predicted)
color	Light yellow to Brown
InChI	InChI=1S/C4H4BrN3/c5-3-1-8-4(6)2-7-3/h1-2H,(H2,6,8)
InChIKey	KRRTXVSBTPCDOS-UHFFFAOYSA-N
SMILES	C1(N)=NC=C(Br)N=C1
CAS DataBase Reference	59489-71-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

22-36/38-43-44-36/37/38-20/21/22

Safety Statements

26-37/39-45-36/37/39-22-36/

WGK Germany

Hazard Note

Irritant

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2

NFPA 704

	0
2		0

2-Amino-5-bromopyrazine price More Price(93)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	636320	2-Amino-5-bromopyrazine 97%	59489-71-3	1g	$103	2026-04-30	Buy
TCI Chemical	A1683	2-Amino-5-bromopyrazine >98.0%(GC)(T)	59489-71-3	1g	$39	2026-04-30	Buy
TCI Chemical	A1683	2-Amino-5-bromopyrazine >98.0%(GC)(T)	59489-71-3	5g	$134	2026-04-30	Buy
Usbiological	A1375-84	2-Amino-5-bromopyrazine		250mg	$319	2026-06-03	Buy
TRC	TRC-A601845-250MG	2-Amino-5-bromopyrazine	59489-71-3	250mg	$72	2026-06-03	Buy

Product number	Packaging	Price	Buy
636320	1g	$103	Buy
A1683	1g	$39	Buy
A1683	5g	$134	Buy
A1375-84	250mg	$319	Buy
TRC-A601845-250MG	250mg	$72	Buy

2-Amino-5-bromopyrazine Chemical Properties, Uses, Production

Chemical Properties

Brown Needles

Uses

Used without prior protection of the amino group in a palladium-catalyzed cross-coupling with pyridylboronic acids leading to pyrazinylpyridines.

Synthesis

5049-61-6

59489-71-3

Example 1A Synthesis of 5-bromo-2-pyrazinamine: 2-Aminopyrazine (15.0 g, 157 mmol) was dissolved in dichloromethane (900 mL), N-bromosuccinimide (28.2 g, 159 mmol) was added, and the reaction was stirred for 3.5 hours at room temperature. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth (Celite). The filtrate was treated with silica gel (300 g) and subsequently concentrated under reduced pressure. The resulting crude product was purified by fast column chromatography with 30% ethyl acetate/hexane as eluent to give 22.09 g (81.5% yield) of the target compound 5-bromo-2-pyrazinamine. Mass spectrum (APCI(+)) m/z: 174 ([M + H]+); 1H NMR (300 MHz, CDCl3) δ: 8.09 (d, J = 1.4 Hz, 1H), 7.77 (d, J = 1.7 Hz, 1H), 4.30-4.78 (br s, 2H).

References

[1] Heterocycles, 2012, vol. 86, # 2, p. 1323 - 1339
[2] Patent: US2004/259885, 2004, A1. Location in patent: Page 9; 10
[3] Patent: US2004/34038, 2004, A1. Location in patent: Page/Page column 10
[4] Patent: WO2011/7314, 2011, A1. Location in patent: Page/Page column 27
[5] Patent: WO2009/44162, 2009, A1. Location in patent: Page/Page column 169

2-Amino-5-bromopyrazine synthesis

Synthesis of 2-Amino-5-bromopyrazine from Aminopyrazine

2-Amino-5-bromopyrazine Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide Aminopyrazine Dichloromethane Magnesium sulfate Sodium carbonate

2-Amino-3,5-dibromopyrazine 2-Amino-3-bromopyrazine 3-Amino-6-bromopyrazine-2-carboxylic acid

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Preparation Products

2,5-Dibromopyrazine 2-Bromo-5-methoxypyrazine Cyclobutanecarbonitrile, 1-[6-(5-amino-2-pyrazinyl)-3-pyridinyl]- 5-(3-Thienyl)-2-pyrazinamine 6-Aminopyrazine-2-boronic acid pinacol ester

PyrazinaMine, 5-(4-chlorophenyl) 5-(4-methoxyphenyl)pyrazin-2-amine

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2-Amino-5-bromopyrazine Suppliers

Global Suppliers ( 462)

Supplier	Tel	Email	Country	ProdList	Advantage
Tongchuang Pharma(Suzhou). Co., Ltd.	0512-63263366 18912765016	tongtf110@sina.com	China	984	62
Nanjing Jubai Biomedical Technology Co., Ltd.	13585203734	info@jbzml.com	China	200	58
Nanjing Yingkun Chemical Co.,Ltd.	025-83212803 13382023051;13382003766	sales@yingkunchem.cn	China	44	58
Shanghai He Huan Chemical Co., Ltd.	021-60345187 13917602471	lzz841106@aliyun.com	China	483	58
Lanzhou Kangyuxin Biotechnology Co., Ltd.	0943-8293106	sales@kyxpharma.com	China	3552	58
Shanghai Pulikang Chemical Technology Co., Ltd	13105330140 13105330140	icyan@126.com	China	266	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65

Supplier	Advantage
Tongchuang Pharma(Suzhou). Co., Ltd.	62
Nanjing Jubai Biomedical Technology Co., Ltd.	58
Nanjing Yingkun Chemical Co.,Ltd.	58
Shanghai He Huan Chemical Co., Ltd.	58
Lanzhou Kangyuxin Biotechnology Co., Ltd.	58
Shanghai Pulikang Chemical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
future industrial shanghai co., ltd	65

View Latest Price from 2-Amino-5-bromopyrazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-Amino-5-bromopyrazine 59489-71-3	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-08-20	2-Amino-5-bromopyrazine 59489-71-3	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
2025-04-04	2-Amino-5-bromopyrazine 59489-71-3		1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-Amino-5-bromopyrazine
59489-71-3
$5.00
98%
Henan Fengda Chemical Co., Ltd

2-Amino-5-bromopyrazine
59489-71-3
$1.10
99.00%
Dideu Industries Group Limited

2-Amino-5-bromopyrazine
59489-71-3
98%
Henan Aochuang Chemical Co.,Ltd.

2-Amino-5-bromopyrazine Spectrum

2-Amino-5-bromopyrazine(59489-71-3)¹HNMR

59489-71-3 (2-Amino-5-bromopyrazine) Related Search:

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Aminoethoxyvinyl glycine hydrochloride Bromine Methyl 3-amino-6-bromopyrazine-2-carboxylate 3-Amino-6-bromopyrazine-2-carbonitrile 2-Amino-5-bromo-3-pyrrolidin-1-ylpyrazine

5-Bromo-pyrazine-2,3-diamine 2-Amino-3,5-dibromopyrazine 2-Amino-5-bromo-3-morpholin-4-ylpyrazine

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5-BROMOPYRAZINAMINE 5-BROMO-PYRAZIN-2-YLAMINE 5-BROMO-2-PYRAZINAMINE BUTTPARK 29\02-91 2-aimo-5-bromopyrazine 5-Bromo-2-aminopyrazine 2-AMINO-5-BROMOPYRAZINE: TECH. 2-Bromo-5-aminopyrazine 5-Bromo-2-pyrazinamie 2-amino-5-bromo-1,4-pyrazine 4-Imidazo[1,2-a]pyridin-5-yl-phenol 2-Amino-5-bromopyraz 5-Bromo-2-pyrazinamine, Tech. 2-AMINO-5-BROMOPYRAZINE 5-AMino-2-broMopyrazine 5-Bromopyrazin-2-amine, 2-Amino-5-bromo-1,4-diazine 2-Amino-5-bromopyrazine 5-Bromo-2-pyrazinamine 2- aMino-5- broMinepyrazine 2-Amino-5-bromopyrazine > 2-Pyrazinamine, 5-bromo- 2-Amino-5-bromopyrazine ISO 9001：2015 REACH 5-BROMOPYRAZIN-2-AMINE 59489-71-3 59487-71-3 58489-71-3 C4H4N3Br Heterocyclic Building Blocks Halogenated Heterocycles Chloropyrazines, etc. Pyrazines Building Blocks amine| alkyl bromide Chloropyrazines, etc. Bases & Related Reagents Nucleotides Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrazinesHeterocyclic Building Blocks Halides Pyrazines, Pyrimidines & Pyridazines Pyrazine Nucleotides and Nucleosides Pyrazines pharmacetical Amines and Anilines Heterocycles Amines Aromatics Building Blocks/Intermediates