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2'-Hydroxy-4',5'-dimethoxyacetophenone

2'-Hydroxy-4',5'-dimethoxyacetophenone structure

CAS No.: 20628-06-2

Chemical Name:: 2'-Hydroxy-4',5'-dimethoxyacetophenone

Synonyms: 1-(2-HYDROXY-4,5-DIMETHOXYPHENYL)ETHAN-1-ONE;AURORA KA-3659;4,5-DIMETHOXY-2-HYDROXYACETOPHENONE;2'-Hydroxy-4',5'-dimethoxyacetophenone;4',5'-DIMETHOXY-2'-HYDROXYACETOPHENONE;4',5'-Dimethoxyt-2'-hydroxyacetophenone;2'-Hydroxy-4',5'-dimethoxyacetophenone>4',5'- Dimethoxyt -2'- hydroxy acetophenone;Ethanone, 1-(2-hydroxy-4,5-dimethoxyphenyl)-

CBNumber:: CB6153764

Molecular Formula:: C10H12O4

Molecular Weight:: 196.2

MDL Number:: MFCD00017241

MOL File:: 20628-06-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:56

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2'-Hydroxy-4',5'-dimethoxyacetophenone Properties

Melting point	113-114°C
Boiling point	332.3±37.0 °C(Predicted)
Density	1.172±0.06 g/cm3(Predicted)
storage temp.	RT, stored under nitrogen
pka	10.29±0.23(Predicted)
form	powder
color	White to Light yellow to Light orange
InChI	1S/C10H12O4/c1-6(11)7-4-9(13-2)10(14-3)5-8(7)12/h4-5,12H,1-3H3
InChIKey	KEQHBVWVKYHDCS-UHFFFAOYSA-N
SMILES	COc1cc(O)c(cc1OC)C(C)=O
CAS DataBase Reference	20628-06-2(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

2914500090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

2'-Hydroxy-4',5'-dimethoxyacetophenone price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H9904	2′-Hydroxy-4′,5′-dimethoxyacetophenone	20628-06-2	5g	$330	2023-06-20	Buy
TCI Chemical	H1206	2'-Hydroxy-4',5'-dimethoxyacetophenone >98.0%(GC)	20628-06-2	5g	$130	2026-04-30	Buy
Biosynth	FD71265	4,5-Dimethoxy-2-hydroxyacetophenone	20628-06-2	10g	$181.5	2026-06-04	Buy
Biosynth	FD71265	4,5-Dimethoxy-2-hydroxyacetophenone	20628-06-2	25g	$362.75	2026-06-04	Buy
Biosynth	FD71265	4,5-Dimethoxy-2-hydroxyacetophenone	20628-06-2	50g	$1089	2026-06-04	Buy

Product number	Packaging	Price	Buy
H9904	5g	$330	Buy
H1206	5g	$130	Buy
FD71265	10g	$181.5	Buy
FD71265	25g	$362.75	Buy
FD71265	50g	$1089	Buy

2'-Hydroxy-4',5'-dimethoxyacetophenone Chemical Properties,Uses,Production

Uses

1-(2-Hydroxy-4,5-dimethoxyphenyl)ethanone is a useful reagent in Vilsmeier-Haack reaction.

Preparation

Preparation by partial methylation of 2,5-dihydroxy-4-methoxyacetophenone, with methyl iodide in the presence of potassium carbonate in refluxing acetone (81%) ; with dimethyl sulfate in the presence of potassium carbonate in refluxing acetone (71%), in the presence of sodium methoxide in methanol (byproduct) or in the presence of sodium hydroxide in boiling aqueous ethanol (37%) ; with an excess of ethereal diazomethane in methanol (93%).

2'-Hydroxy-4',5'-dimethoxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

2'-Hydroxy-4',5'-dimethoxyacetophenone Suppliers

Global( 94)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80
TCI Europe	320-37350700	sales@tcieurope.eu	Europe	23654	75
TCI AMERICA	800-4238616	sales@tciamerica.com	Americas	23636	75
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	22497	55
Shanghai Hao Yun Chemical Science Co.,Ltd.	021-68367562	sales@haoyunchem.com	China	493	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
TOKYO CHEMICAL INDUSTRY CO., LTD.	80
TCI Europe	75
TCI AMERICA	75
9ding chemical ( Shanghai) Limited	55
Shanghai Hao Yun Chemical Science Co.,Ltd.	55
Bide Pharmatech Ltd.	60

2'-Hydroxy-4',5'-dimethoxyacetophenone Spectrum

2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE(20628-06-2)MS 2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE(20628-06-2)¹HNMR 2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE(20628-06-2)¹³CNMR 2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE(20628-06-2)IR1

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AURORA KA-3659 4',5'-DIMETHOXY-2'-HYDROXYACETOPHENONE 4,5-DIMETHOXY-2-HYDROXYACETOPHENONE 2'-Hydroxy-4',5'-dimethoxyacetophenone> Ethanone, 1-(2-hydroxy-4,5-dimethoxyphenyl)- 4',5'- Dimethoxyt -2'- hydroxy acetophenone 4',5'-Dimethoxyt-2'-hydroxyacetophenone 1-(2-HYDROXY-4,5-DIMETHOXYPHENYL)ETHAN-1-ONE 2'-Hydroxy-4',5'-dimethoxyacetophenone 20628-06-2 C10 Building Blocks Organic Building Blocks Ketones Carbonyl Compounds Aromatic Acetophenones & Derivatives (substituted)