DL-Proline
- CAS No.
- 609-36-9
- Chemical Name:
- DL-Proline
- Synonyms
- PYRROLIDINE-2-CARBOXYLIC ACID;H-DL-PRO-OH;DL-Prolin;DL-Pro;DL-Pro-OH;DL-PROLINE;Proline, DL-;(RS)-Proline;DL-Proline>DL-Proline,99%
- CBNumber:
- CB4149769
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD00005250
- MOL File:
- 609-36-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 208 °C (dec.) (lit.) |
|---|---|
| Boiling point | 215.41°C (rough estimate) |
| Density | 1.1808 (rough estimate) |
| refractive index | 1.4538 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Methanol, Water |
| pka | 2.35±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to off-white |
| Water Solubility | SOLUBLE |
| Merck | 14,7780 |
| BRN | 80809 |
| Major Application | peptide synthesis |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING HAIR CONDITIONING |
| InChI | 1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8) |
| InChIKey | ONIBWKKTOPOVIA-UHFFFAOYSA-N |
| SMILES | OC(=O)C1CCCN1 |
| CAS DataBase Reference | 609-36-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | DCS9E77JPQ |
| NIST Chemistry Reference | DL-Proline(609-36-9) |
| EPA Substance Registry System | Proline (609-36-9) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P304+P340-P305+P351+P338-P312-P321 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
DL-Proline price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 171824 | DL-Proline ReagentPlus , 99% | 609-36-9 | 1g | $38.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 171824 | DL-Proline ReagentPlus , 99% | 609-36-9 | 5g | $49.2 | 2026-04-30 | Buy |
| TCI Chemical | P0480 | DL-Proline >99.0%(T) | 609-36-9 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | P0480 | DL-Proline >99.0%(T) | 609-36-9 | 5g | $41 | 2026-04-30 | Buy |
| Usbiological | 286585 | DL-Proline Asreported | 609-36-9 | 50g | $418 | 2026-06-03 | Buy |
DL-Proline Chemical Properties,Uses,Production
Chemical Properties
white to off-white crystalline powder
Uses
DL-Proline is the racemic mixture of both L-Proline (P755995) and D-Proline (P755990).
Definition
ChEBI: An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
Input 100g of glacial acetic acid into the reaction kettle, and then input 100g of L-proline under stirring to obtain the reaction solution. After the reaction solution was stirred and warmed to 70-75C, it was kept warm and stirred for 3h to make the L-proline fully racemic, which in turn made the reaction solution have a spin of 0, and at this time, the reaction solution was reddish-brown in color.
The reaction solution with spin 0 was cooled to 30 , and then moved to the distillation kettle for distillation under reduced pressure, the temperature of distillation was at 55-60 , the vapor pressure was 0.1MPa, and the distillation was continued for 30min after distillation until there was no liquid effluent, and then the residue of distillation was concentrated to 10% of the original volume to obtain the viscous concentrate A.
The concentrate A was mixed with 120g of isopropanol, stirred until the crystals precipitated completely, then cooled down to 15C, centrifuged to remove excess liquid, and the crystals were rinsed with isopropanol to obtain the crude product.
Mix 90g of crude product, 5g of activated carbon, 185g of water and stir to raise the temperature to 70, keep warm and stir for 30min to make the crude product dissolve completely, then filter to remove the activated carbon. The residue without activated carbon after filtration was concentrated to 20% of the original volume to obtain a viscous concentrate B.
The concentrate B was mixed with 285g of isopropanol, stirred until the crystals precipitated completely, then cooled to 15C, centrifuged to remove the excess liquid, rinsed the crystals with isopropanol, and after rinsing, the crystals were dried at 80C for 12h to obtain the sample of DL-proline.
DL-Proline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huaibei Desung Biotech Co., Ltd. | 0561-2337889 13515618601 | 390478052@qq.com | China | 1967 | 58 |
| Yuanyan Chemical (Shandong) Co., Ltd | 17806130302 | 420700630@qq.com | China | 317 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
View Lastest Price from DL-Proline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | DL-Pro-OH
609-36-9
|
1kg | 99% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-09-11 | DL-Proline
609-36-9
|
1KG | 98.0%-101.0% | 10 TONS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-03-20 | DL-Proline
609-36-9
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- DL-Pro-OH
609-36-9
- 99%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- DL-Proline
609-36-9
- 98.0%-101.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- DL-Proline
609-36-9
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
