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Trichlormethiazide

Trichlormethiazide Structure
Trichlormethiazide structure
CAS No.
133-67-5
Chemical Name:
Trichlormethiazide
Synonyms
TRICLORMETIAZIDA;TRICHLOROMETHIAZIDE;Naqua;Flurese;Naquival;Metahydrin;Navis;Nydor;Nakva;Natril
CBNumber:
CB5407444
Molecular Formula:
C8H8Cl3N3O4S2
Molecular Weight:
380.66
MDL Number:
MFCD00057315
MOL File:
133-67-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Trichlormethiazide Properties

Melting point 248-250℃
Boiling point 631.3±65.0 °C(Predicted)
Density 1.748
refractive index 1.6000 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka pKa 6.9(acetone/H2O) (Uncertain)
color White to Off-White
Merck 14,9624
Major Application pharmaceutical (small molecule)
InChI 1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChIKey LMJSLTNSBFUCMU-UHFFFAOYSA-N
SMILES NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl
CAS DataBase Reference 133-67-5(CAS DataBase Reference)
FDA UNII Q58C92TUN0
ATC code C03AA06
EPA Substance Registry System Trichlormethiazide (133-67-5)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P304+P340+P312
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  36
RIDADR  UN2811
WGK Germany  2
RTECS  DK8925000
TSCA  TSCA listed
HazardClass  6.1
HS Code  2935904000
Storage Class 11 - Combustible Solids
Hazard Classifications Resp. Sens. 1
Skin Sens. 1
Hazardous Substances Data 133-67-5(Hazardous Substances Data)
Toxicity LD50 orally in rats: >20000 mg/kg (Goldenthal)
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
0
1 0

Trichlormethiazide price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1681000 Trichlormethiazide United States Pharmacopeia (USP) Reference Standard 133-67-5 200mg $400 2026-04-30 Buy
TCI Chemical T1318 Trichloromethiazide >99.0%(T) 133-67-5 10g $149 2026-04-30 Buy
Cayman Chemical 29331 Trichlormethiazide ≥98% 133-67-5 1g $36 2026-04-30 Buy
Cayman Chemical 29331 Trichlormethiazide ≥98% 133-67-5 5g $120 2026-04-30 Buy
Cayman Chemical 29331 Trichlormethiazide ≥98% 133-67-5 10g $186 2026-04-30 Buy
Product number Packaging Price Buy
1681000 200mg $400 Buy
T1318 10g $149 Buy
29331 1g $36 Buy
29331 5g $120 Buy
29331 10g $186 Buy

Trichlormethiazide Chemical Properties, Uses, Production

Chemical Properties

Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.

Originator

Naqua,Schering,US,1960

Uses

diuretic, antihypertensive

Uses

Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.

Uses

Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).

Definition

ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.

Manufacturing Process

A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.

Therapeutic Function

Diuretic

Trichlormethiazide Preparation Products And Raw materials

Raw materials

5-Chloro-2-methyl-4-isothiazolin-3-one Dichloroacetaldehyde 4-Amino-6-chlorobenzene-1,3-disulfonamide

Preparation Products

Trichlormethiazide Suppliers

Global Suppliers ( 188)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Aemon Chemical 0086-755-86198205 acinfo@aemonchem.com China 1928 57
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Adamas Reagent, Ltd. 59
LGM Pharma 70
Sichuan Kulinan Technology Co., Ltd 57
Sinopharm Chemical Reagent Co,Ltd. 79
Aemon Chemical 57
Maya High Purity Chemicals 57

View Latest Price from Trichlormethiazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trichlormethiazide pictures 2026-07-27 Trichlormethiazide
133-67-5
 $33.00 99.54% 10g TargetMol Chemicals Inc.
Trichlormethiazide pictures 2026-07-27 Trichlormethiazide
133-67-5
 $33.00 99.54% 10g TargetMol Chemicals Inc.
Trichlormethiazide pictures 2026-01-14 Trichlormethiazide
133-67-5
 25kg 98.0% 2000kg Taixing Foreign Trade Nanjing Co., Ltd.

Trichlormethiazide Spectrum

Trichlormethiazide(133-67-5)MSTrichlormethiazide(133-67-5)1HNMRTrichlormethiazide(133-67-5)13CNMRTrichlormethiazide(133-67-5)IR1Trichlormethiazide(133-67-5)IR2

133-67-5 (Trichlormethiazide) Related Search:

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6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide 6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide 6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio Achletin Anistadin Aponorin Carvacron Chlopolidine Ciba 7057-Su ciba7057-su component of Metatensin component of Naquival Cretonin Diu-Hydrin Diurazida Diurese Diuroral Trichlormethiazid Trichloromethiadiazide Triclordiuride Triclormetiazide Triflumen 3-Dichlormethylhydrochlorothiazide TRICHLORMETHIAZIDE,USP 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide (6CI, 8CI, 9CI) 6-Chloro-3-dichloromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide NSC 61560 Salirom 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (-)- (9CI) Natril Navis Nydor Pluvex 6-chloro-3-(dichloromethyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide Trichlormethiazide (200 mg) TRICLORMETIAZIDA trichlormethtazide TRICHLORMETHIAZIDE TRICHLOROMETHIAZIDE 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydr 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide 3-dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide 3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-d 3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio 3-dichloromethylhydrochlorothiazide 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonam e1,1-dioxide Esmarin Eurinol Fluitran Flurese