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S- (+)-Rolipram

S- (+)-Rolipram Structure
S- (+)-Rolipram structure
CAS No.
85416-73-5
Chemical Name:
S- (+)-Rolipram
Synonyms
(+)-Rolipram;(S)-(+)-ROLIPRAM;Rolipram (S)-(+)-;S- (+)-Rolipram (ME-3167;(+)-ROLIPRAM;(S)-ROLIPRAM;S- (+)-Rolipram USP/EP/BP;(S)-(+)-Rolipram, 10 mM in DMSO;(S)-(+)-Rolipram, PDE4 inhibitor;Risperidone Impurity 4-d4（Risperidone EP Impurity D-d4）;(4S)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone
CBNumber:
CB5397417
Molecular Formula:
C16H21NO3
Molecular Weight:
275.34
MDL Number:
MFCD03093861
MOL File:
85416-73-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-17 09:03:53
Product description Number Pack Size Price
(S)-(+)-Rolipram >98.0%(HPLC) R0183 10mg $135
(S)-(+)-Rolipram >98.0%(HPLC) R0183 50mg $473
S-(+)-Rolipram Asreported 256569 10mg $480
S-(+)-Rolipram Asreported 256569 50mg $1338
(S)-(+)-Rolipram 99.96% CS-2478 5mg $60
More product size
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S- (+)-Rolipram Properties

Melting point 133-136℃
Density 1.155
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
form White to off-white solid.
color White to Almost white
FDA UNII H6G4VMQ24K

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933.79.1500

S- (+)-Rolipram price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical R0183 (S)-(+)-Rolipram >98.0%(HPLC) 85416-73-5 10mg $135 2026-04-30 Buy
TCI Chemical R0183 (S)-(+)-Rolipram >98.0%(HPLC) 85416-73-5 50mg $473 2026-04-30 Buy
Usbiological 256569 S-(+)-Rolipram Asreported 85416-73-5 10mg $480 2026-06-03 Buy
Usbiological 256569 S-(+)-Rolipram Asreported 85416-73-5 50mg $1338 2026-06-03 Buy
ChemScene CS-2478 (S)-(+)-Rolipram 99.96% 85416-73-5 5mg $60 2026-06-04 Buy
Product number Packaging Price Buy
R0183 10mg $135 Buy
R0183 50mg $473 Buy
256569 10mg $480 Buy
256569 50mg $1338 Buy
CS-2478 5mg $60 Buy

S- (+)-Rolipram Chemical Properties,Uses,Production

Uses

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer

Uses

S-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase. It is the S isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor

Definition

ChEBI: The (S)-enantiomer of rolipram.

Biological Activity

Less active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ).

in vivo

(+)-Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats[2].
(+)-Rolipram (0.06-25 mg/kg; a single i.p.) causes a dose-related fall in rectal temperature of rats[2].

IC 50

PDE4: 1100 nM (IC50)

storage

Room temperature

S- (+)-Rolipram synthesis

959799-63-4
85416-73-5
Synthesis of S- (+)-Rolipram from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

S- (+)-Rolipram Preparation Products And Raw materials

Raw materials

3-CYCLOPENTYLOXY-4-METHOXYBENZALDEHYDE Bromocyclopentane Isovanillin

Preparation Products

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

S- (+)-Rolipram Suppliers

Global( 104)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569262 +86-15003564040 1056@dideu.com China 3968 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21135 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
Alfa Chemistry 		+1-5166625404; Info@alfa-chemistry.com United States 20000 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Supplier Advantage
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Alfa Chemistry 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Henan Fengda Chemical Co., Ltd 		58

View Lastest Price from S- (+)-Rolipram manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(+)-Rolipram pictures 2026-07-17 (S)-(+)-Rolipram
85416-73-5
 $44.00-137.00 99.71% 10g TargetMol Chemicals Inc.
S- (+)-Rolipram pictures 2026-02-02 S- (+)-Rolipram
85416-73-5
 5mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
S- (+)-Rolipram pictures 2020-03-16 S- (+)-Rolipram
85416-73-5
 $1.00 1KG 97%-99.9% 100KG Career Henan Chemical Co

S- (+)-Rolipram Spectrum

S- (+)-Rolipram(85416-73-5)1HNMR

85416-73-5(S- (+)-Rolipram)Related Search:

ZARDAVERINE RO 20-1724 Roflumilast ETAZOLATE BRL 50481
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AG 1295 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE EHNA HYDROCHLORIDE (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE S- (+)-Rolipram
4-(3'-Methoxyphenyl)-2-pyrrolidinone 4-(4'-Methoxyphenyl)-2-pyrrolidinone 1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

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(S)-(+)-ROLIPRAM (4S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one Rolipram (S)-(+)- (4S)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE (+)-ROLIPRAM;(S)-ROLIPRAM (4S)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone (S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (4S)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)- (S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one S- (+)-Rolipram USP/EP/BP S- (+)-Rolipram (ME-3167 (+)-Rolipram TNFα,tumor,inhibit,(S)(+)Rolipram,mononuclear,Apoptosis,phosphodiesterase,(S) (+) Rolipram,Phosphodiesterase (PDE),cAMP,Inhibitor,factor,necrosis Risperidone Impurity 4-d4（Risperidone EP Impurity D-d4） (S)-(+)-Rolipram, PDE4 inhibitor (S)-(+)-Rolipram, 10 mM in DMSO 85416-73-5 Signalling Cyclic Nucleotide related Inhibitors