Tipelukast
- CAS No.
- 125961-82-2
- Chemical Name:
- Tipelukast
- Synonyms
- KCA 757;tipelukast;MN-001 (Tipelukast);MN 001 (pharMaceutical);Butanoic acid, 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)thio]propoxy]-2-propylphenoxy]-;4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)sulfanyl]propoxy]-2-propylphenoxy]butanoic acid
- CBNumber:
- CB5855229
- Molecular Formula:
- C29H38O7S
- Molecular Weight:
- 530.67282
- MDL Number:
- MFCD00886138
- MOL File:
- 125961-82-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 82-84°C |
|---|---|
| Boiling point | 735.3±60.0 °C(Predicted) |
| Density | 1.22 |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | 4.59±0.10(Predicted) |
| form | Solid |
| color | Off-White to Pale Beige |
| FDA UNII | 08379P260O |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
Tipelukast price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11948 | MN-001 ≥98% | 125961-82-2 | 500μg | $79 | 2026-04-30 | Buy |
| Cayman Chemical | 11948 | MN-001 ≥98% | 125961-82-2 | 1mg | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 11948 | MN-001 ≥98% | 125961-82-2 | 5mg | $504 | 2026-04-30 | Buy |
| TRC | TRC-T444870-2.5MG | Tipelukast | 125961-82-2 | 2.5mg | $262 | 2026-06-03 | Buy |
| TRC | TRC-T444870-1MG | Tipelukast | 125961-82-2 | 1mg | $135 | 2026-06-03 | Buy |
Tipelukast Chemical Properties, Uses, Production
Uses
Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.
Definition
ChEBI: Tipelukast is an aromatic ketone.
Biological Activity
Tipelukast is a Leukotriene D4 (LTD4) receptor antagonist and an inhibitor of 5-lipoxygenase (5-LO) and also phosphodiesterases PDE3 and PDE4. It has been found to have antifibrotic and anti-inflammatory activity. Tipelukast has been investigated as a possible treatment for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
in vivo
Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction[1]. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs[2].
IC 50
LTD4: 6.41 (pA2, In guinea-pigs); LTE4: 6.45 (pA2, In guinea-pigs)
Tipelukast Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
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