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(4-Hydroxy-2-methyl)phenylboronic acid

(4-Hydroxy-2-methyl)phenylboronic acid Structure
(4-Hydroxy-2-methyl)phenylboronic acid structure
CAS No.
493035-82-8
Chemical Name:
(4-Hydroxy-2-methyl)phenylboronic acid
Synonyms
Tavaborole Impurity 3;4-Borono-3-methylphenol;Adipic Acid Impurity 11;5-hydroxytoluene-2-boronic acid;4-Hydroxy-2-methylphenylboronicaci;4-Hydroxy-2-methylphenylboronic aicd;2-Hydroxy-2-methylphenylboronic acid;(4-HYDROXY-2-METHYL)PHENYLBORONIC ACID;(4-HYDROXY-2-METHYL)BENZENEBORONIC ACID;B-(4-Hydroxy-2-methylphenyl)boronic acid
CBNumber:
CB5317615
Molecular Formula:
C7H9BO3
Molecular Weight:
151.96
MDL Number:
MFCD03788424
MOL File:
493035-82-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:26:26
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(4-Hydroxy-2-methyl)phenylboronic acid Properties

Melting point 100-104°C
Boiling point 361.4±52.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka 9.17±0.58(Predicted)
color White to Almost white
InChI 1S/C7H9BO3/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,9-11H,1H3
InChIKey OYIYNIONWDBJIF-UHFFFAOYSA-N
SMILES Cc1cc(O)ccc1B(O)O
CAS DataBase Reference 493035-82-8(CAS DataBase Reference)
UNSPSC Code 12352106
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38-41
Safety Statements  26-36/37/39-39
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  2931900090
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

(4-Hydroxy-2-methyl)phenylboronic acid price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical H1495 4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride) 493035-82-8 1g $141 2026-04-30 Buy
TCI Chemical H1495 4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride) 493035-82-8 5g $477 2026-04-30 Buy
Usbiological 280067 5-Hydroxytoluene-2-boronic acid Asreported 493035-82-8 500mg $333 2026-06-03 Buy
Usbiological 280067 5-Hydroxytoluene-2-boronic acid Asreported 493035-82-8 1g $559 2026-06-03 Buy
Usbiological 280067 5-Hydroxytoluene-2-boronic acid Asreported 493035-82-8 2g $851 2026-06-03 Buy
Product number Packaging Price Buy
H1495 1g $141 Buy
H1495 5g $477 Buy
280067 500mg $333 Buy
280067 1g $559 Buy
280067 2g $851 Buy

(4-Hydroxy-2-methyl)phenylboronic acid Chemical Properties,Uses,Production

Uses

suzuki reaction

Uses

(4-Hydroxy-2-methylphenyl)boronic Acid is a reactant in the preparation of biarylmethoxy nicotinamides as specific inhibitors of mycobacterium tuberculosis

Synthesis

3-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol

946427-03-8

(4-Hydroxy-2-methyl)phenylboronic acid

493035-82-8

The general procedure for the synthesis of 4-hydroxy-2-methylphenylboronic acid from 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is as follows: 1. sodium periodate (2.39 g, 11.15 mmol) was added to acetone and water (2:1, 36 mL) containing 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (870.4 mg, 3.72 mmol) and ammonium acetate (859.8 mg, 11.15 mmol) in a room temperature in a mixed solution. 2. The reaction mixture was stirred for 68 hours, then filtered and concentrated. 3. 3. Sodium chloride was added to the concentrated filtrate and extracted with ethyl acetate. 4. 4. The organic layer was dried with anhydrous magnesium sulfate, followed by filtration and concentration. 5. 5. The residue was purified by silica gel chromatography using 1:4 ethyl acetate:hexane as eluent to afford 275.7 mg (49% yield) of 4-hydroxy-2-methylphenylboronic acid as a solid. Product characterization data: 1H NMR (400 MHz, d6-DMSO): δ 9.28 (s, 1H), 7.70 (d, J = 9 Hz, 1H), 6.56-6.52 (m, 2H), 2.55 (s, 3H). ESI-LCMS m/z 151 (M-H)-.

References

[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 82

(4-Hydroxy-2-methyl)phenylboronic acid synthesis

946427-03-8
493035-82-8
Synthesis of (4-Hydroxy-2-methyl)phenylboronic acid from 3-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol

(4-Hydroxy-2-methyl)phenylboronic acid Preparation Products And Raw materials

Raw materials

3-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol Ammonium acetate Acetone Water Sodium periodate

Preparation Products

(4-Hydroxy-2-methyl)phenylboronic acid Suppliers

Global( 189)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Shanghai Longsheng chemical Co.,Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Chemsky（shanghai）International Co.,Ltd. 50

View Lastest Price from (4-Hydroxy-2-methyl)phenylboronic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(4-Hydroxy-2-methyl)phenylboronic acid pictures 2026-09-02 (4-Hydroxy-2-methyl)phenylboronic acid
493035-82-8
 $1.20-34.00 1kg 99% Henan Fengda Chemical Co., Ltd
(4-Hydroxy-2-methyl)phenylboronic acid pictures 2025-04-04 (4-Hydroxy-2-methyl)phenylboronic acid
493035-82-8
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(4-Hydroxy-2-methyl)phenylboronic acid pictures 2021-07-13 (4-Hydroxy-2-methyl)phenylboronic acid
493035-82-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

(4-Hydroxy-2-methyl)phenylboronic acid Spectrum

(4-Hydroxy-2-methyl)phenylboronic acid(493035-82-8)1HNMR

493035-82-8((4-Hydroxy-2-methyl)phenylboronic acid)Related Search:

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(4-HYDROXY-2-METHYL)BENZENEBORONIC ACID (4-HYDROXY-2-METHYL)PHENYLBORONIC ACID 4-Borono-3-methylphenol 5-hydroxytoluene-2-boronic acid Boronic acid, (4-hydroxy-2-methylphenyl)- (9CI) 4-Borono-3-methylphenol, 2-Borono-5-hydroxytoluene BORONIC ACID,B-(4-HYDROXY-2-METHYLPHENYL)- 4-Hydroxy-2-methylphenylboronic aicd 4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride) Tavaborole Impurity 3 4-Hydroxy-2-methylphenylboronicaci B-(4-Hydroxy-2-methylphenyl)boronic acid 4-Hydroxy-2-methylbenzeneboronic Acid (contains varying amounts of Anhydride) Adipic Acid Impurity 11 2-Hydroxy-2-methylphenylboronic acid 493035-82-8 ALCOHOL blocks BoronicAcids Boronate Ester Boronic Acid Potassium Trifluoroborate