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Methyl pyrrolidine-2-carboxylate hydrochloride

Methyl pyrrolidine-2-carboxylate hydrochloride structure

CAS No.: 65365-28-8

Chemical Name:: Methyl pyrrolidine-2-carboxylate hydrochloride

Synonyms: METHYL D-PROLINATE HYDROCHLORIDE;D-PRO-OME;D-Pro-Ome.Hcl;D-PROLINE METHYL ESTER HYDROCHLORIDE;H-D-Pro-OMe;96.0%(N&H-D-PRO-OME HCL;D-PROLINE-OME HCL;Methyl pyrrolidine-2;H-D-Pro-OMe·HCl (Solid)

CBNumber:: CB5675050

Molecular Formula:: C6H12ClNO2

Molecular Weight:: 165.62

MDL Number:: MFCD00083685

MOL File:: 65365-28-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:23:08

Product description	Number	Pack Size	Price
D-Proline methyl ester hydrochloride ≥98.0% (AT)	689491	5g	$132
D-Proline methyl ester hydrochloride ≥98.0% (AT)	689491	1g	$30
D-Proline Methyl Ester Hydrochloride >96.0%(N)(T)	P1730	1g	$29
D-Proline Methyl Ester Hydrochloride >96.0%(N)(T)	P1730	5g	$81
D-Proline methyl ester hydrochloride Asreported	287516	5g	$432
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Methyl pyrrolidine-2-carboxylate hydrochloride Properties

Melting point	69-71°C
refractive index	32 ° (C=1, H2O)
storage temp.	2-8°C
solubility	Methanol (Slightly), Water (Slightly, Sonicated)
form	Powder or Crystalline Powder
color	White
optical activity	[α]/D 33.0±2.0°, c = 1 in H2O
Sensitive	Hygroscopic
BRN	4714125
Major Application	peptide synthesis
InChI	1S/C6H11NO2.ClH/c1-9-6(8)5-3-2-4-7-5;/h5,7H,2-4H2,1H3;1H/t5-;/m1./s1
InChIKey	HQEIPVHJHZTMDP-NUBCRITNSA-N
SMILES	Cl.COC(=O)[C@H]1CCCN1
CAS DataBase Reference	65365-28-8(CAS DataBase Reference)
FDA UNII	C15EPU1M46
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/38-36/37/38

Safety Statements

26-36-28

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		1

Methyl pyrrolidine-2-carboxylate hydrochloride price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	689491	D-Proline methyl ester hydrochloride ≥98.0% (AT)	65365-28-8	5g	$132	2026-04-30	Buy
Sigma-Aldrich	689491	D-Proline methyl ester hydrochloride ≥98.0% (AT)	65365-28-8	1g	$30	2023-06-20	Buy
TCI Chemical	P1730	D-Proline Methyl Ester Hydrochloride >96.0%(N)(T)	65365-28-8	1g	$29	2026-04-30	Buy
TCI Chemical	P1730	D-Proline Methyl Ester Hydrochloride >96.0%(N)(T)	65365-28-8	5g	$81	2026-04-30	Buy
Usbiological	287516	D-Proline methyl ester hydrochloride Asreported	65365-28-8	5g	$432	2026-06-03	Buy

Product number	Packaging	Price	Buy
689491	5g	$132	Buy
689491	1g	$30	Buy
P1730	1g	$29	Buy
P1730	5g	$81	Buy
287516	5g	$432	Buy

Methyl pyrrolidine-2-carboxylate hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Crystalline

Uses

D-Proline Methyl Ester is a methyl ester of D-Proline (P755990) which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

609-36-9

2133-40-6

The general steps for the synthesis of L-proline methyl ester hydrochloride from methanol and DL-proline are as follows: Step 1: Synthesis of methylpyrrolidine-2-carboxylic acid hydrochloride Thionyl chloride (15.7 mL, 217.4 mmol) was slowly added dropwise to a mixed solution of DL-proline (5.0 g, 43.47 mmol) and methanol (50 mL) at about 0 °C, and the dropwise process lasted for about 15 minutes. The reaction mixture was stirred at room temperature for about 16 hours before the solvent was removed by vacuum concentration. The resulting gel was ground with n-pentane, decanted and dried to give D-proline methyl ester hydrochloride as an off-white solid (6.25 g, 87% yield). The product characterization data were as follows: 1H NMR (400 MHz, DMSO-d6) δ 1.87-2.04 (m, 3H), 2.21-2.28 (m, 1H), 3.22-3.26 (m, 2H), 3.75 (s, 3H), 4.34 (t, J = 7.8 Hz, 1H). IR (film) υ 3513, 3130, 2597, 1740, 1632, 1452, 1402, 1245, 1178, 1046, 764 cm-1; MS 130 (M + 1).

References

[1] Bulletin de la Societe Chimique de France, 1993, vol. 130, p. 584 - 596
[2] Patent: US2010/105755, 2010, A1. Location in patent: Page/Page column 11-12
[3] Molecules, 2008, vol. 13, # 5, p. 1111 - 1119
[4] Journal of Organic Chemistry, 1991, vol. 56, # 8, p. 2775 - 2781
[5] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 91; 93

Methyl pyrrolidine-2-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Methanol PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER DL-Proline L-Proline

Preparation Products

Methyl pyrrolidine-2-carboxylate hydrochloride Suppliers

Global( 245)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-15680023009	ni@enlaibio.com	China	1103	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	937	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
GenicBio Limited	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Sichuan Jiaying Lai Technology Co.,LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Jinan Liheng Biotechnology Co., Ltd.	58

View Lastest Price from Methyl pyrrolidine-2-carboxylate hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-14	D-Pro-ome.HCl 65365-28-8		1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2020-01-06	D-Pro-ome.HCl 65365-28-8	$1.00	1g	98%	100KG	Sichuan Jiaying Lai Technology Co.,LTD
2019-09-02	Methyl pyrrolidine-2-carboxylate hydrochloride 65365-28-8	$7.00	1KG	99%		Career Henan Chemical Co

D-Pro-ome.HCl
65365-28-8
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

D-Pro-ome.HCl
65365-28-8
$1.00
98%
Sichuan Jiaying Lai Technology Co.,LTD

Methyl pyrrolidine-2-carboxylate hydrochloride
65365-28-8
$7.00
99%
Career Henan Chemical Co

Methyl pyrrolidine-2-carboxylate hydrochloride Spectrum

Methyl pyrrolidine-2-carboxylate hydrochloride(65365-28-8)¹HNMR

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H-D-PRO-OME HCL D-PROLINE METHYL ESTER HCL D-PROLINE METHYL ESTER HYDROCHLORIDE SALT D-PROLINE-OME HCL D-PYRROLIDINE-2-CARBOXYLIC ACID-METHYL ESTER HCL D-proline methy ester hydrochloride Methyl pyrrolidine-2-carboxylate hydrochloride Pyrrolidine-2-carboxylic acid methyl ester hydrochloride Methyl pyrrolidine-2 H-D-Pro-OMe Methyl (2R)-pyrrolidine-2-carboxylate hydrochloride H-D-Pro-OMe·HCl D-Proline Methyl ester hydrochloride D-Methyl pyrrolidine-2-carboxylate hydrochloride Methyl (2R)-pyrrolidine-2-carboxylate Monohydrochloride (R)-Methyl pyrrolidine-2-carboxylate hydrochloride D-Proline, Methylester, hydrochloride (1:1) D-Proline Methyl Ester Hydrochloride , 96.0%(N&T (R)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride D-Proline methyl ester hydrochloride≥99% (HPLC) Methyl D-Prolinate Hydrochloride,99%e.e. D-Proline methyleester hydrochloride H-D-Pro-OMe·HCl (Solid) D-Proline methyl ester hydrochloride >=98.0% (AT) Methyl (2R)-pyrrolidine-2-carboxylate hydrochloride 97% D-ProlineMethylEsterHydrochloride> 96.0%(N& Methyl pyrrolidine-2-carboxylate hydrochloride USP/EP/BP methyl (2R)-pyrrolidine-2-carboxylate D-Proline methyl ester hydrochloride D-PROLINE METHYL ESTER HYDROCHLORIDE D-Pro-Ome.Hcl D-PRO-OME METHYL D-PROLINATE HYDROCHLORIDE 65365-28-8 6335-28-8 63365-28-8 5365-28-8 C6H11NO2HCl C6H12NO2Cl Amino Acids and Derivatives Amino Acid Methyl Esters Amino Acids (C-Protected) Biochemistry Amino hydrochloride Amino Acid Derivatives Peptide Synthesis Proline Amino Acids