D-1-N-Boc-prolinamide
- CAS No.
- 70138-72-6
- Chemical Name:
- D-1-N-Boc-prolinamide
- Synonyms
- 2-carbamoyL;D-N-BOC-PROLINAMIDE;1-BOC-D-PROLINAMIDE;N-ALPHA-BOC-D-PROLINEAMIDE;(Tert-Butoxy)Carbonyl D-Pro-NH2;(R)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylicacid, 2-(aminocarbonyl)-, 1,1-dimethy...;(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-
- CBNumber:
- CB5284601
- Molecular Formula:
- C10H18N2O3
- Molecular Weight:
- 214.26
- MDL Number:
- MFCD03419274
- MOL File:
- 70138-72-6.mol
| Melting point | 100-102 °C |
|---|---|
| Boiling point | 370.1±31.0 °C(Predicted) |
| Density | 1.155±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 15.97±0.20(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 70138-72-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
D-1-N-Boc-prolinamide price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | B56854 | D-1-N-BOC-PROLINAMIDE 98% | 70138-72-6 | 5G | $22 | 2026-04-30 | Buy |
| AstaTech | B56854 | D-1-N-BOC-PROLINAMIDE 98% | 70138-72-6 | 25G | $84 | 2026-04-30 | Buy |
| AstaTech | B56854 | D-1-N-BOC-PROLINAMIDE 98% | 70138-72-6 | 100G | $241 | 2026-04-30 | Buy |
| Matrix Scientific | 075206 | (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate | 70138-72-6 | 10.00g | $38 | 2026-05-18 | Buy |
| Matrix Scientific | 075206 | (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate | 70138-72-6 | 25.00g | $76 | 2026-05-18 | Buy |
D-1-N-Boc-prolinamide Chemical Properties,Uses,Production
Synthesis
37784-17-1
70138-72-6
General procedure for the synthesis of tert-butyl (R)-2-carbamoylpyrrolidine-1-carboxylate from Boc-D-proline: Example 1; Synthesis of tert-butyl (R)-2-carbamoylpyrrolidine-1-carboxylate. N-Methylmorpholine (9.85 g, 97.5 mmol) and isobutyl chloroformate (13.3 g, 97.5 mmol) were added to a THF solution (98 mL) of (R)-pyrrolidine-1,2-dicarboxylic acid 1- tert-butyl ester (20.0 g, 92.9 mmol) at -78 °C and stirred for 1 hour. Ammonium hydroxide (58 mL) was slowly added while the reaction system was warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction mixture was partitioned between dichloromethane and water. The organic phase was washed with 1 M HCl, dried over anhydrous sodium sulfate, filtered and concentrated to give the title product (10.8 g, 54%) as a colorless semi-solid.1H NMR (300 MHz, CDCl3): δ (ppm) 5.91-6.13 (m, 1H), 4.17-4.30 (m, 2H), 3.37-3.48 (m, 2H), 2.10- 2.18 (m, 2H), 1.84-1.96 (m, 2H), 1.45 (s, 9H).
References
[1] Patent: US2007/259926, 2007, A1. Location in patent: Page/Page column 9
[2] Tetrahedron, 2009, vol. 65, # 46, p. 9536 - 9541
D-1-N-Boc-prolinamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9849 | 55 |
View Lastest Price from D-1-N-Boc-prolinamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | D-1-N-BOC-PROLINAMIDE
70138-72-6
|
$100.00 | 1KG | 99% | Career Henan Chemical Co |
-
- D-1-N-BOC-PROLINAMIDE
70138-72-6
- $100.00
- 99%
- Career Henan Chemical Co
