1-Bromo-3-cyclopropylbenzene
- CAS No.
- 1798-85-2
- Chemical Name:
- 1-Bromo-3-cyclopropylbenzene
- Synonyms
- 3-Cyclopropylbromobenzene;(3-Bromophenyl)cyclopropane;3-Cyclopropylbromobenzene 97%;1-BROMO-3-CYCLOPROPYL BENZENE;Benzene, 1-broMo-3-cyclopropyl-;1-Bromo-3-cyclopropylbenzene97%;1-Bromo-3-cyclopropylbenzene 97%
- CBNumber:
- CB5369760
- Molecular Formula:
- C9H9Br
- Molecular Weight:
- 197.07
- MDL Number:
- MFCD01070823
- MOL File:
- 1798-85-2.mol
- MSDS File:
- SDS
| storage temp. | Sealed in dry,Room Temperature |
|---|---|
| form | liquid |
| color | Clear, colourless |
| Sensitive | Light Sensitive |
| InChI | 1S/C9H9Br/c10-9-3-1-2-8(6-9)7-4-5-7/h1-3,6-7H,4-5H2 |
| InChIKey | BCBNVQYWODLZSI-UHFFFAOYSA-N |
| SMILES | Brc1cc(ccc1)C2CC2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| HS Code | 2903998090 |
| Storage Class | 11 - Combustible Solids |
1-Bromo-3-cyclopropylbenzene price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000086 | 1-Bromo-3-cyclopropylbenzene Aldrich | 1798-85-2 | 1g | $191 | 2026-04-30 | Buy |
| Activate Scientific | AS39670 | 1-Bromo-3-cyclopropylbenzene 95% | 1798-85-2 | 1g | $115 | 2026-06-04 | Buy |
| Activate Scientific | AS39670 | 1-Bromo-3-cyclopropylbenzene 95% | 1798-85-2 | 5g | $341 | 2026-06-04 | Buy |
| Activate Scientific | AS39670 | 1-Bromo-3-cyclopropylbenzene 95% | 1798-85-2 | 25g | $832 | 2026-06-04 | Buy |
| Apolloscientific | OR2979 | 1-Bromo-3-cyclopropylbenzene 97% | 1798-85-2 | 1g | $111 | 2026-06-04 | Buy |
1-Bromo-3-cyclopropylbenzene Chemical Properties, Uses, Production
Synthesis
75-11-6
2039-86-3
1798-85-2
A 1.0 M hexane solution of diethylzinc (27.3 mL, 27.3 mmol) was slowly added dropwise to a solution of dichloromethane (100 mL) containing 2,4,6-trichlorophenol (5.4 g, 27.3 mmol) at -40 °C. After stirring the reaction mixture for 15 minutes, diiodomethane (2.2 mL, 27.3 mmol) was added at the same temperature and stirring was continued for 15 minutes. Subsequently, 1-bromo-3-vinylbenzene (2.5 g, 13.7 mmol) was added to the reaction system, slowly warmed to room temperature and stirred overnight. After completion of the reaction, the reaction mixture was diluted with dichloromethane and washed sequentially with 1N HCl (twice), saturated sodium bicarbonate solution (twice), saturated sodium sulfite solution, 1N sodium hydroxide solution and saturated brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated.GC-MS analysis showed that the reaction mixture contained 1-bromo-3-cyclopropylbenzene and unreacted 1-bromo-3-vinylbenzene. To remove 1-bromo-3-vinylbenzene, the crude product was reacted with potassium permanganate solution. This was done by adding an aqueous solution of potassium permanganate (1.5 g of potassium permanganate dissolved in 20 mL of water) drop by drop to a solution of tetrahydrofuran (40 mL) of the crude product (about 5 g) at 0 °C, followed by a slow warming to room temperature. After 1 h, the reaction mixture was diluted with ether, washed sequentially with water and saturated brine, and the organic phase was dried over anhydrous sodium sulfate, filtered and concentrated. Purification by fast column chromatography using 100% hexane as eluent gave 1-bromo-3-cyclopropylbenzene (2.20 g, 81% yield). Next, a hexane solution of 1.6 M n-butyllithium (3.2 mL, 5.1 mmol) was added dropwise to a solution of 1-bromo-3-cyclopropylbenzene at -78 °C and stirred for 1 hour. Subsequently, the reaction mixture was transferred via cannula to a 250 mL round bottom flask pre-filled with dry ice and stirred for 1 hour. The reaction mixture was concentrated and the residue was diluted with water. The aqueous layer was washed with dichloromethane (3 times) and subsequently acidified to pH 2 with 1N HCl and extracted with ethyl acetate. The organic phase was washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 3-cyclopropylbenzoic acid (356 mg, 43% yield, white solid).1H NMR (DMSO-d6, ppm): δ 12.90 (bs, 1H), 7.71 (d, 1H), 7.64 (s, 1H), 7.34 (m, 2H), 2.01 ( m, 1H), 0.99 (m, 2H), 0.70 (m, 2H).
References
[1] Patent: WO2004/14881, 2004, A2. Location in patent: Page 136-137
[2] Patent: WO2005/121106, 2005, A1. Location in patent: Page/Page column 54
1-Bromo-3-cyclopropylbenzene Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Fei Yan Chemical Technology Co., Ltd. | 021-34663897 13816465839 | 1141976404@qq.com | China | 41 | 57 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4554 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | 94644163@qq.com | China | 1934 | 56 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
View Latest Price from 1-Bromo-3-cyclopropylbenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 1-Bromo-3-cyclopropylbenzene
1798-85-2
|
$1.00-101.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2020-01-09 | 1-Bromo-3-cyclopropylbenzene
1798-85-2
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 1-Bromo-3-cyclopropylbenzene
1798-85-2
- $1.00-101.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1-Bromo-3-cyclopropylbenzene
1798-85-2
- $1.00
- 99%
- Career Henan Chemical Co
