tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate
- CAS No.
- 54503-10-5
- Chemical Name:
- tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate
- Synonyms
- Boc-DL-prolinaMide;N-Boc-D-Prolinamide;L-1-BOC-PROLINAMIDE;N-Boc-DL-prolinamide;1-Boc-piperidine-2-carboxamide;1-Boc-2-(AMinocarbonyl)pyrrolidine;1-(tert-Butoxycarbonyl)piperidine-2-carboxamide;tert-butyl 2-carbaMoylpyrrolidine-1-carboxylate;tert-Butyl 2-carbamoyllpyrrolidine-1-carboxylate;ert-butyl2-(aminocarbonyl)pyrrolidine-1-carboxylate
- CBNumber:
- CB4935285
- Molecular Formula:
- C10H18N2O3
- Molecular Weight:
- 214.26
- MDL Number:
- MFCD02183582
- MOL File:
- 54503-10-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P305+P351+P338 |
tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 132579 | tert-Butyl 2-carbamoyllpyrrolidine-1-carboxylate | 54503-10-5 | 5.00g | $504 | 2026-05-18 | Buy |
| Matrix Scientific | 132579 | tert-Butyl 2-carbamoyllpyrrolidine-1-carboxylate | 54503-10-5 | 25.00g | $1530 | 2026-05-18 | Buy |
| Matrix Scientific | 114832 | 1-(tert-Butoxycarbonyl)piperidine-2-carboxamide | 54503-10-5 | 1.00g | $165 | 2026-05-18 | Buy |
| Synthonix | B53253 | tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 54503-10-5 | 250mg | $17 | 2026-05-06 | Buy |
| Synthonix | B53253 | tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 54503-10-5 | 1g | $21 | 2026-05-06 | Buy |
tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate Chemical Properties,Uses,Production
Synthesis
15761-39-4
54503-10-5
GENERAL METHOD: 20 g (93 mmol) of Boc-L-proline was dissolved in 150 mL of anhydrous acetonitrile, and 19.5 g (120 mmol) of 1,1'-carbonyldiimidazole, 21.0 mL (150 mmol) of trimethylamine, and 19.2 g (200 mmol) of ammonium carbonate were added sequentially. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the mixture was poured into 250 mL of saturated potassium carbonate solution and extracted with dichloromethane (3 x 250 mL). The organic phases were combined, washed twice with 150 mL of water and dried over sodium sulfate. After removing the solvent under reduced pressure, the crude product was purified by rapid chromatography on silica gel with the eluent being ethylhexane-ethyl acetate (100:0→1:1). The product was obtained as 12.3 g in 62% yield. MS data: m/z (Irel, %) 215.1 (100) [M + H]+.
References
[1] Russian Journal of General Chemistry, 2017, vol. 87, # 4, p. 717 - 730
[2] Zh. Obshch. Khim., 2017, vol. 87, # 4, p. 584 - 596,13
[3] Synthetic Communications, 2007, vol. 37, # 21, p. 3793 - 3799
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 9, p. 2225 - 2239
[5] Tetrahedron, 2008, vol. 64, # 12, p. 2801 - 2815
tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2283 | 55 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
